Zinc finger FYVE domain-containing protein 9

ZFYVE9
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1DEV, 1MK2, 4BKW
Identifiers
Aliases	ZFYVE9, MADHIP, NSP, PPP1R173, SARA, SMADIP, zinc finger FYVE-type containing 9
External IDs	OMIM: 603755 MGI: 2652838 HomoloGene: 3527 GeneCards: ZFYVE9
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	52,348,671 bp[1]
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)[2]
End	108,637,995 bp[2]
RNA expression pattern
	Top expressed in
	Achilles tendon; ; prefrontal cortex; ; gastrocnemius muscle; ; cerebellar cortex; ; cerebellar hemisphere; ; islet of Langerhans; ; internal globus pallidus; ; Brodmann area 9; ; cerebellar vermis; ; Brodmann area 46;
	Top expressed in
	skeletal muscle tissue; ; quadriceps femoris muscle; ; cerebellar cortex; ; hippocampus proper; ; superior frontal gyrus; ; zone of skin; ; hypothalamus; ; olfactory bulb; ; esophagus; ; ganglionic eminence;
	More reference expression data
	n/a
Gene ontology
Molecular function	1-phosphatidylinositol binding; serine-type peptidase activity; protein binding; metal ion binding; protein domain specific binding;
Cellular component	cytoplasm; endosome; early endosome; early endosome membrane; membrane; cytosol; intracellular membrane-bounded organelle; protein-containing complex;
Biological process	endocytosis; transforming growth factor beta receptor signaling pathway; proteolysis; endosomal transport;
	Sources:Amigo / QuickGO
Orthologs
	9372
	230597
	ENSG00000157077
	ENSMUSG00000034557
	O95405
	n/a
	NM_004799; NM_007323; NM_007324
	NM_183300; NM_001347163; NM_001384118
	NP_004790; NP_015563
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger FYVE domain-containing protein 9 or SARA (SMAD anchor for receptor activation) is a protein that in humans is encoded by the ZFYVE9 gene.[5] SARA contains a double zinc finger (FYVE domain).

SARA is an anchoring protein involved in TGF beta signaling. It binds to the MH2 domain of the R-SMADs SMAD2 and SMAD3 as well as the type I TGF beta receptors.[6] It facilitates the phosphorylation of the R-SMAD, which subsequently dissociates from SARA and the receptor and binds a coSMAD where they enter the nucleus as transcription factors.

References

GRCh38: Ensembl release 89: ENSG00000157077 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000034557 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL (December 1998). "SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor". Cell. 95 (6): 779–791. doi:10.1016/S0092-8674(00)81701-8. PMID 9865696. S2CID 6194655.
Lin HK, Bergmann S, Pandolfi PP (September 2004). "Cytoplasmic PML function in TGF-beta signalling". Nature. 431 (7005): 205–211. Bibcode:2004Natur.431..205L. doi:10.1038/nature02783. PMID 15356634. S2CID 4301789.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Zinc finger FYVE domain-containing protein 9

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000157077 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034557 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9865696-5] Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL (December 1998). "SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor". Cell. 95 (6): 779–791. doi:10.1016/S0092-8674(00)81701-8. PMID 9865696. S2CID 6194655.

[pmid15356634-6] Lin HK, Bergmann S, Pandolfi PP (September 2004). "Cytoplasmic PML function in TGF-beta signalling". Nature. 431 (7005): 205–211. Bibcode:2004Natur.431..205L. doi:10.1038/nature02783. PMID 15356634. S2CID 4301789.