SCG5

Neuroendocrine protein 7B2 is a protein that in humans is encoded by the SCG5 gene.[5][6][7] The protein expressed by this gene is widely distributed in neuroendocrine tissues. It functions as a chaperone protein for the proprotein convertase PC2 by blocking the aggregation of this protein, and is required for the production of an active PC2 enzyme.[8][9] It is an intrinsically disordered protein that may also function as a chaperone for other aggregating secretory proteins in addition to proPC2 (Helwig et al. 2013). 7B2 has been identified in vertebrates and in invertebrates as low as flatworms (Protein ID: AIZ72728.1) and insects.[10] It is also called Sgne1 and Secretogranin V. In C. elegans, it was originally called e7B2[11] and then renamed Seven B Two (gene name sbt-1).[12] There is a Pfam entry for this protein: Secretogranin_V (PF05281).

SCG5
Identifiers
AliasesSCG5, 7B2, P7B2, SGNE1, SgV, secretogranin V
External IDsOMIM: 173120 MGI: 98289 HomoloGene: 37722 GeneCards: SCG5
Orthologs
SpeciesHumanMouse
Entrez

6447

20394

Ensembl

ENSG00000277614
ENSG00000166922
ENSG00000281931

ENSMUSG00000023236

UniProt

P05408

P12961

RefSeq (mRNA)

NM_001144757
NM_003020
NM_001394278
NM_001394279

NM_009162

RefSeq (protein)

NP_001138229
NP_003011

NP_033188

Location (UCSC)Chr 15: 32.64 – 32.7 MbChr 2: 113.78 – 113.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

  1. ENSG00000166922, ENSG00000281931 GRCh38: Ensembl release 89: ENSG00000277614, ENSG00000166922, ENSG00000281931 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000023236 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lloyd RV, Jin L (March 1994). "Analysis of chromogranin/secretogranin messenger RNAs in human pituitary adenomas". Diagnostic Molecular Pathology. 3 (1): 38–45. doi:10.1097/00019606-199403010-00007. PMID 8162254.
  6. Taupenot L, Harper KL, O'Connor DT (March 2003). "The chromogranin-secretogranin family". The New England Journal of Medicine. 348 (12): 1134–49. doi:10.1056/NEJMra021405. PMID 12646671.
  7. Martens GJ (July 1988). "Cloning and sequence analysis of human pituitary cDNA encoding the novel polypeptide 7B2". FEBS Letters. 234 (1): 160–4. doi:10.1016/0014-5793(88)81324-3. PMID 3134253.
  8. "Entrez Gene: SCG5 secretogranin V (7B2 protein)".
  9. Mbikay M, Seidah NG, Chrétien M (July 2001). "Neuroendocrine secretory protein 7B2: structure, expression and functions". The Biochemical Journal. 357 (Pt 2): 329–42. doi:10.1042/0264-6021:3570329. PMC 1221959. PMID 11439082.
  10. Hwang JR, Siekhaus DE, Fuller RS, Taghert PH, Lindberg I (June 2000). "Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2. Insect cell-specific processing and secretion". The Journal of Biological Chemistry. 275 (23): 17886–93. doi:10.1074/jbc.M000032200. PMID 10749852.
  11. Lindberg I, Tu B, Muller L, Dicksinson I (August 1998). "Cloning and functional analysis of C. elegans 7B2". DNA Cell Biology. 17 (8): 727. doi:10.1089/dna.1998.17.727. PMID 9726255.
  12. Sieburth, et al. (July 2005). "Systematic analysis of genes required for synapse structure and function". Nature. 436 (7050): 510. doi:10.1038/nature03809. PMID 16049479.

Further reading


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