Commissural fiber

The corpus callosum is the largest commissural tract in the human brain. It consists of about 200-300 million axons that connect the two cerebral hemispheres. The corpus callosum is essential to the communication between the two hemispheres.[2]

A recent study of individuals with agenesis of the corpus callosum suggests that the corpus callosum plays a vital role in problem solving strategies, verbal processing speed, and executive performance. Specifically, the absence of a fully developed corpus callosum is shown to have a significant relationship with impaired verbal processing speed and problem solving.[3]

Another study of individuals with multiple sclerosis provides evidence that structural and microstructural abnormalities of the corpus callosum are related to cognitive dysfunction. Particularly, verbal and visual memory, information processing speed, and executive tasks were shown to be impaired when compared to healthy individuals. Physical disabilities in multiple sclerosis patients also seem to be related to abnormalities of the corpus callosum, but not to the same extent of other cognitive functions.[4]

Using diffusion tensor imaging, researchers have been able to produce a visualization of this network of fibers, which shows the corpus callosum has an anteroposterior topographical organization that is uniform with the cerebral cortex.

The anterior commissure (also known as the precommissure) is a tract that connects the two temporal lobes of the cerebral hemispheres across the midline, and placed in front of the columns of the fornix. The great majority of fibers connecting the two hemispheres travel through the corpus callosum, which is over 10 times larger than the anterior commissure, and other routes of communication pass through the hippocampal commissure or, indirectly, via subcortical connections. Nevertheless, the anterior commissure is a significant pathway that can be clearly distinguished in the brains of all mammals.

Using diffusion tensor imaging, researchers were able to approximate the location of the anterior commissure where it crosses the midline of the brain. This tract can be observed to be in the shape of a bicycle as it branches through various areas of the brain. Through diffusion tensor imaging results, the anterior commissure was categorized into two fiber systems: 1) the olfactory fibers and 2) the non-olfactory fibers.[5]

The posterior commissure (also known as the epithalamic commissure) is a rounded nerve tract crossing the middle line on the dorsal aspect of the upper end of the cerebral aqueduct. It is important in the bilateral pupillary light reflex.

Evidence suggests the posterior commissure is a tract that plays a role in language processing between the right and left hemispheres of the brain. It connects the pretectal nuclei. A case study described recently in The Irish Medical Journal discussed the role the posterior commissure plays in the connection between the right occipital cortex and the language centers in the left hemisphere. This study explains how visual information from the left side of the visual field is received by the right visual cortex and then transferred to the word form system in the left hemisphere though the posterior commissure and the splenium. Disruption of the posterior commissure can cause alexia without agraphia. It is evident from this case study of alexia without agraphia that the posterior commissure plays a vital role in transferring information from the right occipital cortex to the language centers of the left hemisphere.[6]

The lyra or hippocampal commissure.