Bisdisulizole disodium

Bisdisulizole disodium (INN[1]/USAN,[2] trade name Neo Heliopan AP, INCI disodium phenyl dibenzimidazole tetrasulfonate) is a water-soluble organic compound which is added to sunscreens to absorb UVA rays. It is marketed by Symrise.

Bisdisulizole disodium
Names
Preferred IUPAC name
Disodium 2,2′-(1,4-phenylene)bis(6-sulfo-1H-1,3-benzimidazole-4-sulfonate)
Identifiers
CAS Number
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.121.951
PubChem CID
UNII
InChI
  • InChI=1S/C20H14N4O12S4.2Na/c25-37(26,27)11-5-13-17(15(7-11)39(31,32)33)23-19(21-13)9-1-2-10(4-3-9)20-22-14-6-12(38(28,29)30)8-16(18(14)24-20)40(34,35)36;;/h1-8H,(H,21,23)(H,22,24)(H,25,26,27)(H,28,29,30)(H,31,32,33)(H,34,35,36);;/q;2*+1/p-2 Y
    Key: GLCJMPWWQKKJQZ-UHFFFAOYSA-L Y
  • InChI=1/C20H14N4O12S4.2Na/c25-37(26,27)11-5-13-17(15(7-11)39(31,32)33)23-19(21-13)9-1-2-10(4-3-9)20-22-14-6-12(38(28,29)30)8-16(18(14)24-20)40(34,35)36;;/h1-8H,(H,21,23)(H,22,24)(H,25,26,27)(H,28,29,30)(H,31,32,33)(H,34,35,36);;/q;2*+1/p-2
    Key: GLCJMPWWQKKJQZ-NUQVWONBAQ
SMILES
  • C1=CC(=CC=C1C2=NC3=C(C=C(C=C3N2)S(=O)(=O)O)S(=O)(=O)[O-])C4=NC5=C(C=C(C=C5N4)S(=O)(=O)O)S(=O)(=O)[O-].[Na+].[Na+]
Properties
Chemical formula
 C20H12N4Na2O12S4
Molar mass 674.55 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)
Infobox references

Bisdisulizole disodium is not approved in the United States by the FDA, but it has been approved in the European Union since the year 2000[3] and other parts of the world.[4][5]

References
  1. http://ec.europa.eu/enterprise/cosmetics/cosing/index.cfm?fuseaction=search.detailsPDF&id=75792%5B%5D
  2. "Statement on a nonproprietary name adopted by the USAN Council: Bisdisulizole disodium" (PDF). American Medical Association. April 4, 2006. Retrieved 2008-01-08.
  3. Osstervalder U, Luther H, Herzog B (2001). "Über den Lichtschutzfaktor hinaus - neue effiziente und photostabile UVA-Filter". Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz (in German). 44 (5): 463–70. doi:10.1007/s001030170019. S2CID 36985446.
  4. "10. Sunscreens" (PDF). Australian regulatory guidelines for OTC medicines. Commonwealth Department of Health and Ageing, Therapeutic Goods Administration. July 1, 2003. p. 14. Archived from the original (PDF) on August 31, 2007. Retrieved 2008-01-08.
  5. "Symrise UV protection products" (PDF). Symrise. Archived from the original (PDF) on 2008-08-21. Retrieved 2008-08-10.


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