Iron sucrose

Iron sucrose
Names
Trade namesVenofer, others
IUPAC name
  • disodium;(2R,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol;iron(3+);oxygen(2-);hydroxide;trihydrate
Clinical data
Main usesIron deficiency anemia in chronic kidney disease[1]
Side effectsNausea, diarrhea,low blood pressure, itchiness, joint pain, swelling[1]
WHO AWaReUnlinkedWikibase error: ⧼unlinkedwikibase-error-statements-entity-not-set⧽
Pregnancy
category
  • AU: B3
  • US: B (No risk in non-human studies)
    Routes of
    use    		Intravenous
    External links
    AHFS/Drugs.comMonograph
    MedlinePlusa614017
    Legal
    License data
    Legal status
    Chemical and physical data
    FormulaC12H29Fe5Na2O23
    Molar mass866.546 g·mol−1
    3D model (JSmol)
    SMILES
    • C(C1C(C(C(C(O1)OC2(C(C(C(O2)CO)O)O)CO)O)O)O)O.O.O.O.[OH-].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[Na+].[Na+].[Fe+3].[Fe+3].[Fe+3].[Fe+3].[Fe+3]
    InChI
    • InChI=1S/C12H22O11.5Fe.2Na.4H2O.8O/c13-1-4-6(16)8(18)9(19)11(21-4)23-12(3-15)10(20)7(17)5(2-14)22-12;;;;;;;;;;;;;;;;;;;/h4-11,13-20H,1-3H2;;;;;;;;4*1H2;;;;;;;;/q;5*+3;2*+1;;;;;8*-2/p-1/t4-,5-,6-,7-,8+,9-,10+,11-,12+;;;;;;;;;;;;;;;;;;;/m1.................../s1
    • Key:FWZTTZUKDVJDCM-CEJAUHOTSA-M

    Iron sucrose (IS), sold under the brand name Venofer, is a medication used to treat iron deficiency anemia in people with chronic kidney disease.[1] In this group it works better than iron by mouth.[1] It is given by gradual injection into a vein.[1]

    Common side effects include nausea, diarrhea,low blood pressure, itchiness, joint pain, and swelling.[1] Other side effects may include anaphylaxis.[1] It may have less side effects than iron dextran.[1] Iron sucrose replaces iron in the blood to foster red blood cell production.

    Iron sucrose was approved for medical use in the United States in 2000; however, has been previously used in Europe.[2][3] In the United Kingdom 100 mg costs the NHS about £10 as of 2021.[4] This amount in the United States is about 60 USD.[5]

    Medical uses

    Iron sucrose is a dark brown liquid solution. It is administered intravenously and is only used when a patient with iron deficiency cannot be treated using oral iron options.[6] It is a generally effective drug, with more than 80% of patients responding to treatment. Iron sucrose has ~20 mg of iron per mL of solution. A typical adult patient can safely receive 600 mg of iron sucrose per week, administered in separate doses of 200–300 mg. Most patients experience an increase in their hemoglobin levels of at least 20 g/L.[3] Administration usually takes from fifteen to thirty minutes[3] and is done by a medical professional. Often, saline solution is mixed with the iron sucrose during injection.[7]

    Once iron sucrose has been administered, it is transferred to ferritin, the normal iron storage protein.[8] Then, it is broken down in the liver, spleen, and bone marrow. The iron is then either stored for later use in the body or taken up by plasma. The plasma transfers the iron to hemoglobin, where it can begin increasing red blood cell production.[3]

    Dosage

    It may be given at a dose of 100 mg with each session of dialysis for a total of 10 doses.[1]

    Iron sucrose is most commonly used to treat iron deficiency anemia, which can be caused by chronic kidney disease.[3]

    • Peristomal ulceration and redness persisted nearly 10 years despite conventional therapy.
      Peristomal ulceration and redness persisted nearly 10 years despite conventional therapy.
    • After 6 parenteral iron sucrose infusions, the wounds healed.
      After 6 parenteral iron sucrose infusions, the wounds healed.

