VUF-5681

VUF-5681
Names
	Preferred IUPAC name 4-[3-(1H-Imidazol-5-yl)propyl]piperidine
Identifiers
CAS Number	768358-61-8 ;
3D model (JSmol)	Interactive image;
ChemSpider	8505701 ;
PubChem CID	10330240;
UNII	WR5V5TB2TR ;
	InChI InChI=1S/C11H19N3/c1(3-11-8-13-9-14-11)2-10-4-6-12-7-5-10/h8-10,12H,1-7H2,(H,13,14) Key: YPGRNKJNOSUCLY-UHFFFAOYSA-N ; InChI=1/C11H19N3/c1(3-11-8-13-9-14-11)2-10-4-6-12-7-5-10/h8-10,12H,1-7H2,(H,13,14) Key: YPGRNKJNOSUCLY-UHFFFAOYAZ;
	SMILES C1CNCCC1CCCC2=CN=CN2;
Properties
Chemical formula	C11H19N3
Molar mass	193.288 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

VUF-5681 is a potent and selective histamine antagonist which binds selectively to the H₃ subtype.[1] However while VUF-5681 blocks the activity of more potent H₃ agonists, recent studies suggest that it may have some weak partial agonist activity when administered by itself.[2]

References

Moreno-Delgado D, Torrent A, Gómez-Ramírez J, de Esch I, Blanco I, Ortiz J (September 2006). "Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway". Neuropharmacology. 51 (3): 517–23. doi:10.1016/j.neuropharm.2006.04.010. PMID 16769092. S2CID 25209099.
Baker JG (June 2008). "Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells". BMC Pharmacology. 8: 9. doi:10.1186/1471-2210-8-9. PMC 2430196. PMID 18538007.

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[1] Moreno-Delgado D, Torrent A, Gómez-Ramírez J, de Esch I, Blanco I, Ortiz J (September 2006). "Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway". Neuropharmacology. 51 (3): 517–23. doi:10.1016/j.neuropharm.2006.04.010. PMID 16769092. S2CID 25209099.

[2] Baker JG (June 2008). "Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells". BMC Pharmacology. 8: 9. doi:10.1186/1471-2210-8-9. PMC 2430196. PMID 18538007.