UGCG

Ceramide glucosyltransferase is an enzyme that in humans is encoded by the UGCG gene.[5][6][7]

UGCG
Identifiers
AliasesUGCG, GCS, GLCT1, UDP-glucose ceramide glucosyltransferase
External IDsOMIM: 602874 MGI: 1332243 HomoloGene: 37763 GeneCards: UGCG
Orthologs
SpeciesHumanMouse
Entrez

7357

22234

Ensembl

ENSG00000148154

ENSMUSG00000028381

UniProt

Q16739

O88693

RefSeq (mRNA)

NM_003358

NM_011673

RefSeq (protein)

NP_003349
NP_003349.1

NP_035803

Location (UCSC)Chr 9: 111.9 – 111.94 MbChr 4: 59.19 – 59.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glycosphingolipids (GSLs) are a group of membrane components that contain lipid and sugar moieties. They are present in essentially all animal cells and are believed to have important roles in various cellular processes. UDP-glucose ceramide glucosyltransferase catalyzes the first glycosylation step in glycosphingolipid biosynthesis. The product, glucosylceramide, is the core structure of more than 300 GSLs. UGCG is widely expressed and transcription is upregulated during keratinocyte differentiation.[7]

Interactions

UGCG has been shown to interact with RTN1.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000148154 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028381 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ichikawa S, Sakiyama H, Suzuki G, Hidari KI, Hirabayashi Y (Jul 1996). "Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis". Proc Natl Acad Sci U S A. 93 (10): 4638–4643. Bibcode:1996PNAS...93.4638I. doi:10.1073/pnas.93.10.4638. PMC 39331. PMID 8643456.
  6. Ichikawa S, Ozawa K, Hirabayashi Y (Jun 1998). "Assignment of a UDP-glucose:ceramide glucosyltransferase gene (UGCG) to human chromosome band 9q31 by in situ hybridization". Cytogenet Cell Genet. 79 (3–4): 233–234. doi:10.1159/000134731. PMID 9605861.
  7. "Entrez Gene: UGCG UDP-glucose ceramide glucosyltransferase".
  8. Di Sano, Federica; Fazi Barbara; Citro Gennaro; Lovat Penny E; Cesareni Gianni; Piacentini Mauro (Jul 2003). "Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells". Cancer Res. 63 (14): 3860–3865. ISSN 0008-5472. PMID 12873973.

Further reading

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.