SKIN EXPOSURES & EFFECTS

Finite Dose Skin Permeation Calculator

Description

Many models have been developed to calculate the steady-state permeability from an aqueous solution of infinite volume. These do not, however, correspond to a typical occupational exposure scenario. But this calculator estimates fluxes, skin concentrations, and amounts absorbed from any size dose applied to partially or fully hydrated skin. The calculations are based on the model described in the references below.

Various inputs are required: molecular weight (MW), the base-10 logarithm of the octanol-water partition coefficient (logKow), melting point and boiling point of the compound of interest. These and other optional properties may be obtained free from EPI Suite™ or other estimation software packages or databases. Further instructions can be found on the information tab.

This program requires Java installed. It can be downloaded free. Please make sure that Java is enabled in your browser. Upon program loading you may encounter the ActiveX security warning (usually a yellow bar on the top of your browser window), press "Click here for options ...", then press "Allow Blocked Content". A 'Security Warning' window will pop up; press "Yes" to proceed. Additionally, you may be asked through another security warning whether you trust the publisher of this program. Saying "Yes" or "Run" will enable all the program functionality and you will able to save simulation results. If you say "No" or "Cancel" the program will still work, but it will be in the 'demo' mode and you will not be able to save or copy any results.

Requires Java installed. Download Java Free

Inquiries

For general help, contact Adam Fedorowicz.
For technical questions, contact Matthew Miller.

Acknowledgments

The Finite Dose Skin Permeation Calculator was developed by Adam Fedorowicz, Matthew Miller, Gerald Kasting and Fred Frasch and with partial financial support from NIOSH/CDC grant R01 OH007529.

Disclaimer

Neither NIOSH nor the University of Cincinnati warrants or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of the information generated by the Finite Dose Skin Permeation Calculator. You should not rely on any such information for any assessment of the risks of any specific experiment, procedure or process that you wish to carry out; you should always carry out your own risk assessment for such purposes. The information generated by the Finite Dose Skin Permeation Calculator may not be correct or appropriate for local regulations, legal codes, practices or policies. The information may be out of date. Neither NIOSH nor the University of Cincinnati takes responsibility for any injury, loss, or damage caused in any manner whatsoever by the use of the information generated by the Finite Dose Skin Permeation Calculator.

References

1. Kasting, G. B. and M. A. Miller (2006). "Kinetics of finite dose absorption through skin 2. Volatile compounds." Journal of Pharmaceutical Sciences 95(2): 268-280.
2. Miller, M. A. and G. B. Kasting (2010). "Toward a Better Understanding of Pesticide Dermal Absorption: Diffusion Model Analysis of Parathion Absorption in Vitro and in Vivo." Journal of Toxicology and Environmental Health 73(4): 284 - 300.
3. Kasting, G. B., M. A. Miller, et al. (2008). "A Spreadsheet-Based Method for Estimating the Skin Disposition of Volatile Compounds: Application to N,N-Diethyl-m-Toluamide (DEET)." Journal of Occupational and Environmental Hygiene 5(10): 633-644.
4. Wang, T.-F., G. B. Kasting, et al. (2007). "A multi phase microscopic model for stratum corneum permeability. II. Estimation of physicochemical parameters and application to a large permeability database." Journal of Pharmaceutical Sciences 96(11): 3024-3051.

Keywords

skin permeation, skin penetration, dermal absorption, percutaneous absorption, transdermal drug transport, stratum corneum, viable epidermis, dermis, in silico, mathematical model, skin concentrations, dermal risk assessment