Zoopharmacognosy

Zoopharmacognosy is a behaviour in which non-human animals self-medicate by selecting and ingesting or topically applying plants, soils and insects with medicinal properties, to prevent or reduce the harmful effects of pathogens, toxins, and even other animals.[1][2] The term derives from Greek roots zoo ("animal"), pharmacon ("drug, medicine"), and gnosy ("knowing").

For use of psychoactive substances by animals for pleasure, see Recreational drug use in animals.
For the effect of psychoactive drugs on animals conducted via animal testing, see Effect of psychoactive drugs on animals.
See also: Venom § Venom resistant animals
A cat eating grass – an example of zoopharmacognosy

An example of zoopharmacognosy occurs when dogs eat grass to induce vomiting. However, the behaviour is more diverse than this. Animals ingest or apply non-foods such as clay, charcoal and even toxic plants and invertebrates, apparently to prevent parasitic infestation or poisoning.[3]

Whether animals truly self-medicate remains a somewhat controversial subject because early evidence is mostly circumstantial or anecdotal.[4] However, more recent examinations have adopted an experimental, hypothesis-driven approach.

The methods by which animals self-medicate vary, but can be classified according to function as prophylactic (preventative, before infection or poisoning) or therapeutic (after infection, to combat the pathogen or poisoning).[4] The behaviour is believed to have widespread adaptive significance.[5]

History and etymology

In 1978, Janzen suggested that vertebrate herbivores might benefit medicinally from the secondary metabolites in their plant food.[6]

In 1993, the term "zoopharmacognosy" was coined, derived from the Greek roots zoo ("animal"), pharma ("drug"), and gnosy ("knowing").[7] The term gained popularity from academic works[4] and in a book by Cindy Engel entitled Wild Health: How Animals Keep Themselves Well and What We Can Learn from Them.[8]

Mechanisms

The anti-parasitic effect of zoopharmacognosy could occur by at least two mechanisms, namely demonstrated through the modes of deglutition or ingestion. First, ingested material may have pharmacological antiparasitic properties, such as phytochemicals decreasing the ability of worms to attach to the mucosal lining of the intestines or chemotaxis attracting worms into the folds of leaves. Additionally, many plants have trichomes, often presented as hooked and spiky hairs, that can attach to parasites and dislodge them from the intestines. Another possible mode of action is that the ingested material may initiate a purging response of the gastrointestinal tract by rapidly inducing diarrhoea. This substantially decreases gut transit time, causing worm expulsion and interruption in the life cycle of parasites. This, or a similar, mechanism could explain undigested materials in the faeces of various animals such as birds, carnivores and primates.[9]

The topical application of materials is often used by animals to treat wounds or repel insects.[10] When plant leaves are chewed and then directly rubbed onto fur, compounds from said leaves are released for use. These compounds can often be analgesic or antiparasitic in nature. In regards to an insect repellant, the secondary metabolites traditionally used by plants to deter herbivores and insects from eating them[11] can be used by animals as a protective measure. By interfering with neuroreceptors, these secondary metabolites can specifically act as olfactory cues for insects to avoid a certain source.[12]

Methods of self-medication

The three reported methods of self-medication are deglutition, ingestion, and topical application. When using one of these methods while appearing well, an animal may be using self-medication as a prophylactic measure. When it is unwell, the animal could be using self-medication as a curative measure.

Deglutition

Some examples of zoopharmacognosy are demonstrated when animals, namely apes, swallow materials whole instead of chewing and ingesting them.

Chimpanzees

Wild chimpanzees sometimes seek leaves of the Aspilia plant. These contain thiarubrine-A, a chemical active against intestinal nematode parasites. Because this compound is quickly broken down by the stomach, chimpanzees will pick up the Aspilia leaves and, rather than chewing them, they roll them around in their mouths, sometimes for as long as 25 seconds. They then swallow the capsule-like leaves whole. Afterwards, the trichomes of the leaves can attach to any intestinal parasites, namely the nodular worm (Oesophagostomum stephanostomum) and tapeworm (Bertiella studeri), and allow the chimpanzee to physically expel the parasites.[13] As many as 15 to 35 Aspilia leaves may be used in each bout of this behaviour, particularly in the rainy season when there is an abundance of many parasitic larvae that can cause an increased risk of infection.[14]

Chimpanzees sometimes eat the leaves of the herbaceous Desmodium gangeticum. Undigested, non-chewed leaves were recovered in 4% of faecal samples of wild chimpanzees and clumps of sharp-edged grass leaves in 2%. The leaves have a rough surface or sharp-edges and the fact they were not chewed and excreted whole indicates they were not ingested for nutritional purposes. Furthermore, this leaf-swallowing was restricted to the rainy season when parasite re-infections are more common, and parasitic worms (Oesophagostomum stephanostomum) were found together with the leaves.[9]

