16BO133

16BO133 is a SARS-like coronavirus (SL-COV) which was found in the greater horseshoe bat in South Korea. It was published in 2019 and its genome was completely sequenced. The sequenced Korean SARSr-CoV strain belongs to the severe acute respiratory syndrome coronavirus 1, and its genome sequence similarity is 82.8%.

16BO133
Virus classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Pisuviricota
Class: Pisoniviricetes
Order: Nidovirales
Family: Coronaviridae
Genus: Betacoronavirus
Subgenus: Sarbecovirus
Species:
SARS-related coronavirus
Strain:
16BO133

Discovery

The 16BO133 virus was discovered in the oral cavity of the greater horseshoe bat in 2016. The genome of this virus strain is 29075 nt. Among SARSr-CoVs, 16BO133 is the closest to the JTMC15 virus, which was published in 2016 and discovered in Jilin, China, with a genome nucleic acid sequence similarity of 98.3%. Compared with other SARSr-CoVs, these two viruses have the ORF8 strain due to a frameshift mutation at the end of ORF7b.[1][2] The similarity of the genome nucleic acid sequence of 16BO133 virus and SARS-CoV is 82.8%.[3]

Although other SARSr-CoV strains have been found in Korea in the past (B15-21 virus, etc.), none of them have been sequenced.[4] The 16BO133 virus is the first Korean SARSr-CoV strain to be completely sequenced.[1]

Phylogenetic

A phylogenetic tree based on whole-genome sequences of SARS-CoV-1 and related coronaviruses is:

SARS‑CoV‑1 related coronavirus
 
 
 
 

16BO133, 86.3% to SARS-CoV-1, Rhinolophus ferrumequinum, North Jeolla, South Korea[5]

 
 

JTMC15, 86.4% to SARS-CoV-1, Rhinolophus ferrumequinum, Tonghua, Jilin[6]

 
 
 

Bat SARS CoV Rf1, 87.8% to SARS-CoV-1, Rhinolophus ferrumequinum, Yichang, Hubei[7]

 
 
 
 

BtCoV HKU3, 87.9% to SARS-CoV-1, Rhinolophus sinicus, Hong Kong and Guangdong[8]

 
 
 
 

LYRa11, 90.9% to SARS-CoV-1, Rhinolophus affinis, Baoshan, Yunnan[9]

 
 
 

Bat SARS-CoV/Rp3, 92.6% to SARS-CoV-1, Rhinolophus pearsoni, Nanning, Guangxi[7]

 
 
 

Bat SL-CoV YNLF_31C, 93.5% to SARS-CoV-1, Rhinolophus ferrumequinum, Lufeng, Yunnan[10]

 
 

Bat SL-CoV YNLF_34C, 93.5% to SARS-CoV-1, Rhinolophus ferrumequinum, Lufeng, Yunnan[10]

 
 
 
 
 
 

SHC014-CoV, 95.4% to SARS-CoV-1, Rhinolophus sinicus, Kunming, Yunnan[11]

 
 

WIV1, 95.6% to SARS-CoV-1, Rhinolophus sinicus, Kunming, Yunnan[11]

 
 
 

WIV16, 96.0% to SARS-CoV-1, Rhinolophus sinicus Kunming, Yunnan[12]

 
 
 
 

Civet SARS-CoV, 99.8% to SARS-CoV-1, Paguma larvata, market in Guangdong, China[8]

 
 

SARS-CoV-1

 
 
 
 
 
 
 
 

SARS-CoV-2, 79% to SARS-CoV-1[13]

 

