SMG1

Serine/threonine-protein kinase SMG1 is an enzyme that in humans is encoded by the SMG1 gene.[5][6][7][8] SMG1 belongs to the phosphatidylinositol 3-kinase-related kinase protein family.

SMG1
Identifiers
AliasesSMG1, 61E3.4, ATX, LIP, nonsense mediated mRNA decay associated PI3K related kinase, SMG1 nonsense mediated mRNA decay associated PI3K related kinase
External IDsOMIM: 607032 MGI: 1919742 HomoloGene: 56697 GeneCards: SMG1
Orthologs
SpeciesHumanMouse
Entrez

23049

233789

Ensembl

ENSG00000157106

ENSMUSG00000030655

UniProt

Q96Q15

Q8BKX6

RefSeq (mRNA)

NM_015092

NM_001031814
NM_177180

RefSeq (protein)

NP_055907

NP_001026984

Location (UCSC)Chr 16: 18.8 – 18.93 MbChr 7: 117.73 – 117.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternative spliced transcript variants have been described, but their full-length natures have not been determined.[8]

Interactions

SMG1 (gene) has been shown to interact with PRKCI[9] and UPF1.[10]

References

  1. GRCh38: Ensembl release 89: ENSG00000157106 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030655 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
  6. Denning G, Jamieson L, Maquat LE, Thompson EA, Fields AP (June 2001). "Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein". J. Biol. Chem. 276 (25): 22709–14. doi:10.1074/jbc.C100144200. PMID 11331269.
  7. Morita T, Yamashita A, Kashima I, Ogata K, Ishiura S, Ohno S (March 2007). "Distant N- and C-terminal domains are required for intrinsic kinase activity of SMG-1, a critical component of nonsense-mediated mRNA decay". J. Biol. Chem. 282 (11): 7799–808. doi:10.1074/jbc.M610159200. PMID 17229728.
  8. "Entrez Gene: SMG1 PI-3-kinase-related kinase SMG-1".
  9. Diaz-Meco MT, Municio MM, Sanchez P, Lozano J, Moscat J (January 1996). "Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo". Mol. Cell. Biol. 16 (1): 105–14. doi:10.1128/mcb.16.1.105. PMC 230983. PMID 8524286.
  10. Yamashita A, Ohnishi T, Kashima I, Taya Y, Ohno S (September 2001). "Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay". Genes Dev. 15 (17): 2215–28. doi:10.1101/gad.913001. PMC 312771. PMID 11544179.

Further reading


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