Bonobos sometimes swallow non-chewed stem-strips of Manniophyton fulvum. Despite the plant being abundantly available all year, M. fulvum is ingested only at specific times, in small amounts, and by a small proportion of bonobos in each group, demonstrating that it is indeed only utilized when the bonobos are unwell.[15]

Monkeys

Tamarins were observed swallowing the large seeds of the fruit they regularly ingest. Although they are consumed along with the rest of the fruit, it must be noted that these seeds have no nutritional value for the monkeys. Since tamarins are routinely infected by trematodes, cestodes, nematodes, and acanthocephalans, there is speculation that the deliberate swallowing of these large seeds can help dislodge the parasites from the monkey's body.[16]

Bears

Similar to the wild chimpanzees, Alaskan brown bears will swallow whole Carex leaves in the springtime to ensure the complete expulsion of parasites during their hibernation.[17] Specifically, as tapeworms thrive off previously digested nutrients in the gut, the rough Carex leaves will lacerate their scolices, facilitating the defecation process. The proactive swallowing of these leaves will ensure low levels of active parasites within a hibernating bear.

Ingestion

Many examples of zoopharmacognosy involve an animal ingesting a substance with (potential) medicinal properties.

Birds
A group of various species of parrot, including blue-and-yellow, scarlet and chestnut-fronted macaws, mealy amazons, blue-headed parrots and an orange-cheeked parrot consuming clay in the Tambopata National Reserve, Peru

Many parrot species in the Americas, Africa, and Papua New Guinea consume kaolin or clay, which both releases minerals and absorbs toxic compounds from the gut.[18]

Great bustards eat blister beetles of the genus Meloe maybe to decrease parasite load in the digestive system;[19] cantharidin, the toxic compound in blister beetles, can kill a great bustard if too many beetles are ingested.[20] Great bustards may eat toxic blister beetles of the genus Meloe to increase the sexual arousal of males.[21] Some plants selected in the mating season showed in-vitro activity against laboratory models of parasites and pathogens.[22]

Invertebrates

Woolly bear caterpillars (Grammia incorrupta) are sometimes lethally endoparasitised by tachinid flies. The caterpillars ingest plant toxins called pyrrolizidine alkaloids, which improve survival by conferring resistance against the flies. Crucially, parasitised caterpillars are more likely than non-parasitised caterpillars to specifically ingest large amounts of pyrrolizidine alkaloids, and excessive ingestion of these toxins reduces the survival of non-parasitised caterpillars. These three findings are all consistent with the adaptive plasticity theory.[6]

The tobacco hornworm ingests nicotine which reduces colony growth and toxicity of Bacillus thuringiensis, leading to increased survival of the hornworm.[14]

Ants

Ants infected with Beauveria bassiana, a fungus, selectively consume harmful substances (reactive oxygen species, ROS) upon exposure to a fungal pathogen, yet avoid these in the absence of infection.[23]

Mammals
A variety of simian species have been observed to medicate themselves when ill using materials such as plants.
A conceptual representation of how pre- and post-ingestive events control the manifestation of self-medicative behavior in mammalian herbivores[24]

Great apes often consume plants that have no nutritional values but which have beneficial effects on gut acidity or combat intestinal parasitic infection.[1]

Chimpanzees sometimes select bitter leaves for chewing. Parasite infection drops noticeably after chimpanzees chew leaves of pith (Vernonia amygdalina), which contain sesquiterpene lactones and steroid glucosides that are particularly effective against schistosoma, plasmodium and Leishmania.[25] Specifically, these compounds can induce paralysis within the parasites and impair its ability to absorb nutrients, move, and reproduce.[26] Chimpanzees do not consume bitter on a regular basis, but when they do, it is often in small amounts by individuals that appear ill.[27] Jane Goodall witnessed chimpanzees eating particular bushes, apparently to make themselves vomit.

