Voglibose

Voglibose (INN and USAN, trade name Voglib, marketed by Mascot Health Series) is an alpha-glucosidase inhibitor used for lowering postprandial blood glucose levels in people with diabetes mellitus.[1] Voglibose delays the absorption of glucose thereby reducing the risk of macrovascular complications. Voglibose is a research product of Takeda Pharmaceutical Company, Japan's largest pharmaceutical company. Vogilbose was discovered in 1981, and was first launched in Japan in 1994,[2] under the trade name BASEN, to improve postprandial hyperglycemia in diabetes mellitus.[3]

Voglibose
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
  • (1S,2S,3R,4S,5S)-5-(1,3-dihydroxypropan-2-ylamino)-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetraol
CAS Number
PubChem CID
DrugBank
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UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC10H21NO7
Molar mass267.278 g·mol−1
3D model (JSmol)
  • OC[C@@]1(O)C[C@H](NC(CO)CO)[C@H](O)[C@@H](O)[C@@H]1O
  • InChI=1S/C10H21NO7/c12-2-5(3-13)11-6-1-10(18,4-14)9(17)8(16)7(6)15/h5-9,11-18H,1-4H2/t6-,7-,8+,9-,10-/m0/s1 checkY
  • Key:FZNCGRZWXLXZSZ-CIQUZCHMSA-N checkY
  (verify)

Postprandial hyperglycemia (PPHG) is primarily due to first phase insulin secretion. Alpha glucosidase inhibitors delay glucose absorption at the intestine level and thereby prevent sudden surge of glucose after a meal.[2]

There are three major drugs which belong to this class, acarbose, miglitol and voglibose,[2] of which voglibose is the newest.

Efficacy

A Cochrane systematic review assessed the effect of alpha-glucosidase inhibitors in people with impaired glucose tolerance, impaired fasting blood glucose, elevated glycated hemoglobin A1c (HbA1c).[4] It was found that there was no conclusive evidence that voglibose compared to diet and exercise or placebo reduced incidence of diabetes mellitus type 2, improved all-cause mortality, reduced or increased risk of cardiovascular mortality, serious or non-serious adverse events, non-fatal stroke, congestive heart failure, or non-fatal myocardial infarction.[4]

References
  1. Chen X, Zheng Y, Shen Y (2006). "Voglibose (Basen, AO-128), one of the most important alpha-glucosidase inhibitors". Current Medicinal Chemistry. 13 (1): 109–116. doi:10.2174/092986706789803035. PMID 16457643.
  2. Dabhi AS, Bhatt NR, Shah MJ (December 2013). "Voglibose: an alpha glucosidase inhibitor". Journal of Clinical and Diagnostic Research. 7 (12): 3023–3027. doi:10.7860/JCDR/2013/6373.3838. PMC 3919386. PMID 24551718.
  3. "Voglibose". AdisInsight. Springer Nature Switzerland AG.
  4. Moelands SV, Lucassen PL, Akkermans RP, De Grauw WJ, Van de Laar FA (December 2018). Cochrane Metabolic and Endocrine Disorders Group (ed.). "Alpha-glucosidase inhibitors for prevention or delay of type 2 diabetes mellitus and its associated complications in people at increased risk of developing type 2 diabetes mellitus". The Cochrane Database of Systematic Reviews. 2018 (12): CD005061. doi:10.1002/14651858.CD005061.pub3. PMC 6517235. PMID 30592787.

Further reading
  • Miller CK (2004). "New therapeutic options in the treatment of diabetes mellitus". In Greenstein B (ed.). Clinical Pharmacology for nurses (17th ed.). Elsevier Limited, Churchill Livingstone.
  • Wilson L (1997). Mehra IV (ed.). Managing the Patient with Type II Diabetes. Aspen Publishers. pp. 62–63. ISBN 978-0-8342-1018-9.
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