Sodium-dependent multivitamin transporter

Sodium-dependent multivitamin transporter is a protein that in humans is encoded by the SLC5A6 gene.[5][6][7]

SLC5A6
Identifiers
AliasesSLC5A6, SMVT, solute carrier family 5 member 6, NERIB
External IDsOMIM: 604024 MGI: 2660847 HomoloGene: 23277 GeneCards: SLC5A6
Orthologs
SpeciesHumanMouse
Entrez

8884

330064

Ensembl

ENSG00000138074

ENSMUSG00000006641

UniProt

Q9Y289

Q5U4D8

RefSeq (mRNA)

NM_021095

NM_001177621
NM_001177622
NM_177870
NM_001360022

RefSeq (protein)

NP_066918

NP_001171092
NP_001171093
NP_808538
NP_001346951

Location (UCSC)Chr 2: 27.2 – 27.21 MbChr 5: 31.19 – 31.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The SMVT is a transporter for pantothenic acid (vitamin B5) and biotin (vitamin B7) at the blood–brain barrier.[8] It is also a transporter for alpha lipoic acid[9] and iodide. Transport of these nutrients is competitive[10] and a surplus of a given nutrient may saturate the transporter and prevent the uptake of other nutrients.

References

  1. GRCh38: Ensembl release 89: ENSG00000138074 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000006641 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Prasad PD, Wang H, Kekuda R, Fujita T, Fei YJ, Devoe LD, et al. (March 1998). "Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate". The Journal of Biological Chemistry. 273 (13): 7501–6. doi:10.1074/jbc.273.13.7501. PMID 9516450.
  6. Wang H, Huang W, Fei YJ, Xia H, Yang-Feng TL, Leibach FH, et al. (May 1999). "Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization". The Journal of Biological Chemistry. 274 (21): 14875–83. doi:10.1074/jbc.274.21.14875. PMID 10329687.
  7. "Entrez Gene: SLC5A6 solute carrier family 5 (sodium-dependent vitamin transporter), member 6".
  8. Uchida Y, Ito K, Ohtsuki S, Kubo Y, Suzuki T, Terasaki T (July 2015). "Major involvement of Na(+) -dependent multivitamin transporter (SLC5A6/SMVT) in uptake of biotin and pantothenic acid by human brain capillary endothelial cells". Journal of Neurochemistry. 134 (1): 97–112. doi:10.1111/jnc.13092. PMID 25809983. S2CID 37721695.
  9. Quick M, Shi L (2015). "The sodium/multivitamin transporter: a multipotent system with therapeutic implications". Vitamins and Hormones. 98: 63–100. doi:10.1016/bs.vh.2014.12.003. PMC 5530880. PMID 25817866.
  10. Chirapu SR, Rotter CJ, Miller EL, Varma MV, Dow RL, Finn MG (31 March 2013). "High specificity in response of the sodium-dependent multivitamin transporter to derivatives of pantothenic acid". Current Topics in Medicinal Chemistry. 13 (7): 837–42. doi:10.2174/1568026611313070006. PMID 23578027.

Further reading

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