Chimpanzees, bonobos, and gorillas eat the fruits of Aframomum angustifolium. Laboratory assays of homogenized fruit and seed extracts show significant anti-microbial activity.[28] Illustrating the medicinal knowledge of some species, apes have been observed selecting a particular part of a medicinal plant by taking off leaves and breaking the stem to suck out the juice.[29]

Anubis baboons (Papio anubis) and hamadryas baboons (Papio hamadryas) in Ethiopia use fruits and leaves of Balanites aegyptiaca to control schistosomiasis.[30] Its fruits contain diosgenin, a hormone precursor that presumably hinders the development of schistosomes.[4]

African elephants (Loxodonta africana) apparently self-medicate to induce labour by chewing on the leaves of a particular tree from the family Boraginaceae; Kenyan women brew a tea from this tree for the same purpose.[31]

White-nosed coatis (Nasua narica) in Panama take the menthol-scented resin from freshly scraped bark of Trattinnickia aspera (Burseraceae) and vigorously rub it into their own fur or that of other coatis, possibly to kill ectoparasites such as fleas, ticks, and lice, as well as biting insects such as mosquitoes;[32] the resin contains triterpenes α- and β-amyrin, the eudesmane derivative β-selinene, and the sesquiterpene lactone 8β-hydroxyasterolide.[28]

Domestic cats and dogs often select and ingest plant material, apparently to induce vomiting.[33]

Indian wild boars selectively dig up and eat the roots of pigweed which humans use as an anthelmintic. Mexican folklore indicates that pigs eat pomegranate roots because they contain an alkaloid that is toxic to tapeworms.[34]

A study on domestic sheep (Ovis aries) has provided clear experimental proof of self-medication via individual learning.[6] Lambs in a treatment group were allowed to consume foods and toxins (grain, tannins, oxalic acid) that lead to malaise (negative internal states) and then allowed to eat a substance known to alleviate each malaise (sodium bentonite, polyethylene glycol and dicalcium phosphate, respectively). Control lambs ate the same foods and medicines, but this was disassociated temporally so they did not recuperate from the illness. After the conditioning, lambs were fed grain or food with tannins or oxalates and then allowed to choose the three medicines. The treatment animals preferred to eat the specific compound known to rectify the state of malaise induced by the food previously ingested. However, control animals did not change their pattern of use of the medicines, irrespective of the food consumed before the choice.[35] Other ruminants learn to self-medicate against gastrointestinal parasites by increasing consumption of plant secondary compounds with antiparasitic actions.[24]

Standard laboratory cages prevent mice from performing several natural behaviours for which they are highly motivated. As a consequence, laboratory mice sometimes develop abnormal behaviours indicative of emotional disorders such as depression and anxiety. To improve welfare, these cages are sometimes enriched with items such as nesting material, shelters and running wheels. Sherwin and Olsson[36] tested whether such enrichment influenced the consumption of Midazolam, a drug widely used to treat anxiety in humans. Mice in standard cages, standard cages but with unpredictable husbandry, or enriched cages, were given a choice of drinking either non-drugged water or a solution of the Midazolam. Mice in the standard and unpredictable cages drank a greater proportion of the anxiolytic solution than mice from enriched cages, presumably because they had been experiencing greater anxiety. Early studies indicated that autoimmune (MRL/lpr) mice readily consume solutions with cyclophosphamide, an immunosuppressive drug that prevents inflammatory damage to internal organs. However, further studies provided contradictory evidence.[1]

During the cold and rainy seasons, the crested porcupines (Hystrix cristata) in Central Italy tend to become infected by seven different species of ectoparasites and seven different species of endoparasites.[37] During this time, it is observed that these porcupine populations actively sought out a rather large variety of medicinal plants, mostly with antiparasitic properties, to consume. When ingested, these plants appeared to be relieving the symptoms of the infections, such as inflammation.

Geophagy
Main article: Geophagy

Many animals eat soil or clay, a behaviour known as geophagy. Clay is the primary ingredient of kaolin.[38] It has been proposed that for primates, there are four hypotheses relating to geophagy in alleviating gastrointestinal disorders or upsets:[39]

  1. soils adsorb toxins such as phenolics and secondary metabolites
  2. soil ingestion has an antacid action and adjusts the gut pH
  3. soils act as an antidiarrhoeal agent
  4. soils counteract the effects of endoparasites.

Furthermore, two hypotheses pertain to geophagy in supplementing minerals and elements:

  1. soils supplement nutrient-poor diets
  2. soils provide extra iron at high altitudes

Tapirs, forest elephants, colobus monkeys, mountain gorillas and chimpanzees seek out and eat clay, which absorbs intestinal bacteria and their toxins and alleviates stomach upset and diarrhoea.[40] Cattle eat clay-rich termite mound soil, which deactivates ingested pathogens or fruit toxins.[1]

Topical application

Some animals apply substances with medicinal properties to their skin. Again, this can be prophylactic or curative. In some cases, this is known as self-anointing.

