COPS2

Subunidad 2 del complejo signalosoma COP9
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB
Identificadores
Símbolos	COPS2 (HGNC: 30747) CSN2, ALIEN, SGN2, TRIP15
Identificadores; externos	OMIM: 604508 ; EBI: COPS2; GeneCards: Gen COPS2; UniProt: COPS2;
Locus	Cr. 15 q21.1
	Referencias: AmiGO / QuickGO
Ortólogos
Humano	Ratón
9318
P61201	n/a
NP_004227	n/a

La subunidad 2 del complejo signalosoma COP9 (COPS2)es una proteína que es codificada, en humanos, por el gen cops2.[1][2][3]

Interacciones

La proteína COPS2 ha demostrado ser capaz de interaccionar con:

Referencias

Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (Jul de 1995). «Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor». Mol Endocrinol 9 (2): 243-54. PMID 7776974.
Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, Gordon C, Naumann M, Dubiel W (Apr de 1998). «A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits». FASEB J 12 (6): 469-78. PMID 9535219.
«Entrez Gene: COPS2 COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)».
Cohen, H; Azriel A, Cohen T, Meraro D, Hashmueli S, Bech-Otschir D, Kraft R, Dubiel W, Levi B Z (Dec. de 2000). «Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome». J. Biol. Chem. (UNITED STATES) 275 (50): 39081-9. ISSN 0021-9258. PMID 10991940. doi:10.1074/jbc.M004900200.
Akiyama, Hirotada; Fujisawa Naoko, Tashiro Yousuke, Takanabe Natsuko, Sugiyama Akinori, Tashiro Fumio (Mar. de 2003). «The role of transcriptional corepressor Nif3l1 in early stage of neural differentiation via cooperation with Trip15/CSN2». J. Biol. Chem. (United States) 278 (12): 10752-62. ISSN 0021-9258. PMID 12522100. doi:10.1074/jbc.M209856200.
Dressel, U; Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum S P, Renkawitz R, Baniahmad A (mayo. de 1999). «Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily». Mol. Cell. Biol. (UNITED STATES) 19 (5): 3383-94. ISSN 0270-7306. PMID 10207062.
Altincicek, B; Tenbaum S P, Dressel U, Thormeyer D, Renkawitz R, Baniahmad A (Mar. de 2000). «Interaction of the corepressor Alien with DAX-1 is abrogated by mutations of DAX-1 involved in adrenal hypoplasia congenita». J. Biol. Chem. (UNITED STATES) 275 (11): 7662-7. ISSN 0021-9258. PMID 10713076.

Enlaces externos

MeSH: COPS2+protein,+human (en inglés)

Datos: Q18033996

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[pmid7776974-1] Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (Jul de 1995). «Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor». Mol Endocrinol 9 (2): 243-54. PMID 7776974.

[pmid9535219-2] Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, Gordon C, Naumann M, Dubiel W (Apr de 1998). «A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits». FASEB J 12 (6): 469-78. PMID 9535219.

[entrez-3] «Entrez Gene: COPS2 COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)».

[pmid10991940-4] Cohen, H; Azriel A, Cohen T, Meraro D, Hashmueli S, Bech-Otschir D, Kraft R, Dubiel W, Levi B Z (Dec. de 2000). «Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome». J. Biol. Chem. (UNITED STATES) 275 (50): 39081-9. ISSN 0021-9258. PMID 10991940. doi:10.1074/jbc.M004900200.

[pmid12522100-5] Akiyama, Hirotada; Fujisawa Naoko, Tashiro Yousuke, Takanabe Natsuko, Sugiyama Akinori, Tashiro Fumio (Mar. de 2003). «The role of transcriptional corepressor Nif3l1 in early stage of neural differentiation via cooperation with Trip15/CSN2». J. Biol. Chem. (United States) 278 (12): 10752-62. ISSN 0021-9258. PMID 12522100. doi:10.1074/jbc.M209856200.

[pmid10207062-6] Dressel, U; Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum S P, Renkawitz R, Baniahmad A (mayo. de 1999). «Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily». Mol. Cell. Biol. (UNITED STATES) 19 (5): 3383-94. ISSN 0270-7306. PMID 10207062.

[pmid10713076-7] Altincicek, B; Tenbaum S P, Dressel U, Thormeyer D, Renkawitz R, Baniahmad A (Mar. de 2000). «Interaction of the corepressor Alien with DAX-1 is abrogated by mutations of DAX-1 involved in adrenal hypoplasia congenita». J. Biol. Chem. (UNITED STATES) 275 (11): 7662-7. ISSN 0021-9258. PMID 10713076.