Sphingosine kinase 1

Sphingosine kinase 1 is an enzyme that in humans is encoded by the SPHK1 gene.[5][6]

SPHK1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSPHK1, SPHK, sphingosine kinase 1, SK1
External IDsOMIM: 603730 MGI: 1316649 HomoloGene: 39748 GeneCards: SPHK1
Orthologs
SpeciesHumanMouse
Entrez

8877

20698

Ensembl

ENSG00000176170

ENSMUSG00000061878

UniProt

Q9NYA1

Q8CI15

RefSeq (mRNA)

NM_001142601
NM_001142602
NM_021972
NM_182965
NM_001355139

RefSeq (protein)

NP_001136073
NP_001136074
NP_068807
NP_892010
NP_001342068

Location (UCSC)Chr 17: 76.38 – 76.39 MbChr 11: 116.42 – 116.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sphingosine kinase 1 phosphorylates sphingosine to sphingosine-1-phosphate (S1P). SK1 is normally a cytosolic protein but is recruited to membranes rich in phosphatidate (PA), a product of phospholipase D (PLD).[7]

Sphingosine-1-phosphate (S1P) is a novel lipid messenger with both intracellular and extracellular functions. Intracellularly, it regulates proliferation and survival, and extracellularly, it is a ligand for EDG1. Various stimuli increase cellular levels of S1P by activation of sphingosine kinase (SPHK), the enzyme that catalyzes the phosphorylation of sphingosine. Competitive inhibitors of SPHK block formation of S1P and selectively inhibit cellular proliferation induced by a variety of factors, including platelet-derived growth factor and serum.[6]

Interactions

SPHK1 has been shown to interact with TRAF2.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000176170 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000061878 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kohama T, Olivera A, Edsall L, Nagiec MM, Dickson R, Spiegel S (Sep 1998). "Molecular cloning and functional characterization of murine sphingosine kinase". The Journal of Biological Chemistry. 273 (37): 23722–8. doi:10.1074/jbc.273.37.23722. PMID 9726979.
  6. "Entrez Gene: SPHK1 sphingosine kinase 1".
  7. Delon C, Manifava M, Wood E, Thompson D, Krugmann S, Pyne S, Ktistakis NT (2004). "Sphingosine Kinase 1 Is an Intracellular Effector of Phosphatidic Acid". The Journal of Biological Chemistry. 279 (43): 44763–44774. doi:10.1074/jbc.M405771200. PMID 15310762.
  8. Xia P, Wang L, Moretti PA, Albanese N, Chai F, Pitson SM, D'Andrea RJ, Gamble JR, Vadas MA (Mar 2002). "Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling". The Journal of Biological Chemistry. 277 (10): 7996–8003. doi:10.1074/jbc.M111423200. PMID 11777919.

Further reading

  • Paugh SW, Kapitonov D, Spiegel S (2007-11-08). "Sphingosine kinase 1". UCSD Nature Molecule Pages. Signaling Gateway: University of California San Diego (UCSD) and Nature Publishing Group. doi:10.1038/mp.a002219.01. Retrieved 2008-09-15.


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