Mammals

A female capuchin monkey in captivity was observed using tools covered in a sugar-based syrup to groom her wounds and those of her infant.[41][42]

North American brown bears (Ursos arctos) make a paste of Osha roots (Ligusticum porteri) and saliva and rub it through their fur to repel insects or soothe bites. This plant, locally known as "bear root", contains 105 active compounds, such as coumarins that may repel insects when topically applied. Navajo Indians are said to have learned to use this root medicinally from the bear for treating stomach aches and infections.[28][43][44]

A range of primates rub millipedes onto their fur and skin; millipedes contain benzoquinones, compounds known to be potently repellent to insects.[45][46][47] As the millipede secretions are also psychoactive, the behavior may also be a form of recreational drug use in animals.[48][49]

Tufted capuchins (Cebus apella) rub various parts of their body with carpenter ants (Camponotus rufipes) or allow the ants to crawl over them, in a behaviour called anting. The capuchins often combine anting with urinating into their hands and mixing the ants with the urine.[50]

Callicebus oenanthes have been observed rubbing leaves of Piper aduncum on their furs and abdominal areas. Since these leaves contain insecticides like dillapiole and phenylpropanoids, it is speculated that this fur-rubbing is an indication of a preventative measure to ward off insects.[51] Additionally, another species of titi monkeys, Plecturocebus cupreus, were seen rubbing their furs with the leaves of Psychotria, whose compounds have antiviral, antifungal, and analgesic properties.[10]

Birds

More than 200 species of song birds wipe ants, a behaviour known as anting.[14] Birds either grasp ants in their bill and wipe them vigorously along the spine of each feather down to the base, or sometimes roll in ant hills twisting and turning so the ants crawl through their feathers. Birds most commonly use ants that spray formic acid. In laboratory tests, this acid is harmful to feather lice. Its vapour alone can kill them.

Some birds select nesting material rich in anti-microbial agents that may protect themselves and their young from harmful infestations or infections. European starlings (Sturnus vulgaris) preferentially select and line their nests with wild carrot (Daucus carota); chicks from nests lined with this have greater levels of haemoglobin compared to those from nests which are not, although there is no difference in the weight or feather development of the chicks. Laboratory studies show that wild carrot substantially reduces the emergence of the instars of mites.[52] House sparrows (Passer domesticus) have been observed to line their nests with materials from the neem tree (Azadirachta indica) but change to quinine-rich leaves of the Krishnachua tree (Caesalpinia pulcherrima) during an outbreak of malaria; quinine controls the symptoms of malaria.[28][53]

Social zoopharmacognosy
Wood ants incorporate resin into their nest to inhibit the growth of microorganisms.

Zoopharmacognosy is not always exhibited in a way that benefits the individual. Sometimes the target of the medication is the group or the colony.

Wood ants (Formica paralugubris) often incorporate large quantities of solidified conifer resin into their nests. Laboratory studies have shown this resin inhibits the growth of bacteria and fungi in a context mimicking natural conditions.[54] The ants show a strong preference for resin over twigs and stones, which are building materials commonly available in their environment. There is seasonal variation in the foraging of ants: the preference for resin over twigs is more pronounced in spring than in summer, whereas in autumn the ants collect twigs and resin at equal rates. The relative collection rate of resin versus stones does not depend on infection with the entomopathogenic fungus Metarhizium anisopliae in laboratory conditions, indicating the resin collection is prophylactic rather than therapeutic.[55]

Honey bees also incorporate plant-produced resins into their nest architecture, which can reduce chronic elevation of an individual bee's immune response. When colonies of honey bees are challenged with the fungal parasite (Ascophaera apis), the bees increase their resin foraging. Additionally, colonies experimentally enriched with resin have decreased infection intensities of the fungus.[56]

Transgenerational zoopharmacognosy
Adult monarch butterflies lay their eggs on toxic plants to reduce parasite growth and disease in their offspring.

Zoopharmacognosy can be classified depending on the target of the medication. Some animals lay their eggs in such a way that their offspring are the target of the medication.