    Side effects

    Iron sucrose can have a multitude of unintended side effects during and after administration. The following symptoms are considered serious, and a patient experiencing them should seek immediate medical attention:

    • headache
    • blurry vision
    • lasting dizziness or faintness
    • fever
    • chest pain or tightness
    • difficulty breathing
    • unusual heartbeat
    • unusual tingling
    • sudden weight change
    • swelling and bloating

    Less serious symptoms, which only need to be addressed by a medical professional if they are long-lasting, include:

    • sweetly-scented breath
    • difficulty tasting
    • nausea
    • eye pain, irritation, or swelling
    • diarrhea
    • pain at the injection site
    • body cramping, aching, pain, or weakness
    • issues moving
    • chills[9]

    Dizziness and fainting during treatment is not uncommon and can be addressed during treatment by a medical professional. These symptoms are also common when the dose the patient receives is raised.[10]

    Iron sucrose has also been shown to significantly lower the risk of gastrointestinal problems when compared to oral iron treatments. It has a much lower rate of serious allergic reactions in comparison to other iron substitution treatments (around 0.002% in iron sucrose in comparison to 0.04-2.3% in other treatments). In iron sucrose, there have been no reported cases of these reactions being deadly.[3]

    Chemisty

    Structure of iron sucrose. Sucrose molecule is black, and iron complex and ions in solution are red.

    The chemical formula of iron sucrose is C12H29Fe5Na2O23. The iron sucrose molecule is a polymer with two main molecules; sucrose (chemical formula C12H22O11) and an iron (III) hydroxide (Na2Fe5O8•3(H2O)). These two components are in solution together, but are not bound to one another.[11] Iron sucrose is a type II complex, with two oxygen atoms bonded to each iron atom.[3] When used for medicinal purposes, the iron complex is polymerized and the sucrose molecules combined to form a larger polysaccharide. The number of polymerizations does not have to be the same as the number of sucrose molecules in the polysaccharide.

    History

    Iron sucrose's first known use was in Europe in 1949,[2] but it was not used in US medicine until November 2000.[3] It replaced iron dextran, which had been in use in the US since the 1900s, as a treatment for iron deficiency. Iron dextran was only used for extremely high risk situations, because it released enough iron at once to be toxic to the body. Further development of iron dextran was able to lower these reactions, but also caused more severe gastrointestinal problems. These compounds caused issues mostly because of their high molecular weights. Low molecular weight alternatives were eventually introduced to counter these risks. The first of these was ferric gluconate in 1999, which lowered the risk of unwanted gastrointestinal issues. Iron sucrose followed shortly after, and had an even greater effect on reducing the frequency of serious adverse side effects.[3]

    References

    1. 1 2 3 4 5 6 7 8 9 "Iron Sucrose Monograph for Professionals". Drugs.com. Archived from the original on 12 August 2021. Retrieved 28 November 2021.
    2. 1 2 Auerbach M, Ballard H (2010-12-04). "Clinical use of intravenous iron: administration, efficacy, and safety". Hematology. American Society of Hematology. Education Program. 2010 (1): 338–47. doi:10.1182/asheducation-2010.1.338. PMID 21239816.
    3. 1 2 3 4 5 6 7 8 9 Cançado RD, Muñoz M (2011). "Intravenous iron therapy: how far have we come?". Revista Brasileira de Hematologia e Hemoterapia. 33 (6): 461–9. doi:10.5581/1516-8484.20110123. PMC 3459360. PMID 23049364.
    4. ↑ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1068. ISBN 978-0857114105.
    5. ↑ "Venofer Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 19 January 2021. Retrieved 28 November 2021.
    6. ↑ "Protocol for the use of Intravenous Iron Sucrose (Venofer ) - PDF". docplayer.net. Archived from the original on 2019-08-15. Retrieved 2019-05-23.
    7. ↑ "iron sucrose (injection)". Michigan Medicine. University of Michigan. Archived from the original on 2019-05-05. Retrieved 2019-05-05.
    8. ↑ Yee J, Besarab A (December 2002). "Iron sucrose: the oldest iron therapy becomes new". American Journal of Kidney Diseases. 40 (6): 1111–21. doi:10.1053/ajkd.2002.36853. PMID 12460028.
    9. ↑ "Iron Sucrose (Intravenous Route) Side Effects". Mayo Clinic. Archived from the original on 2019-04-20. Retrieved 2019-05-05.
    10. ↑ "Iron Sucrose (Intravenous Route) Description and Brand Names". Mayo Clinic. Archived from the original on 2019-04-20. Retrieved 2019-05-05.
    11. ↑ "Sucroferric oxyhydroxide". PubChem. National Center for Biotechnology Information, U.S. National Library of Medicine. Archived from the original on 2019-05-05. Retrieved 2019-05-05.
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