Monoethanolamine oleate

Monoethanolamine oleate (properly ethanolammonium oleate) is an antivaricose agent. It is a salt formed by Lowry–Brønsted acid–base reaction between monoethanolamine and oleic acid, is systematically named 2-hydroxyethylammonium (9Z)-octadecenoate, and has a structural formula [CH3(CH2)7CH=CH(CH2)7CO2][H3NCH2CH2OH]. It is injected topically into varicosities to cause sclerosis (closure) of the abnormal vein.

Ethanolamine Oleate
Clinical data
AHFS/Drugs.comMultum Consumer Information
ATC code
Identifiers
IUPAC name
  • 2-Hydroxyethylammonium oleate
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.017.163
Chemical and physical data
FormulaC20H41NO3
Molar mass343.552 g·mol−1
Density0.974 g/cm3
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Uses

Ethanolamine Oleate (Ethanolamin) injection is indicated for the treatment of patients with esophageal varices that have recently bled, to prevent rebleeding.

Ethanolamin is not indicated for the treatment of patients with esophageal varices that have not bled. There is no evidence that treatment of this population decreases the likelihood of bleeding.

Sclerotherapy with Ethanolamin has no beneficial effect upon portal hypertension, the cause of esophageal varices, so that recanalization and collateralization may occur, necessitating reinjection.[1]

References
  1. "Ethanolamine Oleate". RXList. Retrieved 7 March 2020.


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