Adult monarch butterflies preferentially lay their eggs on toxic plants such as milkweed which reduce parasite growth and disease in their offspring caterpillars.[57] This has been termed transgenerational therapeutic medication.[58]

When detecting endoparasitoid wasps, fruit flies (Drosophila melanogaster) lay their eggs in leaves with high ethanol content as a means of protection for their offspring.[59] These wasps, especially those of the Leptopilina genus, will inject their eggs in approximately 80% of fruit fly larvae.[60] As these wasp eggs develop, they will consume extensively through the larvae. To combat this, the fruit fly larvae will consume a large amount of ethanol from the food source to medicate themselves after wasp infection. Specifically, as the wasps are consuming more of the larvae, they will unknowingly consume more ethanol, which promptly leads to their deaths. This has been termed transgenerational prophylaxis.[58]

Value to humans
Main article: Herbal medicine

In an interview with Neil Campbell, Eloy Rodriguez describes the importance of biodiversity to medicine:

Some of the compounds we've identified by zoopharmacognosy kill parasitic worms, and some of these chemicals may be useful against tumors. There is no question that the templates for most drugs are in the natural world.[29]

Media
  • 2002 British documentary television series Weird Nature episode 6 "Peculiar Potions" documents variety of animals engaging in intoxication or zoopharmacognosy.[61]
  • 2014 documentary Dolphins - Spy in the Pod shows dolphins getting intoxicated on pufferfish.

