Macacine gammaherpesvirus 4

Macacine gammaherpesvirus 4 (McHV-4), commonly known as rhesus lymphocryptovirus (RLV), is a species of virus in the genus Lymphocryptovirus, subfamily Gammaherpesvirinae, family Herpesviridae, and order Herpesvirales.[1]

Macacine gammaherpesvirus 4
Virus classification
(unranked): Virus
Realm: Duplodnaviria
Kingdom: Heunggongvirae
Phylum: Peploviricota
Class: Herviviricetes
Order: Herpesvirales
Family: Herpesviridae
Genus: Lymphocryptovirus
Species:
Macacine gammaherpesvirus 4
Synonyms
  • Rhesus lymphocryptovirus
  • Cercopithecine herpesvirus 15
  • Rhesus HHV-4-like virus
  • Rhesus Epstein Barr virus
  • Rhesus EBV-like herpesvirus

In nature, Macacine gammaherpesvirus 4 infects rhesus macaques (Macaca mulatta).

Comparison with Human gammaherpesvirus 4

Its genetic structure has been fully sequenced and found to be highly homologous with that of Human gammaherpesvirus 4, commonly known as Epstein-Barr virus, at 65%. The structural proteins are highly conserved, while genes expressed during Human gammaherpesvirus 4 latent infection are much less well conserved. Even in cases where genes have low homology, the Macacine gammaherpesvirus 4 infection genes are functionally interchangeable with Human gammaherpesvirus 4 genes.[2]

Macacine gammaherpesvirus 4 infection in rhesus monkeys resembles Human gammaherpesvirus 4 infection in humans in several respects:

These features make the rhesus lymphocryptovirus potentially useful for studying the pathogenesis, prevention, and treatment of Human gammaherpesvirus 4 infection and associated oncogenesis.[3]

References
Wikispecies has information related to Macacine gammaherpesvirus 4.
  1. "ICTV Master Species List 2018b.v2". International Committee on Taxonomy of Viruses (ICTV). Retrieved 19 June 2019.
  2. Rivailler P, Jiang H, Cho YG, Quink C, Wang F (2002). "Complete nucleotide sequence of the rhesus lymphocryptovirus: genetic validation for an Epstein-Barr virus animal model". J. Virol. 76 (1): 421–6. doi:10.1128/jvi.76.1.421-426.2002. PMC 135707. PMID 11739708.
  3. Amir Moghaddam; Michael Rosenzweig; David Lee-Parritz; Bethany Annis; R. Paul Johnson; Fred Wang (1997). "An Animal Model for Acute and Persistent Epstein-Barr Virus Infection". Science. 276 (5321): 2030–2033. doi:10.1126/science.276.5321.2030. PMID 9197263.
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