Progesterone synthesis inhibitor

A progesterone synthesis inhibitor, or progestogen synthesis inhibitor, is a type of drug which inhibits the enzymatic synthesis of progesterone. They include:

Inhibitors of cholesterol synthesis can also reduce progesterone production by inhibiting cholesterol production.

Progesterone synthesis inhibitors have been researched for medical applications including use as contraceptives, abortifacients, and oxytocics, though ultimately they have never been marketed for such indications.[1] Examples of such agents include the 3β-HSD inhibitors azastene (WIN-17625) and epostane (WIN-32729). Since progesterone is a precursor of many other steroid hormones, progesterone synthesis inhibitors can also be used medically as inhibitors of the synthesis of these other steroid hormones, including of androgens, estrogens, glucocorticoids, mineralocorticoids, and neurosteroids.

See also

References

  1. Ray S, Sharma I (1987). "Development of progesterone antagonists as fertility regulating agents". Pharmazie. 42 (10): 656–61. PMID 3325988.
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