See also

References
  1. Kapadia M, Zhao H, Ma D, Hatkar R, Marchese M, Sakic B (2014). "Zoopharmacognosy in diseased laboratory mice: conflicting evidence". PLOS ONE. 9 (6): e100684. Bibcode:2014PLoSO...9j0684K. doi:10.1371/journal.pone.0100684. PMC 4067353. PMID 24956477.
  2. Attardo C, Sartori F (2003). "Pharmacologically active plant metabolites as survival strategy products". Bollettino Chimico Farmaceutico. 142 (2): 54–65. PMID 12705091.
  3. Biser JA (1998). "Really wild remedies — medicinal plant use by animals". nationalzoo.si.edu. National Zoological Park. Archived from the original on 2004-06-30. Retrieved 2005-01-13.
  4. Lozano GA (1998). "Parasitic stress and self-medication in wild animals". Stress and Behavior. pp. 291–317. doi:10.1016/s0065-3454(08)60367-8. ISBN 9780120045273. {{cite book}}: |journal= ignored (help)
  5. Raman R, Kandula S (2008). "Zoopharmacognosy: Self-medication in wild animals". Resonance. 13 (3): 245–253. doi:10.1007/s12045-008-0038-5. S2CID 124087315.
  6. Singer MS, Mace KC, Bernays EA (2009). "Self-medication as adaptive plasticity: increased ingestion of plant toxins by parasitized caterpillars". PLOS ONE. 4 (3): e4796. Bibcode:2009PLoSO...4.4796S. doi:10.1371/journal.pone.0004796. PMC 2652102. PMID 19274098.
  7. Rodriguez E, Wrangham R (1993). "Zoopharmacognosy: The Use of Medicinal Plants by Animals". Phytochemical Potential of Tropical Plants. Vol. 27. pp. 89–105. doi:10.1007/978-1-4899-1783-6_4. ISBN 978-1-4899-1785-0.
  8. Cindy E (2002). Wild Health: How Animals Keep Themselves Well and What We Can Learn from Them. Harcourt Mifflin Harcourt, New York.
  9. Fowler A, Koutsioni Y, Sommer V (January 2007). "Leaf-swallowing in Nigerian chimpanzees: evidence for assumed self-medication". Primates; Journal of Primatology. 48 (1): 73–76. doi:10.1007/s10329-006-0001-6. PMID 16897194. S2CID 24862484.
  10. Theara, Gurjit K.; Ruíz Macedo, Juan; Zárate Gómez, Ricardo; Heymann, Eckhard W.; Dolotovskaya, Sofya (2022-05-17). "Fur rubbing in Plecturocebus cupreus – an incidence of self-medication?". Primate Biology. 9 (1): 7–10. doi:10.5194/pb-9-7-2022. ISSN 2363-4707. PMC 9128366. PMID 35620359.
  11. Divekar, Pratap Adinath; Narayana, Srinivasa; Divekar, Bhupendra Adinath; Kumar, Rajeev; Gadratagi, Basana Gowda; Ray, Aishwarya; Singh, Achuit Kumar; Rani, Vijaya; Singh, Vikas; Singh, Akhilesh Kumar; Kumar, Amit; Singh, Rudra Pratap; Meena, Radhe Shyam; Behera, Tusar Kanti (January 2022). "Plant Secondary Metabolites as Defense Tools against Herbivores for Sustainable Crop Protection". International Journal of Molecular Sciences. 23 (5): 2690. doi:10.3390/ijms23052690. ISSN 1422-0067. PMC 8910576. PMID 35269836.
  12. Wink, Michael (2018-04-11). "Plant Secondary Metabolites Modulate Insect Behavior-Steps Toward Addiction?". Frontiers in Physiology. 9: 364. doi:10.3389/fphys.2018.00364. ISSN 1664-042X. PMC 5904355. PMID 29695974.
  13. Huffman, Michael A. (2017-01-28). "Primate Self-Medication, Passive Prevention and Active Treatment - A Brief Review". International Journal of Multidisciplinary Studies. 3 (2): 1. doi:10.4038/ijms.v3i2.1. ISSN 2362-079X.
  14. Clayton DH, Wolfe ND (February 1993). "The adaptive significance of self-medication". Trends in Ecology & Evolution. 8 (2): 60–63. doi:10.1016/0169-5347(93)90160-q. PMID 21236108.
  15. Fruth B, Ikombe NB, Matshimba GK, Metzger S, Muganza DM, Mundry R, Fowler A (February 2014). "New evidence for self-medication in bonobos: Manniophyton fulvum leaf- and stemstrip-swallowing from LuiKotale, Salonga National Park, DR Congo". American Journal of Primatology. 76 (2): 146–158. doi:10.1002/ajp.22217. PMID 24105933. S2CID 20378063.
  16. Garber, P. A.; Kitron, U. (1997-08-01). "Seed Swallowing in Tamarins: Evidence of a Curative Function or Enhanced Foraging Efficiency?". International Journal of Primatology. 18 (4): 523–538. doi:10.1023/A:1026359105653. ISSN 1573-8604. S2CID 21986726.
  17. Huffman, M.A. (2010), "Self-Medication: Passive Prevention and Active Treatment", Encyclopedia of Animal Behavior, Elsevier, pp. 125–131, doi:10.1016/b978-0-08-045337-8.00132-7, ISBN 9780080453378, S2CID 82064086, retrieved 2022-11-14
  18. Diamond JM (July 1999). "Evolutionary biology. Dirty eating for healthy living". Nature. 400 (6740): 120–121. Bibcode:1999Natur.400..120D. doi:10.1038/22014. PMID 10408435. S2CID 4404459.
  19. Bravo, C.; Bautista, L.M.; García-París, M.; Blanco, G.; Alonso, J.C. (2014). "Males of a strongly polygynous species consume more poisonous food than females". PLOS ONE. 9 (10): e111057. doi:10.1371/journal.pone.0111057. PMC 4206510. PMID 25337911.
