WNT3

Proto-oncogene protein Wnt-3 is a protein that in humans is encoded by the WNT3 gene.[5][6]

WNT3
Identifiers
Aliases	WNT3, INT4, TETAMS, Wnt family member 3
External IDs	OMIM: 165330 MGI: 98955 HomoloGene: 22527 GeneCards: WNT3
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.31-q21.32 Start 46,762,506 bp[1] End 46,833,154 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 E1|11 67.5 cM Start 103,664,976 bp[2] End 103,708,783 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen hypothalamus dorsolateral prefrontal cortex substantia nigra right lobe of liver Brodmann area 9 prefrontal cortex amygdala superior frontal gyrus nucleus accumbens Top expressed in surface ectoderm rhombic lip lip pretectal area intestinal villus enamel knot cerebellar cortex lateral habenular nucleus medial habenular nucleus mesoderm More reference expression data BioGPS More reference expression data
Gene ontology Molecular function receptor ligand activity protein domain specific binding frizzled binding protein binding signaling receptor binding Cellular component cytoplasm endocytic vesicle membrane Wnt signalosome endoplasmic reticulum lumen plasma membrane extracellular region Golgi lumen extracellular exosome extracellular space extracellular matrix Biological process cellular response to retinoic acid cell fate commitment Spemann organizer formation at the anterior end of the primitive streak head morphogenesis limb bud formation mammary gland epithelium development anatomical structure formation involved in morphogenesis mesoderm formation positive regulation of collateral sprouting in absence of injury negative regulation of axon extension involved in axon guidance dorsal/ventral axis specification axon guidance limb development multicellular organism development positive regulation of Wnt signaling pathway gamete generation canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation canonical Wnt signaling pathway involved in osteoblast differentiation cell morphogenesis canonical Wnt signaling pathway anterior/posterior axis specification embryonic forelimb morphogenesis anterior/posterior pattern specification embryonic hindlimb morphogenesis Wnt signaling pathway positive regulation of gene expression regulation of neurogenesis stem cell proliferation canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation canonical Wnt signaling pathway involved in stem cell proliferation neuron differentiation regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7473 22415 Ensembl ENSG00000108379 ENSG00000277641 ENSG00000277626 ENSMUSG00000000125 UniProt P56703 P17553 RefSeq (mRNA) NM_030753 NM_009521 RefSeq (protein) NP_110380 NP_033547 Location (UCSC) Chr 17: 46.76 – 46.83 Mb Chr 11: 103.66 – 103.71 Mb PubMed search [3] [4]
Wikidata
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The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region.[6]