Phenylmercuric nitrate

Phenylmercuric nitrate is an organomercury compound with powerful antiseptic and antifungal effects.[1] It was once commonly used as a topical solution for disinfecting wounds, but as with all organomercury compounds it is highly toxic, especially to the kidneys, and is no longer used in this application. However it is still used in low concentrations as a preservative in eye drops for ophthalmic use, making it one of the few organomercury derivatives remaining in current medical use.[2]

Phenylmercuric nitrate
Names
IUPAC name
nitrooxy(phenyl)mercury
Identifiers
CAS Number
3D model (JSmol)
ChEBI
ChemSpider
ECHA InfoCard 100.000.221
EC Number
  • 200-242-9
PubChem CID
RTECS number
  • OW8400000
UNII
UN number 1895
InChI
  • InChI=1S/C6H5.Hg.NO3/c1-2-4-6-5-3-1;;2-1(3)4/h1-5H;;/q;+1;-1
    Key: PDTFCHSETJBPTR-UHFFFAOYSA-N
SMILES
  • C1=CC=C(C=C1)[Hg]O[N+](=O)[O-]
Properties
Chemical formula
 C6H5HgNO3
Molar mass 339.702 g/mol
Melting point 176–186 °C (349–367 °F; 449–459 K)
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
 Toxic
GHS labelling:
Pictograms
Signal word
 Danger
Hazard statements
 H301, H314, H372, H410
Precautionary statements
 P260, P264, P270, P273, P280, P301+P310, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P314, P321, P330, P363, P391, P405, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

See also

References
  1. Xu, Y.; He, Y.; Li, X.; Gao, C.; Zhou, L.; Sun, S.; Pang, G. (2013). "Antifungal effect of ophthalmic preservatives phenylmercuric nitrate and benzalkonium chloride on ocular pathogenic filamentous fungi". Diagnostic Microbiology and Infectious Disease. 75 (1): 64–7. doi:10.1016/j.diagmicrobio.2012.09.008. PMID 23102555.
  2. Kaur, I. P.; Lal, S.; Rana, C.; Kakkar, S.; Singh, H. (2009). "Ocular preservatives: Associated risks and newer options". Cutaneous and Ocular Toxicology. 28 (3): 93–103. doi:10.1080/15569520902995834. PMID 19505226. S2CID 9806996.


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