  20. Sánchez-Barbudo, I. S.; Camarero, P. R.; García-Montijano, M.; Mateo, R. (2012). "Possible cantharidin poisoning of a great bustard (Otis tarda)". Toxicon. 59 (1): 100–103. doi:10.1016/j.toxicon.2011.10.002. PMID 22001622.
  21. Heneberg, P. (2016). "On Otis tarda and Marquis de Sade: what motivates male Great Bustards to consume Blister Beetles (Meloidae)?". Journal of Ornithology. 57 (4): 1123–1125. doi:10.1007/s10336-016-1369-8. S2CID 17325635.
  22. Bautista, L.M.; Bolivar, P.; Gómez-Muñoz, M. T.; Martínez-Díaz, R. A.; Andrés, M. F.; Alonso, J. C.; Bravo, C.; González-Coloma, A. (2022). "Bioactivity of plants eaten by wild birds against laboratory models of parasites and pathogens" (PDF). Frontiers in Ecology and Evolution. 10: 1027201. doi:10.3389/fevo.2022.1027201.
  23. Bos N, Sundström L, Fuchs S, Freitak D (November 2015). "Ants medicate to fight disease". Evolution; International Journal of Organic Evolution. 69 (11): 2979–84. doi:10.1111/evo.12752. PMID 26283006. S2CID 205124251.
  24. Villalba JJ, Miller J, Ungar ED, Landau SY, Glendinning J (2014). "Ruminant self-medication against gastrointestinal nematodes: evidence, mechanism, and origins". Parasite. 21: 31. doi:10.1051/parasite/2014032. PMC 4073621. PMID 24971486.
  25. Villalba, J.J.; Provenza, F.D. (2007). "Self-medication and homeostatic behaviour in herbivores: learning about the benefits of nature's pharmacy". Animal. 1 (9): 1360–1370. doi:10.1017/s1751731107000134. ISSN 1751-7311. PMID 22444892. S2CID 31617157.
  26. Oyeyemi, Ifeoluwa T.; Akinlabi, Akinbiyi A.; Adewumi, Aderiike; Aleshinloye, Abimbola O.; Oyeyemi, Oyetunde T. (March 2018). "Vernonia amygdalina : A folkloric herb with anthelminthic properties". Beni-Suef University Journal of Basic and Applied Sciences. 7 (1): 43–49. doi:10.1016/j.bjbas.2017.07.007. ISSN 2314-8535.
  27. Jacobs JO (2000). "Bonobo's late night tales". Retrieved November 27, 2013.
  28. Costa-Neto EM (2012). "Zoopharmacognosy, the self-medication behavior of animals". Interfaces Científicas-Saúde e Ambiente. 1 (1): 61–72. doi:10.17564/2316-3798.2012v1n1p61-72.
  29. Campbell NA (1996). An interview with Eloy Rodriguez. Biology (4th edition). Benjamin Cummings, NY. p. 23. ISBN 978-0-8053-1957-6.
  30. Raman R, Kandula S (2008). "Zoopharmacognosy: self-medication in wild animals". Resonance. 13 (3): 245–253. doi:10.1007/s12045-008-0038-5. S2CID 124087315.
  31. Linden E (2002). The Octopus and the Orangutan: More Tales of Animal Intrigue, Intelligence and Ingenuity. New York City: Plume. pp. 16–17, 104–105, 191. ISBN 978-0-452-28411-1. OCLC 49627740.
  32. Huffman MA (1997). "Current evidence for self-medication in primates: a multidisciplinary perspective" (PDF). Yearbook of Physical Anthropology. 40 (S25): 171–200. doi:10.1002/(SICI)1096-8644(1997)25+<171::AID-AJPA7>3.0.CO;2-7. S2CID 45781137.
  33. Orzeck R (2007). "Pondering the mysteries of our universe: Why do dogs eat grass?". Retrieved October 28, 2013.
  34. Glander KE (1994). "Nonhuman primate self-medication with wild plant foods" (PDF). In Etkin NL (ed.). Eating on the Wild Side: The Pharmacologic, Ecologic, and Social Implications of Using Noncultigens. The University of Arizona Press. pp. 227–239.
  35. Villalba JJ, Provenza FD, Shaw R (2006). "Sheep self-medicate when challenged with illness-inducing foods". Animal Behaviour. 71 (5): 1131–1139. doi:10.1016/j.anbehav.2005.09.012. S2CID 53178715.
  36. Sherwin CM, Olsson IA (2004). "Housing conditions affect self-administration of anxiolytic by laboratory mice". Animal Welfare. 13: 33–38.
  37. Viviano, Andrea; Huffman, Michael A.; Senini, Caterina; Mori, Emiliano (2022-10-14). "Do porcupines self-medicate? The seasonal consumption of plants with antiparasitic properties coincides with that of parasite infections in Hystrix cristata of Central Italy". European Journal of Wildlife Research. 68 (6). doi:10.1007/s10344-022-01620-8. ISSN 1612-4642. S2CID 252879139.
  38. Jain CP, Dashora A, Garg R, Kataria U, Vashistha B (2008). "Animal self-medication through natural sources" (PDF). Natural Product Radiance. 7 (1): 49–53.
  39. Krishnamani R, Mahaney WC (May 2000). "Geophagy among primates: adaptive significance and ecological consequences". Animal Behaviour. 59 (5): 899–915. doi:10.1006/anbe.1999.1376. PMID 10860518. S2CID 43702331.
  40. Bolton KA, Campbell VM, Burton FD (1998). "Chemical analysis of soil of Kowloon (Hong Kong) eaten by hybrid macaques". Journal of Chemical Ecology. 24 (2): 195–205. doi:10.1023/a:1022521306597. S2CID 12576232.