See also
  • Bat coronavirus RaTG13

References
  1. Kim Y, Son K, Kim YS, Lee SY, Jheong W, Oem JK (2019). "Complete genome analysis of a SARS-like bat coronavirus identified in the Republic of Korea". Virus Genes. 55 (4): 545–549. doi:10.1007/s11262-019-01668-w. PMC 7089380. PMID 31076983.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. Xu L, Zhang F, Yang W, Jiang T, Lu G, He B; et al. (2016). "Detection and characterization of diverse alpha- and betacoronaviruses from bats in China". Virol Sin. 31 (1): 69–77. doi:10.1007/s12250-016-3727-3. PMC 7090707. PMID 26847648.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  3. Na EJ, Lee SY, Kim HJ, Oem JK (2021). "Comparative genetic analyses of Korean bat coronaviruses with SARS-CoV and the newly emerged SARS-CoV-2". J Vet Sci. 22 (1): e12. doi:10.4142/jvs.2021.22.e12. PMC 7850784. PMID 33522164.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  4. Kim HK, Yoon SW, Kim DJ, Koo BS, Noh JY, Kim JH; et al. (2016). "Detection of Severe Acute Respiratory Syndrome-Like, Middle East Respiratory Syndrome-Like Bat Coronaviruses and Group H Rotavirus in Faeces of Korean Bats". Transbound Emerg Dis. 63 (4): 365–72. doi:10.1111/tbed.12515. PMC 7169817. PMID 27213718.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  5. Kim, Yongkwan; Son, Kidong; Kim, Young-Sik; Lee, Sook-Young; Jheong, Weonhwa; Oem, Jae-Ku (2019). "Complete genome analysis of a SARS-like bat coronavirus identified in the Republic of Korea". Virus Genes. 55 (4): 545–549. doi:10.1007/s11262-019-01668-w. PMC 7089380. PMID 31076983.
  6. Xu, L; Zhang, F; Yang, W; Jiang, T; Lu, G; He, B; Li, X; Hu, T; Chen, G; Feng, Y; Zhang, Y; Fan, Q; Feng, J; Zhang, H; Tu, C (February 2016). "Detection and characterization of diverse alpha- and betacoronaviruses from bats in China". Virologica Sinica. 31 (1): 69–77. doi:10.1007/s12250-016-3727-3. PMC 7090707. PMID 26847648.
  7. Li, W. (2005). "Bats Are Natural Reservoirs of SARS-Like Coronaviruses". Science. 310 (5748): 676–679. Bibcode:2005Sci...310..676L. doi:10.1126/science.1118391. ISSN 0036-8075. PMID 16195424. S2CID 2971923.
  8. Xing‐Yi Ge, Ben Hu, and Zheng‐Li Shi (2015). "BAT CORONAVIRUSES". In Lin-Fa Wang and Christopher Cowled (ed.). Bats and Viruses: A New Frontier of Emerging Infectious Diseases (First ed.). John Wiley & Sons. pp. 127–155. doi:10.1002/9781118818824.ch5.{{cite book}}: CS1 maint: multiple names: authors list (link)
  9. He, Biao; Zhang, Yuzhen; Xu, Lin; Yang, Weihong; Yang, Fanli; Feng, Yun; et al. (2014). "Identification of diverse alphacoronaviruses and genomic characterization of a novel severe acute respiratory syndrome-like coronavirus from bats in China". J Virol. 88 (12): 7070–82. doi:10.1128/JVI.00631-14. PMC 4054348. PMID 24719429.
  10. Lau, Susanna K. P.; Feng, Yun; Chen, Honglin; Luk, Hayes K. H.; Yang, Wei-Hong; Li, Kenneth S. M.; Zhang, Yu-Zhen; Huang, Yi; et al. (2015). "Severe Acute Respiratory Syndrome (SARS) Coronavirus ORF8 Protein Is Acquired from SARS-Related Coronavirus from Greater Horseshoe Bats through Recombination". Journal of Virology. 89 (20): 10532–10547. doi:10.1128/JVI.01048-15. ISSN 0022-538X. PMC 4580176. PMID 26269185.
  11. Xing-Yi Ge; Jia-Lu Li; Xing-Lou Yang; et al. (2013). "Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor". Nature. 503 (7477): 535–8. Bibcode:2013Natur.503..535G. doi:10.1038/nature12711. PMC 5389864. PMID 24172901.
  12. Yang, Xing-Lou; Hu, Ben; Wang, Bo; Wang, Mei-Niang; Zhang, Qian; Zhang, Wei; et al. (2016). "Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus". Journal of Virology. 90 (6): 3253–6. doi:10.1128/JVI.02582-15. PMC 4810638. PMID 26719272.
  13. Ben, Hu; Hua, Guo; Peng, Zhou; Zheng-Li, Shi (2020). "Characteristics of SARS-CoV-2 and COVID-19". Nature Reviews Microbiology. 19 (3): 141–154. doi:10.1038/s41579-020-00459-7. PMC 7537588. PMID 33024307.

References
  • Data related to 16BO133 at Wikispecies
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