WNT2B

Protein Wnt-2b (formerly Wnt13[5]) is a protein that in humans is encoded by the WNT2B gene.[6][7][8]

WNT2B
Identifiers
AliasesWNT2B, WNT13, Wnt family member 2B
External IDsOMIM: 601968 MGI: 1261834 HomoloGene: 22526 GeneCards: WNT2B
Orthologs
SpeciesHumanMouse
Entrez

7482

22414

Ensembl

ENSG00000134245

ENSMUSG00000027840

UniProt

Q93097

O70283

RefSeq (mRNA)

NM_024494
NM_001291880
NM_004185

NM_009520

RefSeq (protein)

NP_001278809
NP_004176
NP_078613

NP_033546

Location (UCSC)Chr 1: 112.47 – 112.53 MbChr 3: 104.85 – 104.87 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as human carcinogenesis. This gene produces two alternative transcript variants.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000134245 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027840 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kubo F, Takeichi M, Nakagawa S (2003). "Wnt2b controls retinal cell differentiation at the ciliary marginal zone". Development. 130 (3): 587–98. doi:10.1242/dev.00244. PMID 12490564.
  6. Katoh M, Hirai M, Sugimura T, Terada M (Oct 1996). "Cloning, expression and chromosomal localization of Wnt-13, a novel member of the Wnt gene family". Oncogene. 13 (4): 873–6. PMID 8761309.
  7. Katoh M, Kirikoshi H, Saitoh T, Sagara N, Koike J (Sep 2000). "Alternative splicing of the WNT-2B/WNT-13 gene". Biochem Biophys Res Commun. 275 (1): 209–16. doi:10.1006/bbrc.2000.3252. PMID 10944466.
  8. "Entrez Gene: WNT2B wingless-type MMTV integration site family, member 2B".

Further reading



This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.