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HPV-Associated Cancer Trends Among Men by Year

The rate of people getting HPV-associated cancers varies by year and type of cancer. “Incidence rate” means how many people out of a given number get the disease each year.

*Note: This study used cancer registry data to estimate the amount of HPV-associated cancer in the United States by examining cancer in parts of the body and cancer cell types that are more likely to be caused by HPV. Cancer registries do not collect data on the presence or absence of HPV in cancer tissue at the time of diagnosis. In general, HPV is thought to be responsible for more than 90% of anal and cervical cancers; more than 50% of vaginal, vulvar, and penile cancers; and 60% to 70% of oropharyngeal cancers.

Number of HPV-Associated Cancers Among Men by Year and Cancer Site, United States, 2003–2013

This graph shows the number of HPV-associated cancers among men by year and cancer site in the United States from 2003 to 2013. Among men diagnosed with HPV-associated penile cancer, there were 1,029 cases in 2003, 983 in 2004, 1,009 in 2005, 1,020 in 2006, 1,102 in 2007, 1,207 in 2008, 1,091 in 2009, 1,165 in 2010, 1,213 in 2011, 1,194 in 2012, and 1,241 in 2013. Among men diagnosed with HPV-associated anal cancer, there were 1,319 cases in 2003, 1,323 in 2004, 1,503 in 2005, 1,386 in 2006, 1,555 in 2007, 1,663 in 2008, 1,800 in 2009, 1,730 in 2010, 1,777 in 2011, 1,849 in 2012, and 1,910 in 2013. Among men diagnosed with HPV-associated rectal cancer, there were 184 cases in 2003, 181 in 2004, 202 in 2005, 220 in 2006, 223 in 2007, 229 in 2008, 260 in 2009, 226 in 2010, 219 in 2011, 253 in 2012, and 261 in 2013. Among men diagnosed with HPV-associated oropharyngeal cancer, there were 8,782 cases in 2003, 9,421 in 2004, 9,512 in 2005, 9,915 in 2006, 10,875 in 2007, 11,668 in 2008, 12,198 in 2009, 12,493 in 2010, 13,424 in 2011, 13,735 in 2012, and 14,532 in 2013.

HPV-Associated Cancer Rates Among Men by Year and Cancer Site, United States, 2003–2013

This graph shows the rates of HPV-associated cancers among men by year and cancer site in the United States from 2003 to 2013. The rates for men diagnosed with HPV-associated penile cancer were stable from 2003 to 2013 and were 0.81 cases per 100,000 men in 2003, 0.76 in 2004, 0.77 in 2005, 0.76 in 2006, 0.81 in 2007, 0.86 in 2008, 0.76 in 2009, 0.80 in 2010, 0.81 in 2011, 0.78 in 2012, and 0.79 in 2013. The rates for men diagnosed with HPV-associated anal cancer increased from 2003 to 2013 and were 0.97 cases per 100,000 men in 2003, 0.96 in 2004, 1.07 in 2005, 0.96 in 2006, 1.06 in 2007, 1.10 in 2008, 1.16 in 2009, 1.11 in 2010, 1.10 in 2011, 1.14 in 2012, and 1.15 in 2013. The rates for men diagnosed with HPV-associated rectal cancer were stable from 2003 to 2013 and were 0.14 cases per 100,000 men in 2003, 0.14 in 2004, 0.15 in 2005, 0.16 in 2006, 0.15 in 2007, 0.16 in 2008, 0.17 in 2009, 0.14 in 2010, 0.14 in 2011, 0.16 in 2012, and 0.16 in 2013. The rates for men diagnosed with HPV-associated oropharyngeal cancer increased from 2003 to 2013 and were 6.31 cases per 100,000 men in 2003, 6.59 in 2004, 6.48 in 2005, 6.58 in 2006, 7.06 in 2007, 7.37 in 2008, 7.53 in 2009, 7.50 in 2010, 7.89 in 2011, 7.91 in 2012, and 8.18 in 2013.

Rates are per 100,000 and age-adjusted to the 2000 U.S. Standard Population (19 age groups — Census P25-1130) standard.

Data are from population-based cancer registries participating in the CDC National Program of Cancer Registries and/or the NCI Surveillance, Epidemiology, and End Results Program, meeting criteria for high data quality for all years 2003–2013, and covering about 99% of the U.S. population.

HPV-associated cancers were defined as cancers at specific anatomic sites and with specific cellular types in which HPV DNA frequently is found. All cancers were confirmed histologically. Cervical cancers (ICD-O-3 site codes C53.0–C53.9) are limited to carcinomas (ICD-O-3 histology codes 8010–8671, 8940–8941). Vaginal (ICD-O-3 site code C52.9), vulvar (ICD-O-3 site codes C51.0–C51.9), penile (ICD-O-3 site codes C60.0–60.9), anal (ICD-O-3 site code C21.0–C21.9), rectal (ICD-O-3 site code C20.9) and oropharyngeal (ICD-O-3 site codes C01.9, C02.4, C02.8, C05.1, C05.2, C09.0, C09.1, C09.8, C09.9, C10.0, C10.1, C10.2, C10.3, C10.4, C10.8, C10.9, C14.0, C14.2 and C14.8) cancer sites are limited to squamous cell carcinomas (ICD-O-3 histology codes 8050–8084, 8120–8131).

Reference

Viens LJ, Henley SJ, Watson M, Markowitz LE, Thomas CC, Thompson TD, Razzaghi H, Saraiya M, Centers for Disease Control and Prevention (CDC). Human papillomavirus–associated cancers—United States, 2008–2012. MMWR 2016;65(26):661–666.

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