Bipolar neuron

A bipolar neuron, or bipolar cell, is a type of neuron that has two extensions (one axon and one dendrite). Many bipolar cells are specialized sensory neurons for the transmission of sense. As such, they are part of the sensory pathways for smell, sight, taste, hearing, touch, balance and proprioception. The other shape classifications of neurons include unipolar, pseudounipolar and multipolar. During embryonic development, pseudounipolar neurons begin as bipolar in shape but become pseudounipolar as they mature.[1]

Bipolar neuron
Bipolar nerve cell from the spinal ganglion of the pike.
Details
Identifiers
Latinneuron bipolare
THH2.00.06.1.00050
FMA67282
Anatomical terms of neuroanatomy

Common examples are the retina bipolar cell, the ganglia of the vestibulocochlear nerve,[2] the extensive use of bipolar cells to transmit efferent (motor) signals to control muscles, olfactory receptor neurons in the olfactory epithelium for smell (axons form the olfactory nerve), and neurons in the spiral ganglion for hearing (CN VIII).

In the retina
Main article: Retina bipolar cell

Often found in the retina, bipolar cells are crucial as they serve as both direct and indirect cell pathways. The specific location of the bipolar cells allow them to facilitate the passage of signals from where they start in the receptors to where they arrive at the amacrine and ganglion cells. Bipolar cells in the retina are also unusual in that they do not fire impulses like the other cells found within the nervous system. Rather, they pass the information by graded signal changes. Bipolar cells come in two varieties, having either an on-center or an off-center receptive field, each with a surround of the opposite sign. The off-center bipolar cells have excitatory synaptic connections with the photoreceptors, which fire continuously in the dark and are hyperpolarized (suppressed) by light. The excitatory synapses thus convey a suppressive signal to the off-center bipolar cells. On-center bipolar cells have inhibitory synapses with the photoreceptors and therefore are excited by light and suppressed in the dark.[3]

In the vestibular nerve

Bipolar neurons exist within the vestibular nerve as it is responsible for special sensory sensations including hearing, equilibrium and motion detection. The majority of the bipolar neurons belonging to the vestibular nerve exist within the vestibular ganglion with axons extending into the maculae of utricle and saccule as well as into the ampullae of the semicircular canals.[4]

In the spinal ganglia

Bipolar cells are also found in the spinal ganglia, when the cells are in an embryonic condition.

Sometimes the extensions, also called processes, come off from opposite poles of the cell, and the cell then assumes a spindle shape.

In some cases where two fibers are apparently connected with a cell, one of the fibers is really derived from an adjoining nerve cell and is passing to end in a ramification around the ganglion cell, or, again, it may be coiled helically around the nerve process which is issuing from the cell.

In the cerebral cortex

Von Economo neurons, also known as spindle neurons, found in a few select parts of the cerebral cortex of apes and some other intelligent animals, possess a single axon and dendrite and as such have been described as bipolar.[5][6]

Additional images
  • Retinal Bipolar Cell

References
  1. Vanderah, Todd W. (2015). Nolte's The Human Brain : An Introduction to Its Functional Anatomy. Gould, Douglas J., Nolte, John. (7th ed.). Philadelphia, PA. ISBN 9781455728596. OCLC 895731173.
  2. Bipolar+cell Archived 2016-04-03 at the Wayback Machine at eMedicine Dictionary
  3. "David Hubel's Eye, Brain and, Vision". Archived from the original on 2018-07-20. Retrieved 2014-05-06.
  4. Clinically Oriented Anatomy
  5. Allman, John M.; Tetreault, Nicole A.; Hakeem, Atiya Y.; Manaye, Kebreten F.; Semendeferi, Katerina; Erwin, Joseph M.; Park, Soyoung; Goubert, Virginie; Hof, Patrick R. (April 2011). "The von Economo neurons in fronto-insular and anterior cingulate cortex". Annals of the New York Academy of Sciences. 1225 (1): 59–71. Bibcode:2011NYASA1225...59A. doi:10.1111/j.1749-6632.2011.06011.x. ISSN 0077-8923. PMC 3140770. PMID 21534993.
  6. Cauda, Franco; Geminiani, Giuliano Carlo; Vercelli, Alessandro (2014). "Evolutionary appearance of von Economo's neurons in the mammalian cerebral cortex". Frontiers in Human Neuroscience. 8: 104. doi:10.3389/fnhum.2014.00104. ISSN 1662-5161. PMC 3953677. PMID 24672457.

This article incorporates text in the public domain from page 722 of the 20th edition of Gray's Anatomy (1918)



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