Rap GTP-binding protein

Rap GTP-binding protein also known as Ras-related proteins or simply RAP is a type of small GTPase, similar in structure to Ras.

RAP1A,
member of RAS oncogene family
Identifiers
SymbolRAP1A
NCBI gene5906
HGNC9855
OMIM179520
RefSeqNM_002884
UniProtP62834
Other data
LocusChr. 1 p13.3
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StructuresSwiss-model
DomainsInterPro
RAP1B,
member of RAS oncogene family
Identifiers
SymbolRAP1B
NCBI gene5908
HGNC9857
OMIM179530
RefSeqNM_015646
UniProtP61224
Other data
LocusChr. 12 q14
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StructuresSwiss-model
DomainsInterPro

These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. RAP counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner.[1][2]

Family members

Human genes that encode Ras-related proteins include:

References
  1. "RAP1A RAP1A, member of RAS oncogene family". Entrez Gene. United States National Library of Medicine.
  2. Rousseau-Merck MF, Pizon V, Tavitian A, Berger R (1990). "Chromosome mapping of the human RAS-related RAP1A, RAP1B, and RAP2 genes to chromosomes 1p12----p13, 12q14, and 13q34, respectively". Cytogenet. Cell Genet. 53 (1): 2–4. doi:10.1159/000132883. PMID 2108841.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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