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NIOSH

CHLOROFORM

ICSC: 0027

Trichloromethane
Methane trichloride
Formyl trichloride
CHCl3
Molecular mass: 119.4
ICSC # 0027 		CAS # 67-66-3
RTECS # FS9100000
UN # 1888
EC # 602-006-00-4
November 04, 2000 Validated

TYPES OF HAZARD/ EXPOSURE

ACUTE HAZARDS/ SYMPTOMS

PREVENTION

FIRST AID/
FIRE FIGHTING

FIRE Not combustible. See Notes. Gives off irritating or toxic fumes (or gases) in a fire.

In case of fire in the surroundings: use appropriate extinguishing media.
EXPLOSION

In case of fire: keep drums, etc., cool by spraying with water.
EXPOSURE
STRICT HYGIENE! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN!

•INHALATION Cough. Dizziness. Drowsiness. Headache. Nausea. Unconsciousness.
Ventilation, local exhaust, or breathing protection.
Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.
•SKIN Redness. Pain. Dry skin.
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention.
•EYES Redness. Pain.
Face shield or eye protection in combination with breathing protection.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
•INGESTION Abdominal pain. Vomiting. (Further see Inhalation).
Do not eat, drink, or smoke during work.
Rinse mouth. Give plenty of water to drink. Rest. Refer for medical attention.

SPILLAGE DISPOSAL

STORAGE

PACKAGING & LABELLING

Evacuate danger area! Consult an expert! Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Do NOT let this chemical enter the environment. Personal protection: complete protective clothing including self-contained breathing apparatus.
Separated from food and feedstuffs and incompatible materials ,( see Chemical Dangers ). Ventilation along the floor.
Unbreakable packaging; put breakable packaging into closed unbreakable container. Do not transport with food and feedstuffs.
Xn symbol
R: 22-38-40-48/20/22
S: 2-36/37
UN Hazard Class: 6.1
UN Packing Group: III
ICSC: 0027 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

CHLOROFORM

ICSC: 0027

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PHYSICAL STATE; APPEARANCE:
VOLATILE COLOURLESS LIQUID , WITH CHARACTERISTIC ODOUR.

PHYSICAL DANGERS:
The vapour is heavier than air.

CHEMICAL DANGERS:
On contact with hot surfaces or flames this substance decomposes forming toxic and corrosive fumes(hydrogen chloride ICSC0163,phosgene ICSC0007 andchlorine fumes ICSC0126). Reacts violently withstrong bases,strong oxidants, some metals, such as aluminium, magnesium and zinc, causing fire and explosion hazard. Attacks plastic, rubber and coatings.

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 10 ppm as TWA; A3 (confirmed animal carcinogen with unknown relevance to humans); (ACGIH 2004).
MAK: 0.5 ppm, 2.5 mg/m3;
Peak limitation category: II(2);
skin absorption (H);
Carcinogen category: 4; Pregnancy risk group: C;
(DFG 2004).
OSHA PEL†: C 50 ppm (240 mg/m3)
NIOSH REL: Ca ST 2 ppm (9.78 mg/m3) 60-minute See Appendix A
NIOSH IDLH: Ca 500 ppm See: 67663


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

INHALATION RISK:
A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20°C.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance is irritating to the eyes . The substance may cause effects on the central nervous system , liver and kidneys . The effects may be delayed. Medical observation is indicated.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
The liquid defats the skin. The substance may have effects on the liver and kidneys . This substance is possibly carcinogenic to humans.

PHYSICAL
PROPERTIES

Boiling point: 62°C
Melting point: -64°C
Relative density (water = 1): 1.48
Solubility in water, g/100 ml at 20°C: 0.8
Vapour pressure, kPa at 20°C: 21.2
Relative vapour density (air = 1): 4.12
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.7
Octanol/water partition coefficient as log Pow: 1.97

ENVIRONMENTAL
DATA

The substance is toxic to aquatic organisms.

N O T E S

Turns combustible on addition of small amounts of a flammable substance or an increase in the oxygen content of the air. Use of alcoholic beverages enhances the harmful effect. Depending on the degree of exposure, periodic medical examination is indicated. The odour warning when the exposure limit value is exceeded is insufficient. Do NOT use in the vicinity of a fire or a hot surface, or during welding. Card has been partly updated in April 2005. See section Occupational Exposure Limits.
Transport Emergency Card: TEC (R)-61S1888

NFPA Code: H 2; F 0; R 0;

ADDITIONAL INFORMATION



ICSC: 0027 CHLOROFORM
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.
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