Fenleuton

Fenleuton
Clinical data
Trade names	Lofrin
ATC code	none;
Identifiers
	IUPAC name 1-{4-[3-(4-Fluorophenoxy)phenyl]-3-butyn-2-yl}-1-hydroxyurea;
CAS Number	141579-54-6;
ChemSpider	65045;
UNII	LG64454O6I;
KEGG	D04151;
Chemical and physical data
Formula	C17H15FN2O3
Molar mass	314.316 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C#Cc1cccc(c1)Oc2ccc(cc2)F)N(C(=O)N)O;
	InChI InChI=InChI=1S/C17H15FN2O3/c1-12(20(22)17(19)21)5-6-13-3-2-4-16(11-13)23-15-9-7-14(18)8-10-15/h2-4,7-12,22H,1H3,(H2,19,21); Key:MWXPQCKCKPYBDR-UHFFFAOYSA-N;

Fenleuton (trade name Lofrin) is a drug that acts as a 5-lipoxygenase inhibitor and inhibits leukotriene (LTB4, LTC4, LTD4, and LTE4) formation. It has been studied for potential use in veterinary medicine to treat respiratory diseases such as chronic obstructive pulmonary disease (COPD) in horses.^[2]

References

↑ "1-{4-[3-(4-Fluorophenoxy)phenyl]-3-butyn-2-yl}-1-hydroxyurea". chemspider.com. Retrieved 24 December 2015.
↑ Marr KA, Lees P, Page CP, Cunningham FM (1998). "Effect of the 5-lipoxygenase inhibitor, fenleuton, on antigen-induced neutrophil accumulation and lung function changes in horses with chronic obstructive pulmonary disease". J Vet Pharmacol Ther. 21 (3): 241–246. doi:10.1046/j.1365-2885.1998.00127.x. PMID 9673966.

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