  41. Westergaard G, Fragaszy D (1987). "Self-treatment of wounds by a capuchin monkey (Cebus apella)". Human Evolution. 2 (6): 557–56. doi:10.1007/bf02437429. S2CID 84199315.
  42. Ritchie BG, Fragaszy DM (1988). "Capuchin monkey (Cebus apella) grooms her infant's wound with tools". American Journal of Primatology. 16 (4): 345–348. doi:10.1002/ajp.1350160407. PMID 32079370. S2CID 83507723. Archived from the original on 2013-01-05.
  43. Cowen R (November 1990). "Medicine on the wild side; animals may rely on a natural pharmacy". Science News.
  44. Terrell B, Fennell A (June 2009). "Oshá (bear root) Ligusticum porteri JM Coult. & Rose var. porteri". Native Plants Journal. 10 (2): 110–118. doi:10.2979/NPJ.2009.10.2.110. S2CID 85289045.
  45. Weldon PJ, Aldrich JR, Klun JA, Oliver JE, Debboun M (July 2003). "Benzoquinones from millipedes deter mosquitoes and elicit self-anointing in capuchin monkeys (Cebus spp.)". Die Naturwissenschaften. 90 (7): 301–304. Bibcode:2003NW.....90..301W. doi:10.1007/s00114-003-0427-2. PMID 12883771. S2CID 15161505.
  46. Valderrama X, Robinson JG, Attygalle AB, Eisner T (2000). "Seasonal anointment with millipedes in a wild primate: a chemical defense against insects?". Journal of Chemical Ecology. 26 (12): 2781–2790. doi:10.1023/A:1026489826714. S2CID 25147071.
  47. Laska M, Bauer V, Salazar LT (April 2007). "Self-anointing behavior in free-ranging spider monkeys (Ateles geoffroyi) in Mexico". Primates; Journal of Primatology. 48 (2): 160–163. doi:10.1007/s10329-006-0019-9. PMID 17103123. S2CID 19156708.
  48. Banerji, Urvija. "Lemurs Get High on Their Millipede Supply". Atlas Obscura. Retrieved 22 March 2023.
  49. Downer, John (April 25, 2002). "Peculiar Potions: Narcotic insecticide". Weird Nature. Series 1. Episode 4. John Downer Productions. BBC Four. Retrieved March 22, 2023.
  50. Falótico T, Labruna MB, Verderane MP, De Resende BD, Izar P, Ottoni EB (July 2007). "Repellent efficacy of formic acid and the abdominal secretion of carpenter ants (Hymenoptera: Formicidae) against Amblyomma ticks (Acari: Ixodidae)". Journal of Medical Entomology. 44 (4): 718–721. doi:10.1093/jmedent/44.4.718. PMID 17695031.
  51. Huashuayo-Llamocca, Rosario; Heymann, Eckhard W. (2017). "Fur-rubbing with Piper leaves in the San Martín titi monkey, Callicebus oenanthe". Primate Biology. 4 (1): 127–130. doi:10.5194/pb-4-127-2017. ISSN 2363-4715. PMC 7041530. PMID 32110700.
  52. Clark L, Russell Mason J (November 1988). "Effect of biologically active plants used as netst material and the derived benefit to starling nestlings". Oecologia. 77 (2): 174–180. Bibcode:1988Oecol..77..174C. doi:10.1007/bf00379183. PMID 28310369. S2CID 8803833.
  53. Ichida J (2004-05-26). "Birds use herbs to protect their nests, BJS, Science Blog, Wed, 2004-05-26". Proceedings of the 104th General Meeting of the American Society for Microbiology.
  54. Christe P, Oppliger A, Bancala F, Castella G, Chapuisat M (2003). "Evidence for collective medication in ants". Ecology Letters. 6: 19–22. doi:10.1046/j.1461-0248.2003.00395.x.
  55. Castella G, Chapuisat M, Christe P (2008). "Prophylaxis with resin in wood ants". Animal Behaviour. 75 (4): 1591–1596. doi:10.1016/j.anbehav.2007.10.014. S2CID 39047801.
  56. Simone-Finstrom MD, Spivak M (2012). "Increased resin collection after parasite challenge: a case of self-medication in honey bees?". PLOS ONE. 7 (3): e34601. Bibcode:2012PLoSO...734601S. doi:10.1371/journal.pone.0034601. PMC 3315539. PMID 22479650.
  57. Lefèvre T, Oliver L, Hunter MD, De Roode JC (December 2010). "Evidence for trans-generational medication in nature". Ecology Letters. 13 (12): 1485–1493. doi:10.1111/j.1461-0248.2010.01537.x. hdl:2027.42/79381. PMID 21040353.
  58. de Roode JC, Lefèvre T, Hunter MD (April 2013). "Ecology. Self-medication in animals". Science. 340 (6129): 150–151. Bibcode:2013Sci...340..150D. doi:10.1126/science.1235824. PMID 23580516. S2CID 32837400.
  59. Milan, Neil F.; Kacsoh, Balint Z.; Schlenke, Todd A. (March 2012). "Alcohol Consumption as Self-Medication against Blood-Borne Parasites in the Fruit Fly". Current Biology. 22 (6): 488–493. doi:10.1016/j.cub.2012.01.045. PMC 3311762. PMID 22342747.
  60. Meadows, Robin (2015-12-16). "Odors Help Fruit Flies Escape Parasitoid Wasps". PLOS Biology. 13 (12): e1002317. doi:10.1371/journal.pbio.1002317. ISSN 1545-7885. PMC 4682656. PMID 26674328.
  61. "Peculiar Potions part 1 / 3". BBC Weird Nature – via YouTube.

Further reading
  • Samorini, Giorgio (2002) Animals and Psychedelics: The Natural World And The Instinct To Alter Consciousness
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