Tumor-associated glycoprotein 72

Tumor-associated glycoprotein 72 (TAG-72) is a glycoprotein found on the surface of many cancer cells, including ovary, breast, colon, lung, and pancreatic cancers.[1][2] It is a mucin-like molecule with a molar mass of over 1000 kDa.[3]

TAG-72 is a tumor marker measured with radioimmunoassays like CA 72-4, which uses the monoclonal antibodies indium (111In) satumomab pendetide and iodine (125I) minretumomab.[4][5][6][7][8] This assay has a good specificity for gastric cancer, with a correlation to the neoplasia's extension. It is used to identify relapses of the disease and to follow up the treatment.

TAG-72 is also the target of the anti-cancer drugs anatumomab mafenatox and minretumomab.

References
  1. TAG-72 antigen entry in the public domain NCI Dictionary of Cancer Terms
  2. Scott, Andrew M.; Wolchok, Jedd D.; Old, Lloyd J. (2012). "Antibody therapy of cancer". Nature Reviews Cancer. 12 (4): 278–87. doi:10.1038/nrc3236. PMID 22437872. S2CID 205469234.
  3. Sheer, Donald G.; Schlom, J; Cooper, HL (1988). "Purification and Composition of the Human Tumor-associated Glycoprotein (TAG-72) Defined by Monoclonal Antibodies CC49 and B72.3". Cancer Research. 48 (23): 6811–6818. PMID 3180090.
  4. Louhimo J, Alfthan H, Stenman UH, Haglund C (2004). "Serum HCG beta and CA 72-4 are stronger prognostic factors than CEA, CA 19-9 and CA 242 in pancreatic cancer". Oncology. 66 (2): 126–31. doi:10.1159/000077438. PMID 15138364. S2CID 25798287.
  5. Louhimo J, Carpelan-Holmström M, Alfthan H, Stenman UH, Järvinen HJ, Haglund C (October 2002). "Serum HCG beta, CA 72-4 and CEA are independent prognostic factors in colorectal cancer". Int. J. Cancer. 101 (6): 545–8. doi:10.1002/ijc.90009. PMID 12237895.
  6. Louhimo J, Kokkola A, Alfthan H, Stenman UH, Haglund C (October 2004). "Preoperative hCGbeta and CA 72-4 are prognostic factors in gastric cancer". Int. J. Cancer. 111 (6): 929–33. doi:10.1002/ijc.20321. PMID 15300805. S2CID 24698852.
  7. Mattar R, Alves de Andrade CR, DiFavero GM, Gama-Rodrigues JJ, Laudanna AA (2002). "Preoperative serum levels of CA 72-4, CEA, CA 19-9, and alpha-fetoprotein in patients with gastric cancer". Rev Hosp Clin Fac Med Sao Paulo. 57 (3): 89–92. doi:10.1590/s0041-87812002000300001. PMID 12118264.
  8. Guadagni F, Roselli M, Cosimelli M, et al. (November 1996). "Correlation between tumor-associated glycoprotein 72 mucin levels in tumor and serum of colorectal patients as measured by the quantitative CA 72-4 immunoassay". Cancer Res. 56 (22): 5293–8. PMID 8912871.

 This article incorporates public domain material from Dictionary of Cancer Terms. U.S. National Cancer Institute.


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