HBQ1

HBQ1
Identifiers
Aliases	HBQ1, HBQ, hemoglobin subunit theta 1
External IDs	OMIM: 142240 MGI: 3613460 HomoloGene: 3895 GeneCards: HBQ1
Gene location (Human)
Chr.	Chromosome 16 (human)[1]
End	181,179 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	32,237,784 bp[2]
RNA expression pattern
	Top expressed in
	blood; ; monocyte; ; cancellous bone; ; nucleus accumbens; ; bone marrow; ; amygdala; ; Brodmann area 9; ; caudate nucleus; ; putamen; ; hypothalamus;
	Top expressed in
	bone marrow; ; yolk sac; ; spleen; ; lobe of liver; ; placenta; ; superior frontal gyrus; ; neural tube; ; mesencephalon; ; cerebellar cortex; ; heart;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	iron ion binding; oxygen binding; protein binding; heme binding; metal ion binding; oxygen carrier activity; peroxidase activity; haptoglobin binding; organic acid binding;
Cellular component	hemoglobin complex; haptoglobin-hemoglobin complex;
Biological process	oxygen transport; hydrogen peroxide catabolic process; protein heterooligomerization; cellular oxidant detoxification;
	Sources:Amigo / QuickGO
Orthologs
	3049
	544763
	ENSG00000086506
	ENSMUSG00000073063
	P09105
	Q3U0A6
	NM_005331
	NM_001033981
	NP_005322
	NP_001029153
	Wikidata
View/Edit Human	View/Edit Mouse

Hemoglobin subunit theta-1 is a protein that in humans is encoded by the HBQ1 gene.[5][6]

Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue.[6]

References

GRCh38: Ensembl release 89: ENSG00000086506 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000073063 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (May 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood. 73 (5): 1081–104. doi:10.1182/blood.V73.5.1081.1081. PMID 2649166.
"Entrez Gene: HBQ1 hemoglobin, theta 1".

Giardina B, Messana I, Scatena R, Castagnola M (1995). "The multiple functions of hemoglobin". Crit. Rev. Biochem. Mol. Biol. 30 (3): 165–96. doi:10.3109/10409239509085142. PMID 7555018.
Kim JH, Yu CY, Bailey A, et al. (1989). "Unique sequence organization and erythroid cell-specific nuclear factor-binding of mammalian theta 1 globin promoters". Nucleic Acids Res. 17 (14): 5687–700. doi:10.1093/nar/17.14.5687. PMC 318189. PMID 2569721.
Ley TJ, Maloney KA, Gordon JI, Schwartz AL (1989). "Globin gene expression in erythroid human fetal liver cells". J. Clin. Invest. 83 (3): 1032–8. doi:10.1172/JCI113944. PMC 303780. PMID 2921315.
Gonzalez-Redondo JM, Han IS, Gu YC, Huisman TH (1988). "Nucleotide sequence of the human theta 1-globin gene". Biochem. Genet. 26 (3–4): 207–11. doi:10.1007/BF00561460. PMID 3408475. S2CID 19352648.
Hsu SL, Marks J, Shaw JP, et al. (1988). "Structure and expression of the human theta 1 globin gene". Nature. 331 (6151): 94–6. Bibcode:1988Natur.331...94H. doi:10.1038/331094a0. PMID 3422341. S2CID 4357357.
Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
De Gobbi M, Viprakasit V, Hughes JR, et al. (2006). "A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter". Science. 312 (5777): 1215–7. Bibcode:2006Sci...312.1215D. doi:10.1126/science.1126431. PMID 16728641. S2CID 16044469.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000086506 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000073063 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2649166-5] Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (May 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood. 73 (5): 1081–104. doi:10.1182/blood.V73.5.1081.1081. PMID 2649166.

[entrez-6] "Entrez Gene: HBQ1 hemoglobin, theta 1".

HBQ1

References

Further reading