Sulfalene

Sulfalene
Clinical data
Trade names	Eadazine, Kelfizina, Kelfizine W, Longum
Other names	Sulfametopyrazine
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral[1]
ATC code	J01ED02 (WHO) QJ01EQ19 (WHO);
Pharmacokinetic data
Protein binding	60 to 80%[1]
Elimination half-life	60 to 65 hours[1]
Excretion	Urinary[1]
Identifiers
	IUPAC name 4-Amino-N-(3-methoxypyrazinyl)benzenesulfonamide;
CAS Number	152-47-6 ;
PubChem CID	9047;
DrugBank	DB00664 ;
ChemSpider	8695 ;
UNII	T6BL4ZC15G;
KEGG	D01216 ;
CompTox Dashboard (EPA)	DTXSID2046179 ;
ECHA InfoCard	100.005.278
Chemical and physical data
Formula	C11H12N4O3S
Molar mass	280.30 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=S(=O)(Nc1nccnc1OC)c2ccc(N)cc2;
	InChI InChI=1S/C11H12N4O3S/c1-18-11-10(13-6-7-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,15) ; Key:KXRZBTAEDBELFD-UHFFFAOYSA-N ;
	(verify)

Sulfalene (INN, USAN) or sulfametopyrazine (BAN) is a long-acting sulfonamide antibacterial used for the treatment of chronic bronchitis, urinary tract infections and malaria.[2][3] As of 2014 there were only two countries in which it is currently still marketed: Thailand and Ireland.[3]

It was discovered by researchers at Farmitalia and first published in 1960 and was marketed as Kelfizina.[4][5]

References

"Sulfalene". MIMS Drug Information System. Retrieved 26 August 2011.
DrugBank DB00664
Brayfield A, ed. (9 May 2013). "Sulfametopyrazine". Martindale: The Complete Drug Reference. Pharmaceutical Press. Retrieved 28 March 2014.
Baruffa G (1966). "Clinical trials in Plasmodium falciparum malaria with a long-acting sulphonamide". Transactions of the Royal Society of Tropical Medicine and Hygiene. 60 (2): 222–4. doi:10.1016/0035-9203(66)90030-7. PMID 5332105.
Per prior citation, the first publication: Camerino B, Palamidessi G (1960). "Derivati della parazina II. Sulfonamdopir". Gazz Chim Ital (in Italian). 90: 1802–1815.

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