Accelerated phase chronic myelogenous leukemia

Accelerated phase chronic myelogenous leukemia is a phase of chronic myelogenous leukemia in which the disease is progressing.[1] In this phase, 10 to 19% of the cells in the blood and bone marrow are blast cells (immature blood cells). In the accelerated phase, these leukemia cells grow quickly.

Aman vibhore
SpecialtyHematology and oncology

Symptoms

Common symptoms include fever, bone pain, and swollen spleen.[2]

Treatment

Patients treated with imatinib, dasatinib, and nilotinib have shown meaningful rates of hematologic and cytogenetic response.[3]

Prognosis

Prognosis is very poor once chronic myelogenous leukemia reaches the accelerated phase; it behaves similarly to acute myeloid leukemia.

References
  1. Moshe Talpaz (2002). "Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study". Blood. 99 (6): 1928–1937. doi:10.1182/blood.v99.6.1928. PMID 11877262. S2CID 29480569.
  2. "Chronic myelogenous leukemia (CML)".
  3. Shah, NP (Mar 2008). "Advanced CML: therapeutic options for patients in accelerated and blast phases". Journal of the National Comprehensive Cancer Network. 6 Suppl 2: S31–S36. PMID 18397679.
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