ASP-7663
ASP-7663 is a chemical compound which acts as a potent, selective activator of the TRPA1 channel. It has protective effects on cardiac tissue, and is used for research into the function of the TRPA1 receptor.[1][2]
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Preferred IUPAC name
(E)-[7-Fluoro-1-(2-methylpropyl)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]acetic acid | |
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C14H14FNO3 |
Molar mass | 263.268 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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See also
References
- Pan Y, Zhao G, Cai Z, Chen F, Xu D, Huang S, et al. (2016). "Synergistic Effect of Ferulic Acid and Z-Ligustilide, Major Components of A. sinensis, on Regulating Cold-Sensing Protein TRPM8 and TPRA1 In Vitro". Evidence-Based Complementary and Alternative Medicine. 2016: 3160247. doi:10.1155/2016/3160247. PMC 4931054. PMID 27413384. S2CID 14007898.
- Lu Y, Piplani H, McAllister SL, Hurt CM, Gross ER (December 2016). "Transient Receptor Potential Ankyrin 1 Activation within the Cardiac Myocyte Limits Ischemia-reperfusion Injury in Rodents". Anesthesiology. 125 (6): 1171–1180. doi:10.1097/ALN.0000000000001377. PMC 5110384. PMID 27748654.
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