Pol (HIV)
Pol (DNA polymerase) refers to a gene in retroviruses, or the protein produced by that gene.
The Gag-Pol region containing the protease gene flanked by p6pol at the N-terminus and reverse transcriptase at the C-terminus.
Products of pol include:
Reverse transcriptase
Common to all retroviruses, this enzyme transcribes the viral RNA into double-stranded DNA.
Integrase
This enzyme integrates the DNA produced by reverse transcriptase into the host's genome.
Protease
A protease is any enzyme that cuts proteins into segments. HIV's gag and pol genes do not produce their proteins in their final form, but as larger combination proteins; the specific protease used by HIV cleaves these into separate functional units. Protease inhibitor drugs block this step.
See also
- Gag/pol translational readthrough site
External links
- Gene+Products,+pol at the US National Library of Medicine Medical Subject Headings (MeSH)
- pol+Gene+Products,+Human+Immunodeficiency+Virus at the US National Library of Medicine Medical Subject Headings (MeSH)
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