Glucose-6-phosphate exchanger SLC37A1

Glucose-6-phosphate exchanger SLC37A1 is a protein that in humans is encoded by the SLC37A1 gene.[5] SLC37A1 locates to the membrane of the endoplasmic reticulum (ER), and is a glucose 6-phosphate:inorganic phosphate antiporter, transporting glucose 6-phosphate from the cytoplasm into the lumen of the ER, while transporting phosphate in the opposite direction.[6]

SLC37A1
Identifiers
AliasesSLC37A1, G3PP, solute carrier family 37 member 1
External IDsOMIM: 608094 MGI: 2446181 HomoloGene: 70486 GeneCards: SLC37A1
Orthologs
SpeciesHumanMouse
Entrez

54020

224674

Ensembl

ENSG00000160190

ENSMUSG00000024036

UniProt

P57057

Q8R070

RefSeq (mRNA)

NM_018964
NM_001320537

NM_001242427
NM_153062

RefSeq (protein)

NP_001307466
NP_061837

NP_001229356
NP_694702

Location (UCSC)Chr 21: 42.5 – 42.58 MbChr 17: 31.51 – 31.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Unlike the related SLC37A4 protein, SLC37A1 does not appear to be involved in blood glucose homeostasis,[7] but does appear to regulate phosphate levels in the milk of cows, with flow-on effects on the volume of milk produced.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000160190 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024036 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Solute carrier family 37 (glucose-6-phosphate transporter), member 1".
  6. "SLC37A1 - Glucose-6-phosphate exchanger SLC37A1 - Homo sapiens (Human) - SLC37A1 gene & protein".
  7. Pan CJ, Chen SY, Jun HS, Lin SR, Mansfield BC, Chou JY (2011). "SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters". PLOS ONE. 6 (9): e23157. Bibcode:2011PLoSO...623157P. doi:10.1371/journal.pone.0023157. PMC 3176764. PMID 21949678.
  8. Kemper KE, Littlejohn MD, Lopdell T, Hayes BJ, Bennett LE, Williams RP, Xu XQ, Visscher PM, Carrick MJ, Goddard ME (2016). "Leveraging genetically simple traits to identify small-effect variants for complex phenotypes". BMC Genomics. 17 (1): 858. doi:10.1186/s12864-016-3175-3. PMC 5094043. PMID 27809761.

Further reading


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