Urine protein/creatinine ratio

Urine protein/creatinine ratio is a widely used initial method to estimate daily protein excretion in urine.[1][2][3] Since the diagnosis and management of proteinuric renal diseases and the staging of chronic kidney disease depend on accurate identification and quantitation of proteinuria,[4][1] the implementation of the 24-hour urine collection is the most accurate procedure in practice to figure out the urinary protein excretion.[1] However, in current clinical practice, the urine protein/creatinine ratio is widely used to estimate daily protein excretion by virtue of its convenience and simplicity.[5][1]

The difference between urine protein/creatinine ratio and 24-hour urine collection is that former requires a urine sample to be collected only once at any time.[6] [Creatinine(U)] is taken into account due to the notion that creatinine is normally released into the urine at a constant rate.[6] Scientists found that the ratio of protein to creatinine roughly estimates the actual value gained from the 24-hour urine protein test.[6] The normal urine protein/creatinine ratio is not more than 200 mg/g.[7]

References
  1. Yang, Chih-Yu; Chen, Fu-An; Chen, Chun-Fan; Liu, Wen-Sheng; Shih, Chia-Jen; Ou, Shuo-Ming; Yang, Wu-Chang; Lin, Chih-Ching; Yang, An-Hang (2015-09-09). Kim, Jayoung (ed.). "Diagnostic Accuracy of Urine Protein/Creatinine Ratio Is Influenced by Urine Concentration". PLOS ONE. Public Library of Science (PLoS). 10 (9): e0137460. Bibcode:2015PLoSO..1037460Y. doi:10.1371/journal.pone.0137460. ISSN 1932-6203. PMC 4564100. PMID 26353117.
  2. "Protein urine test: MedlinePlus Medical Encyclopedia". MedlinePlus. 2019-05-08. Retrieved 2019-05-21.
  3. "Protein in Urine: MedlinePlus Lab Test Information". MedlinePlus. 2019-04-15. Retrieved 2019-05-21.
  4. National Kidney Foundation (2002), "K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification", American Journal of Kidney Diseases, 39 (2 Suppl 1): S1–266, ISSN 0272-6386, PMID 11904577
  5. Ginsberg, Jay M.; Chang, Bruce S.; Matarese, Richard A.; Garella, Serafino (1983-12-22). "Use of Single Voided Urine Samples to Estimate Quantitative Proteinuria". The New England Journal of Medicine. Massachusetts Medical Society. 309 (25): 1543–1546. doi:10.1056/nejm198312223092503. ISSN 0028-4793. PMID 6656849.
  6. "Urine Protein". Lab Tests Online. Retrieved 2019-05-21.
  7. "Summary of Recommendation Statements". Kidney International Supplements. Elsevier BV. 3 (1): 5–14. 2013. doi:10.1038/kisup.2012.77. ISSN 2157-1716. PMC 4284512. PMID 25598998.
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