Sodium picosulfate

Sodium picosulfate (INN, also known as sodium picosulphate) is a contact stimulant laxative used as a treatment for constipation or to prepare the large bowel before colonoscopy or surgery. It is sold under the trade names Sodipic Picofast, Laxoberal, Laxoberon,[1] Purg-Odan, Picolax, Guttalax, Namilax, Pico-Salax,[2] PicoPrep,[3] and Prepopik,[4] among others.

Sodium picosulfate
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral
ATC code
Identifiers
IUPAC name
  • disodium (pyridin-2-ylmethylene)di-4,1-phenylene disulfate
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.030.097
Chemical and physical data
FormulaC18H13NNa2O8S2
Molar mass481.40 g·mol−1
3D model (JSmol)
SMILES
  • [Na+].[Na+].[O-]S(=O)(=O)Oc1ccc(cc1)C(c2ccc(OS([O-])(=O)=O)cc2)c3ncccc3
InChI
  • InChI=1S/C18H15NO8S2.2Na/c20-28(21,22)26-15-8-4-13(5-9-15)18(17-3-1-2-12-19-17)14-6-10-16(11-7-14)27-29(23,24)25;;/h1-12,18H,(H,20,21,22)(H,23,24,25);;/q;2*+1/p-2 Y
  • Key:GOZDTZWAMGHLDY-UHFFFAOYSA-L Y
 NY (what is this?)  (verify)

Effects

Orally administered sodium picosulfate is generally used for thorough evacuation of the bowel, usually for patients who are preparing to undergo a colonoscopy. It takes 12–24 hours to work, since it works in the colon.[4]

Abdominal cramps and diarrhea are normal effects of picosulfate and should be expected.

The use of sodium picosulfate has also been associated with certain electrolyte disturbances, such as hyponatremia and hypokalemia.[5] Patients are often required to drink large amounts of clear fluids, to compensate for dehydration and to reestablish normal electrolyte balance.

Mechanism of action

Sodium picosulfate is a prodrug.[6] It has no significant direct physiological effect on the intestine; however, it is metabolised by gut bacteria into the active compound 4,4'-dihydroxydiphenyl-(2-pyridyl)methane (DPM, BHPM).[6][7] This compound is a stimulant laxative and increases peristalsis in the gut.[6][8]

Sodium picosulfate is typically prescribed in a combined formulation with magnesium citrate, an osmotic laxative. This combination is a highly effective laxative, often prescribed to patients for bowel cleansing prior to colonoscopies.[6][9]

References
  1. Website of Merck Pakistan
  2. PICO SALAX Product Information Archived 2012-03-22 at the Wayback Machine
  3. Tjandra JJ, Chan M, Tagkalidis PP (May 2006). "Oral sodium phosphate (Fleet) is a superior colonoscopy preparation to Picopre (sodium picosulfate-based preparation)". Diseases of the Colon and Rectum. 49 (5): 616–20. doi:10.1007/s10350-005-0323-2. PMID 16525746. S2CID 36729352.
  4. "FDA News Release – FDA approves new colon-cleansing drug for colonoscopy prep". Food and Drug Administration. July 17, 2012. Retrieved December 1, 2016.
  5. ADRAC (February 2002). "Electrolyte disturbances with sodium picosulfate bowel cleansing products". Aust Adv Drug React Bull. 21 (1). Free full text from the Australian Therapeutic Goods Administration
  6. Adamcewicz M, Bearelly D, Porat G, Friedenberg FK (January 2011). "Mechanism of action and toxicities of purgatives used for colonoscopy preparation". Expert Opinion on Drug Metabolism & Toxicology. 7 (1): 89–101. doi:10.1517/17425255.2011.542411. PMC 3030244. PMID 21162694.
  7. Forth W, Nell G, Rummel W, Andres H (1972-03-01). "The hydragogue and laxative effect of the sulfuric acid ester and the free diphenol of 4,4'-dihydroxydiphenyl-(pyridyl-2)-methane". Naunyn-Schmiedeberg's Archives of Pharmacology. 274 (1): 46–53. doi:10.1007/BF00501005. PMID 4262724. S2CID 13177533.
  8. Jauch R, Hankwitz R, Beschke K, Pelzer H (November 1975). "Bis-(p-hydroxyphenyl)-pyridyl-2-methane: The common laxative principle of Bisacodyl and sodium picosulfate". Arzneimittel-Forschung. 25 (11): 1796–1800. PMID 1243088.
  9. Regev A, Fraser G, Delpre G, Leiser A, Neeman A, Maoz E, et al. (September 1998). "Comparison of two bowel preparations for colonoscopy: sodium picosulphate with magnesium citrate versus sulphate-free polyethylene glycol lavage solution". The American Journal of Gastroenterology. 93 (9): 1478–82. doi:10.1111/j.1572-0241.1998.00467.x. PMID 9732929. S2CID 7579449.
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