Biological agent

A biological agent (also called bio-agent, biological threat agent, biological warfare agent, biological weapon, or bioweapon) is a bacterium, virus, protozoan, parasite, fungus, or toxin that can be used purposefully as a weapon in bioterrorism or biological warfare (BW).[1] In addition to these living or replicating pathogens, toxins and biotoxins are also included among the bio-agents. More than 1,200 different kinds of potentially weaponizable bio-agents have been described and studied to date.

This article is about harmful biological agents. For therapeutic biological drugs, see Biopharmaceutical.
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A culture of Bacillus anthracis, the causative agent of anthrax

Biological agents have the ability to adversely affect human health in a variety of ways, ranging from relatively mild allergic reactions to serious medical conditions, including serious injury, as well as serious or permanent disability or even death. Many of these organisms are ubiquitous in the natural environment where they are found in water, soil, plants, or animals.[1] Bio-agents may be amenable to "weaponization" to render them easier to deploy or disseminate. Genetic modification may enhance their incapacitating or lethal properties, or render them impervious to conventional treatments or preventives. Since many bio-agents reproduce rapidly and require minimal resources for propagation, they are also a potential danger in a wide variety of occupational settings.[1]

The 1972 Biological Weapons Convention (BWC) is an international treaty banning the development, use or stockpiling of biological weapons; as of March 2021, there were 183 States Parties to the BWC.[2] Bio-agents are, however, widely studied for both defensive and medical research purposes under various biosafety levels and within biocontainment facilities throughout the world.

Classifications

Operational

The former US biological warfare program (1943–1969) categorized its weaponized anti-personnel bio-agents as either "lethal agents" (Bacillus anthracis, Francisella tularensis, Botulinum toxin) or "incapacitating agents" (Brucella suis, Coxiella burnetii, Venezuelan equine encephalitis virus, Staphylococcal enterotoxin B).[3]

Since 1997, United States law has declared a list of bio-agents designated by the U.S. Department of Health and Human Services or the U.S. Department of Agriculture that have the "potential to pose a severe threat to public health and safety" to be officially defined as "select agents" and possession or transportation of them are tightly controlled as such.[4] Select agents are divided into "HHS select agents and toxins", "USDA select agents and toxins" and "Overlap select agents and toxins".

Regulatory

The U.S. Centers for Disease Control and Prevention (CDC) breaks biological agents into three categories: Category A, Category B, and Category C. Category A agents pose the greatest threat to the U.S. Criteria for being a Category "A" agent include high rates of morbidity and mortality; ease of dissemination and communicability; ability to cause a public panic; and special action required by public health officials to respond. Category A agents include anthrax, botulism, plague, smallpox, and viral hemorrhagic fevers.

List of bio-agents of military importance
The following pathogens and toxins were weaponized by one nation or another at some time. NATO abbreviations are included where applicable.

Bacterial bio-agents
Disease Causative Agent (Military Symbol)
Anthrax Bacillus anthracis (N or TR)
Brucellosis (bovine) Brucella abortus
Brucellosis (caprine) Brucella melitensis (AM or BX)
Brucellosis (porcine) Brucella suis (US, AB or NX)
Cholera Vibrio cholerae (HO)
Diphtheria Corynebacterium diphtheriae (DK)
Dysentery (bacterial) Shigella dysenteriae, Escherichia coli (Y)
Glanders Burkholderia mallei (LA)
Listeriosis Listeria monocytogenes (TQ)
Melioidosis Burkholderia pseudomallei (HI)
Plague Yersinia pestis (LE)
Tularemia Francisella tularensis (SR or JT)

Chlamydial bio-agents
Disease Causative Agent (Military Symbol)
Psittacosis Chlamydophila psittaci (SI)

Rickettsial bio-agents
Disease Causative Agent (Military Symbol)
Q Fever Coxiella burnetii (OU)
Rocky Mountain spotted fever Rickettsia rickettsii (RI or UY)
Typhus (human) Rickettsia prowazekii (YE)
Typhus (murine) Rickettsia typhi (AV)

Viral bio-agents
Disease Causative Agent (Military Symbol) Comments
Equine Encephalitis (Eastern) Eastern equine encephalitis virus (ZX)
Equine Encephalitis (Venezuelan) Venezuelan Equine Encephalomyelitis virus (FX)
Equine Encephalitis (Western) Western equine encephalitis virus (EV)
Japanese B encephalitis Japanese encephalitis virus (AN)
Marburg Hemorrhagic Fever (Marburg HF) Marburg Virus (MARV) by the Soviet Union[5]
Rift Valley fever Rift Valley fever virus (FA)
Smallpox Variola virus (ZL)
Yellow fever Yellow fever virus (OJ or LU)

Mycotic bio-agents
Disease Causative Agent (Military Symbol)
Coccidiomycosis Coccidioides immitis (OC)

Biological toxins
Toxin Source of Toxin (Military Symbol)
Abrin Rosary pea (Abrus precatorius)
Botulinum toxins (A through G) Clostridium botulinum bacteria or spores, and several other Clostridial species. (X or XR)
Ricin Castor bean (Ricinus communis) (W or WA)
Saxitoxin Various marine and brackish cyanobacteria, such as Anabaena, Aphanizomenon, Lyngbya, and Cylindrospermopsis (TZ)
Staphyloccocal enterotoxin B Staphylococcus aureus (UC or PG)
Tetrodotoxin Various marine bacteria, including Vibrio alginolyticus, Pseudoalteromonas tetraodonis (PP)
Trichothecene mycotoxins Various species of fungi, including Fusarium, Trichoderma, and Stachybotrys

Biological vectors
Vector (Military Symbol) Disease
Mosquito (Aedes aegypti) (AP) Malaria, Dengue fever, Chikungunya, Yellow fever, other Arboviruses
Oriental flea (Xenopsylla cheopis) Plague, Murine typhus

Simulants

Simulants are organisms or substances which mimic physical or biological properties of real biological agents, without being pathogenic. They are used to study the efficiency of various dissemination techniques or the risks caused by the use of biological agents in bioterrorism.[6] To simulate dispersal, attachment or the penetration depth in human or animal lungs, simulants must have particle sizes, specific weight and surface properties, similar to the simulated biological agent.

