Streptococcus gordonii

Streptococcus gordonii is a Gram-positive bacterium included among some of the initial colonizers of the periodontal environment.[1] The organism, along with related oral streptococci, has a high affinity for molecules in the salivary pellicle (or coating) on tooth surfaces. S. gordonii therefore can rapidly colonize clean tooth surfaces, and S. gordonii along with related organisms comprise a high percentage, up to 70%, of the bacterial biofilm that forms on clean tooth surfaces. Generally harmless in the mouth, S. gordonii can cause acute bacterial endocarditis upon gaining access systemically. S. gordonii also forms an attachment substratum for later colonizers of tooth surface and can modulate the pathogenicity of these secondary colonizers through interspecies communication mechanisms.

Streptococcus gordonii
Scientific classification
Domain: Bacteria
Phylum: Bacillota
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
Species:
S. gordonii
Binomial name
Streptococcus gordonii
Kilian et al. 1989

The whole genome sequence of S. gordonii CCUG 33482 type strain was deposited and published in DNA Data Bank of Japan, European Nucleotide Archive and GenBank in 2016 under the accession number LQWV00000000.[2]

DNA repair

Upon systemic infection, S. gordonii is subjected to conditions in human blood that damage its DNA. However, DNA damage can be tolerated by the use of DNA repair processes.[3] The S. gordonii genome encodes a two protein complex, RexAB, that is employed in recombinational repair and can promote survival by repairing DNA double-strand breaks.[3]


References
  1. American Academy of Periodontology 2010 In-Service Exam, question 82
  2. Salvà-Serra, Francisco; Jakobsson, Hedvig E.; Thorell, Kaisa; Gonzales-Siles, Lucia; Hallbäck, Erika T.; Jaén-Luchoro, Daniel; Boulund, Fredrik; Sikora, Per; Karlsson, Roger (2016-04-28). "Draft Genome Sequence of Streptococcus gordonii Type Strain CCUG 33482T". Genome Announcements. 4 (2): e00175–16. doi:10.1128/genomeA.00175-16. ISSN 2169-8287. PMC 4807240. PMID 27013051.
  3. Ha KP, Clarke RS, Kim GL, Brittan JL, Rowley JE, Mavridou DAI, Parker D, Clarke TB, Nobbs AH, Edwards AM. Staphylococcal DNA Repair Is Required for Infection. mBio. 2020 Nov 17;11(6):e02288-20. doi: 10.1128/mBio.02288-20. PMID: 33203752; PMCID: PMC7683395


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