Peptide transporter 1

Peptide transporter 1 (PepT 1) also known as solute carrier family 15 member 1 (SLC15A1) is a protein that in humans is encoded by SLC15A1 gene.[5][6] PepT 1 is a solute carrier for oligopeptides. It functions in renal oligopeptide reabsorption and in the intestines in a proton dependent way, hence acting like a cotransporter.[7]

SLC15A1
Identifiers
AliasesSLC15A1, HPECT1, HPEPT1, PEPT1, Peptide transporter 1, solute carrier family 15 member 1
External IDsOMIM: 600544 MGI: 1861376 HomoloGene: 38006 GeneCards: SLC15A1
Orthologs
SpeciesHumanMouse
Entrez

6564

56643

Ensembl

ENSG00000088386

ENSMUSG00000025557

UniProt

P46059

Q9JIP7

RefSeq (mRNA)

NM_005073

NM_053079

RefSeq (protein)

NP_005064

NP_444309

Location (UCSC)Chr 13: 98.68 – 98.75 MbChr 14: 121.7 – 121.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
PepT 1 is a proton-coupled peptide cotransporter in epithelial cells.

Function

SLC15A1is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs.[5][7] Peptide transporter 1 functions in nutrient and drug transport have been studied using intestinal organoids.[8][9]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000088386 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025557 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: SLC15A1 Solute carrier family 15 (oligopeptide transporter), member 1".
  6. Liang R, Fei YJ, Prasad PD, Ramamoorthy S, Han H, Yang-Feng TL, Hediger MA, Ganapathy V, Leibach FH (March 1995). "Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization". J. Biol. Chem. 270 (12): 6456–63. doi:10.1074/jbc.270.12.6456. PMID 7896779.
  7. Adibi SA (July 1997). "The oligopeptide transporter (Pept-1) in human intestine: biology and function". Gastroenterology. 113 (1): 332–40. doi:10.1016/S0016-5085(97)70112-4. PMID 9207295.
  8. Zietek T, Rath E, Haller D, Daniel H (November 2015). "Intestinal organoids for assessing nutrient transport, sensing and incretin secretion". Scientific Reports. 5 (1): 16831. doi:10.1038/srep16831. PMC 4652176. PMID 26582215.
  9. Zietek T, Giesbertz P, Ewers M, Reichart F, Weinmüller M, Demir IE, et al. (2020). "Organoids to Study Intestinal Nutrient Transport, Drug Uptake and Metabolism – Update to the Human Model and Expansion of Applications". Frontiers in Bioengineering and Biotechnology. 8: 577656. doi:10.3389/fbioe.2020.577656. PMC 7516017. PMID 33015026.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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