The typical size of simulants (1–5 µm) enables it to enter buildings with closed windows and doors and penetrate deep into the lungs. This bears a significant health risk, even if the biological agent is normally not pathogenic.

International law
The Biological Weapons Convention[7]

While the history of biological weapons use goes back more than six centuries to the siege of Caffa in 1346,[8] international restrictions on biological weapons began only with the 1925 Geneva Protocol, which prohibits the use but not the possession or development of chemical and biological weapons.[9] Upon ratification of the Geneva Protocol, several countries made reservations regarding its applicability and use in retaliation.[10] Due to these reservations, it was in practice a "no-first-use" agreement only.[11]

The 1972 Biological Weapons Convention (BWC) supplements the Geneva Protocol by prohibiting the development, production, acquisition, transfer, stockpiling and use of biological weapons.[12] Having entered into force on 26 March 1975, the BWC was the first multilateral disarmament treaty to ban the production of an entire category of weapons of mass destruction.[12] As of March 2021, 183 states have become party to the treaty.[2] The BWC is considered to have established a strong global norm against biological weapons,[13] which is reflected in the treaty's preamble, stating that the use of biological weapons would be "repugnant to the conscience of mankind".[14] However, the BWC's effectiveness has been limited due to insufficient institutional support and the absence of any formal verification regime to monitor compliance.[15]

In 1985, the Australia Group was established, a multilateral export control regime of 43 countries aiming to prevent the proliferation of chemical and biological weapons.[16]

In 2004, the United Nations Security Council passed Resolution 1540, which obligates all UN Member States to develop and enforce appropriate legal and regulatory measures against the proliferation of chemical, biological, radiological, and nuclear weapons and their means of delivery, in particular, to prevent the spread of weapons of mass destruction to non-state actors.[17]

See also

References
  1. "Biological Agents". United States Department of Labor: OSHA. Retrieved 2012-05-31.
  2. "Disarmament Treaties Database: Biological Weapons Convention". United Nations Office for Disarmament Affairs. Archived from the original on 2013-03-03. Retrieved 2021-03-02.
  3. Headquarters, Departments of the Army, the Navy, and the Air Force, and Commandant, Marine Corps (17 July 2000), Field Manual: Treatment of Biological Warfare Casualties (Army FM 8-284/Navy NAVMED P-5042/Air Force AFMAN (I) 44-156/Marine Corps MCRP 4-11.1C), para 1-4 (pg 1-3).
  4. Additional Requirements for Facilities Transferring or Receiving Select Agents, Title 42 CFR Part 72 and Appendix A; 15 April 1997 (DHHS).
  5. Kenneth Alibek and S. Handelman. Biohazard: The Chilling True Story of the Largest Covert Biological Weapons Program in the World - Told from Inside by the Man Who Ran it. 1999. Delta (2000) ISBN 0-385-33496-6.
  6. "Biological Warfare (BW) Simulants – Bacillus globigii (BG)". The Night Ferry. 2010-02-05. Retrieved 2017-04-03.
  7. United Nations (1972). Biological Weapons Convention.
  8. Wheelis, Mark (September 2002). "Biological Warfare at the 1346 Siege of Caffa". Emerging Infectious Diseases. 8 (9): 971–975. doi:10.3201/eid0809.010536. PMC 2732530. PMID 12194776.
  9. "Text of the 1925 Geneva Protocol". United Nations Office for Disarmament Affairs. Archived from the original on 2015-04-08. Retrieved 2021-03-02.
  10. "Disarmament Treaties Database: 1925 Geneva Protocol". United Nations Office for Disarmament Affairs. Archived from the original on 2013-08-25. Retrieved 2021-03-02.
  11. Beard, Jack M. (April 2007). "The Shortcomings of Indeterminacy in Arms Control Regimes: The Case of the Biological Weapons Convention". American Journal of International Law. 101 (2): 277. doi:10.1017/S0002930000030098. ISSN 0002-9300. S2CID 8354600.
  12. "Biological Weapons Convention". United Nations Office for Disarmament Affairs. Archived from the original on 2021-02-15. Retrieved 2021-03-02.
  13. Cross, Glenn; Klotz, Lynn (2020-07-03). "Twenty-first century perspectives on the Biological Weapon Convention: Continued relevance or toothless paper tiger". Bulletin of the Atomic Scientists. 76 (4): 185–191. Bibcode:2020BuAtS..76d.185C. doi:10.1080/00963402.2020.1778365. ISSN 0096-3402.
  14. "Preamble, Biological Weapons Convention". United Nations Office for Disarmament Affairs. Archived from the original on 2014-03-06. Retrieved 2021-03-02.
  15. Dando, Malcolm (2006). Chapter 9: The Failure of Arms Control, In Bioterror and Biowarfare: A Beginner's Guide. Oneworld. pp. 146–165. ISBN 9781851684472.
  16. "The Origins of the Australia Group". Australian Department of Foreign Affairs and Trade. Archived from the original on 2021-03-02. Retrieved 2021-03-02.
  17. "1540 Committee". United Nations. Archived from the original on 2021-03-02. Retrieved 2021-03-02.
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