Propazepine

Propazepine is a tricyclic antidepressant (TCA).[1] Propazepine is sometimes confused with imipramine, which has the central ring nitrogen in a different location.[1] Prazepine is the International nonproprietary name of this compound.[2] Prazepine is also reported to be one of the many synonyms of imipramine.[3] Propazepine can be synthesized chemically.[4][5] Propazepine appears to never have actually been used as a tricyclic antidepressant outside of initial medical tests; therefore, there is little information about it.

Not to be confused with Prazepam.
Not to be confused with Imipramine.
Propazepine
Names
Preferred IUPAC name
3-(6,11-Dihydro-5H-dibenzo[b,e]azepin-5-yl)-N,N-dimethylpropan-1-amine
Other names
Prazepine, Proazepine
Identifiers
CAS Number
3D model (JSmol)
ChemSpider
PubChem CID
UNII
SMILES
  • CN(C)CCCN1CC2=CC=CC=C2CC3=CC=CC=C31
Properties
Chemical formula
 C19H24N2
Molar mass 280.415 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

References
  1. Benešová, O.; Bohdanecký, Z.; Votava, Z. (1962). "Electrophysiological comparison of the action of imipramine and propazepine". Psychopharmacologia. 3 (6): 423–431. doi:10.1007/BF00411159. PMID 13967414. S2CID 1109255.
  2. "Propazepine – C19H24N2". Pubchem.
  3. "Imipramine – C19H24N2". ChemSpider.
  4. Werner, L. H.; Ricca, S.; Mohacsi, E.; Rossi, A.; Arya, V. P. (1965). "Derivatives of Morphanthridine". Journal of Medicinal Chemistry. 8: 74–80. doi:10.1021/jm00325a016. PMID 14287270.
  5. Jílek, J. O.; Pomykáček, J.; Svátek, E.; Seidlová, V.; Rajšner, M.; Pelz, K.; Hoch, B.; Protiva, M. (1965). "Neurotrope und psychotrope substanzen II. Morphanthridin und derivate. Neue synthese des propazepins" [Neurotropic and psychotropic substances II. Morphanthridin and derivatives. New Synthesis of propazepins]. Collection of Czechoslovak Chemical Communications (in Czech). 30 (2): 445–462. doi:10.1135/cccc19650445.

Further reading
  • Vojtechovsky, M; Safratova, V; Soukupova, B (1970). "The influence of propazepine on learning and memory in healthy volunteers and in patients with slight chronic brain syndrome". Activitas Nervosa Superior (in Czech). 12 (3): 251–2. ISSN 0001-7604. PMID 5457443.
  • Rysánek, K; Vítek, V; Svehla, C (1965). "Serotonin level in human and animal thrombocytes after imipramine and propazepine administration". Activitas Nervosa Superior (in Czech). 7 (3): 261–2. ISSN 0001-7604. PMID 5882104.
  • Souskova, M; Votava, Z; Roth, Z (1964). "Effect of Iproniazid, Propazepine, Reserpine and Their Combinations on the Orientation Reaction and Conditioned Defense Reaction in Rats". Activitas Nervosa Superior (in Czech). 6: 258–67. ISSN 0001-7604. PMID 14179381.
  • Vinarova, M; Nahunek, K; Vencovsky, E; Bast Ecky, J; Hadlik, J (1962). "Blind comparison of clinical effects of Imipramine and Propazepine". Activitas Nervosa Superior (in Czech). 4: 227–8. ISSN 0001-7604. PMID 13926058.
  • Souskova, M; Votava, Z (1962). "Comparative studies on the effect of Imipramine and Propazepine by a conditioned reflex method in rats". Activitas Nervosa Superior (in Czech). 4: 218–9. ISSN 0001-7604. PMID 13915453.
  • Benesova, O; Bohdanecky, Z; Votava, Z (1962). "Comparative studies on the effect of Imipramine and Propazepine by electrophysiological methods on animals with implanted electrodes". Activitas Nervosa Superior (in Czech). 4: 215–6. ISSN 0001-7604. PMID 13867184.
  • Metysova, J; Votava, Z (1961). "Comparison of pharmacological properties of propazepine and imipramine". Activitas Nervosa Superior (in Czech). 3: 227. ISSN 0001-7604. PMID 14473038.


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