Trichoblastoma

Trichoblastoma

Trichoblastoma is a noncancerous skin tumor of the follicular germinative cells known as trichoblasts.[1]: 673 

Trichoblastic fibroma is a term used to describe small nodular trichoblastomas that contain a conspicuous fibrocytic component, sometimes constituting over 50% of the lesion.[2]

Image at left shows a trichoblastoma from a 68-year-old Caucasian male. It shows a pseudo-encapsulated, multinodular, basaloid tumor with fibrocellular stroma spanning the reticular dermis extending into subcutaneous fat (A). No epidermal connection or retraction artifact was noted. Tumor lobules were arranged as monomorphous basaloid cells in a cribriform pattern with peripheral palisading some resembling abortive hair follicles (B, F). Focally, tumor lobules exhibited squamous eddies, papillary mesenchymal bodies, and a germinative component comprising basaloid cells admixed with distinct pales cells (Zellballen) (C–E, D is an enlargement of boxed area in C).[3]

  • Trichoblastoma
    Trichoblastoma
  • Micrographs of trichoblastoma
    Micrographs of trichoblastoma

See also

References

  1. ↑ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
  2. ↑ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. p. 1698. ISBN 978-1-4160-2999-1.
  3. ↑ Originally copied from: Liu, Xuefeng; Sundberg, John P.; Stearns, Timothy M.; Joh, Joongho; Proctor, Mary; Ingle, Arvind; Silva, Kathleen A.; Dadras, Soheil S.; Jenson, A. Bennett; Ghim, Shin-je (2014). "Immune Status, Strain Background, and Anatomic Site of Inoculation Affect Mouse Papillomavirus (MmuPV1) Induction of Exophytic Papillomas or Endophytic Trichoblastomas". PLOS ONE. 9 (12): e113582. doi:10.1371/journal.pone.0113582. ISSN 1932-6203. PMC 4256377. PMID 25474466.
    "Figure 2- available via license: Creative Commons Attribution 4.0 International"
  4. ↑ Laffay L, Depaepe L, d'Hombres A, Balme B, Thomas L, De Bari B (2012). "Histological features and treatment approach of trichoblastic carcinomas: from a case report to a review of the literature". Tumori. 98 (2): 46e–49e. doi:10.1700/1088.11948. PMID 22678003.
Classification
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