Menotropin

Menotropin (also called human menopausal gonadotropin or hMG) is a hormonally active medication for the treatment of fertility disturbances. Frequently the plural is used as the medication is a mixture of gonadotropins. Menotropins are extracted from the urine of postmenopausal women.[1]

Menotropin
Clinical data
Trade namesRepronex
MedlinePlusa601002
ATC code
Identifiers
CAS Number
ChemSpider
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UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.119.926
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Description and usage

Urine of postmenopausal women reflects the hypergonadotropic state of menopause -levels of follicle stimulating hormone (FSH) and luteinizing hormone (LH) are high - and contain a mixture of these gonadotropins.[2][3][4] Other protein substances may be present, including small amounts of human chorionic gonadotropin (hCG).[1] In 1949 Piero Donini found a relatively simple method to extract gonadotropins from urine of postmenopausal women.[4][5] Menotropins were successfully introduced into clinical use by Bruno Lunenfeld in 1961.[4] While earlier menotropin medications contained FSH and LH at a 1:1 ratio, the recognition that it is FSH that is critical for follicle stimulation has led to development of newer preparations that contain a much higher FSH/LH ratio, Fertinex being an example.[4]

Menotropin preparations are designed for use in selected women where they stimulate the ovaries to mature follicles, thus making them more fertile. They are administered by typically daily injection, intramuscularly or subcutaneously, for about ten days under close supervision to adjust dose and duration of therapy. They can also be used in hypogonadal men to stimulate sperm production.

Human urinary-derived menotropin preparations are exposed to the theoretical risk of infection from menopausal donors of urine. Nevertheless, the failure to irrefutably demonstrate infectivity following intracerebral inoculation with urine from transmissible spongiform encephalopathy (TSE)-infected hosts suggests that the risk associated with products derived from urine is merely theoretical.[6]

Recombinant gonadotropins have to a large degree replaced hMG in fertility treatments. The recombinant process allows for the production of pure FSH or LH not "contaminated" by other proteins that may be present after urinary extraction. While some head-on studies seem not to suggest that "pure FSH" gives better results than hMG,[7] others claim that recombinant FSH is more efficient and reduces costs.[8] A Cochrane Collaboration analysis did not reveal major differences in clinical outcomes when comparing urinary versus recombinant FSH.[9]

The Practice Committee of the American Society for Reproductive Medicine reported:[10] “Compared with earlier crude animal extracts, modern highly purified urinary and recombinant gonadotropin products have clearly superior quality, specific activity, and performance. There are no confirmed differences in safety, purity, or clinical efficacy among the various available urinary or recombinant gonadotropin products.”

List of hMG preparations

A number of drug companies have and had marketed hMG preparations that include:[11]

  • Gynogen HP (Sanzyme (P) Limited)
Highly purified urinary FSH and LH in 1:1 ratio
  • Humog (Bharat Serums And Vaccines Ltd)
highly purified urinary FSH and LH in 1:1 ratio
  • Humegon (Organon)
  • Menopur (Ferring Pharmaceuticals), 75 IU FSH and 75 IU LH activity
  • Merional, Meriofert (IBSA Institut)
  • Menogon
  • Metrodin (Serono)
highly purified urinary FSH
  • Repronex (Ferring Pharmaceuticals), 75 IU FSH and 75 IU LH
  • Pergonal (Serono),
Pergonal was the major hMG prior to the arrival of recombinant gonadotropins containing 75 IU FSH and 75 IU LH.
  • HMG Massone, 75 IU FSH and 75 IU LH

See also

References
  1. van de Weijer BH, Mulders JW, Bos ES, Verhaert PD, van den Hooven HW (November 2003). "Compositional analyses of a human menopausal gonadotrophin preparation extracted from urine (menotropin). Identification of some of its major impurities". Reproductive Biomedicine Online. 7 (5): 547–557. doi:10.1016/S1472-6483(10)62071-8. PMID 14680547.
  2. Menotropins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  3. TheFreeDictionary > Menotropin Citing: Dorland's Medical Dictionary for Health Consumers. 2007
  4. Lunenfeld B (2004). "Historical perspectives in gonadotrophin therapy". Human Reproduction Update. 10 (6): 453–467. doi:10.1093/humupd/dmh044. PMID 15388674.
  5. Unknown. "Serono goes recombinant". Serono Laboratories, 2011. Archived from the original on 2013-12-02. Retrieved 2013-11-24.
  6. Reichl H, Balen A, Jansen CA (October 2002). "Prion transmission in blood and urine: what are the implications for recombinant and urinary-derived gonadotrophins?". Human Reproduction. 17 (10): 2501–2508. doi:10.1093/humrep/17.10.2501. PMID 12351519.
  7. Bagratee JS, Lockwood G, López Bernal A, Barlow DH, Ledger WL (February 1998). "Comparison of highly purified FSH (metrodin-high purity) with pergonal for IVF superovulation". Journal of Assisted Reproduction and Genetics. 15 (2): 65–69. doi:10.1007/BF02766827. PMC 3455420. PMID 9513843.
  8. Daya S, Ledger W, Auray JP, Duru G, Silverberg K, Wikland M, et al. (December 2001). "Cost-effectiveness modelling of recombinant FSH versus urinary FSH in assisted reproduction techniques in the UK". Human Reproduction. 16 (12): 2563–2569. doi:10.1093/humrep/16.12.2563. PMID 11726575.
  9. van Wely M, Kwan I, Burt AL, Thomas J, Vail A, Van der Veen F, Al-Inany HG (February 2011). Van Wely M (ed.). "Recombinant versus urinary gonadotrophin for ovarian stimulation in assisted reproductive technology cycles". The Cochrane Database of Systematic Reviews. 2011 (2): CD005354. doi:10.1002/14651858.CD005354.pub2. PMC 7388278. PMID 21328276.
  10. Practice Committee of American Society for Reproductive Medicine, Birmingham, Alabama (November 2008). "Gonadotropin preparations: past, present, and future perspectives". Fertility and Sterility. 90 (5 Suppl): S13–S20. doi:10.1016/j.fertnstert.2008.08.031. PMID 19007609.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  11. Fuller MA, Sajatovic M (2003). Drug Information Handbook for Psychiatry (4 ed.). Lexi-Comp, Inc. p. 711. ISBN 978-1-59195-064-6.
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