Pipemidic acid

Pipemidic acid is a member of the pyridopyrimidine class of antibacterials, which display some overlap in mechanism of action with analogous pyridone-containing quinolones. It was introduced in 1979 and is active against gram negative and some gram positive bacteria. It was used for gastrointestinal, biliary, and urinary infections.[1] The marketing authorization of pipemidic acid has been suspended throughout the EU.[2]

Pipemidic acid
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
  • 8-Ethyl-5-oxo-2-piperazin-1-yl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.052.283
Chemical and physical data
FormulaC14H17N5O3
Molar mass303.322 g·mol−1
3D model (JSmol)
  • CCN1C=C(C(=O)C2=CN=C(N=C21)N3CCNCC3)C(=O)O
  • InChI=1S/C14H17N5O3/c1-2-18-8-10(13(21)22)11(20)9-7-16-14(17-12(9)18)19-5-3-15-4-6-19/h7-8,15H,2-6H2,1H3,(H,21,22)
  • Key:JOHZPMXAZQZXHR-UHFFFAOYSA-N

References
  1. "Pipemidic Acid - MeSH - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2019-01-20.
  2. "Disabling and potentially permanent side effects lead to suspension or restrictions of quinolone and fluoroquinolone antibiotics". European Medicines Agency. 11 March 2019.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.