HBG2

HBG2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FDH, 4MQJ, 4MQK
Identifiers
Aliases	HBG2, HBG-T1, TNCY, hemoglobin subunit gamma 2
External IDs	OMIM: 142250 MGI: 96027 HomoloGene: 128032 GeneCards: HBG2
Gene location (Human)
Chr.	Chromosome 11 (human)
End	5,505,605 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	103,853,216 bp
Gene ontology
Molecular function	• iron ion binding; • oxygen carrier activity; • heme binding; • metal ion binding; • oxygen binding; • peroxidase activity; • GO:0001948 protein binding; • haptoglobin binding; • organic acid binding;
Cellular component	• blood microparticle; • hemoglobin complex; • cytosol; • haptoglobin-hemoglobin complex;
Biological process	• oxygen transport; • blood coagulation; • transport; • hydrogen peroxide catabolic process; • protein heterooligomerization; • cellular oxidant detoxification;
	Sources:Amigo / QuickGO
Orthologs
	3048
	15135
	ENSG00000196565
	ENSMUSG00000052187
	P69892
	P02104
	NM_000184
	NM_008221
	NP_000175
	NP_032247
	Wikidata
View/Edit Human	View/Edit Mouse

Hemoglobin subunit gamma-2 is a protein that in humans is encoded by the HBG2 gene.^[5]

Function

The gamma globin genes (HBG1 and HBG2, this gene) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5' - epsilon – gamma-G – gamma-A – delta – beta - 3'.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000196565 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000052187 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (May 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood. 73 (5): 1081–104. doi:10.1182/blood.V73.5.1081.1081. PMID 2649166.
↑ "Entrez Gene: HBG2 hemoglobin, gamma G".

External links

Overview of all the structural information available in the PDB for UniProt: P69892 (Hemoglobin subunit gamma-2) at the PDBe-KB.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000196565 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000052187 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2649166-5] Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (May 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood. 73 (5): 1081–104. doi:10.1182/blood.V73.5.1081.1081. PMID 2649166.

[6] "Entrez Gene: HBG2 hemoglobin, gamma G".

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HBG2

Function

References

Further reading

External links