Mifepristone/misoprostol

Mifepristone/misoprostol
200 mg mifepristone (top) and 800 μg misoprostol (bottom), the typical regimen for early medical abortion
Combination of
MifepristoneProgesterone receptor antagonist
MisoprostolProstaglandin E1
Names
Trade namesMifegymiso,[1] Medabon Combipack[2]
Clinical data
Main usesBring about abortion[3]
Side effectsFever, upset stomach[4]
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Mifepristone/misoprostol are two medications packaged together and used to bring about medical abortion.[3] It is a common method of abortions before 12 weeks of pregnancy.[4] They are taken by mouth.[3]

Side effects may include mild fever and upset stomach.[4] It contains mifepristone, a progesterone receptor antagonist and misoprostol, a prostaglandin E1.[4]

Mifepristone came into use in France in 1987 and the United States in 2000.[5][6] It became available as a generic medication in 2019.[6] The combination is on the World Health Organization's List of Essential Medicines.[7] In the United States the medications can cost more than 500 USD as of 2023.[8][9]

Medical uses

Dosage

It is taken as mifepristone 200 mg by mouth, followed one to two days later by misoprostol 800 mcg under the tongue.[10]

References

  1. ↑ Linepharma International Limited (15 April 2019). "Mifegymiso Product Monograph" (PDF). Health Canada. Archived (PDF) from the original on 22 March 2023. Retrieved 10 September 2023.
  2. ↑ "Medabon - Combipack of Mifepristone 200 mg tablet and Misoprostol 4 x 0.2 mg vaginal tablets - Summary of Product Characteristics (SmPC)". Electronic Medicines Compendium (EMC). 3 February 2020. Archived from the original on 9 June 2021. Retrieved 19 January 2021.
  3. 1 2 3 "eEML - Electronic Essential Medicines List". list.essentialmeds.org. Archived from the original on 4 June 2023. Retrieved 8 September 2023.
  4. 1 2 3 4 Macnaughton, H; Nothnagle, M; Early, J (15 April 2021). "Mifepristone and Misoprostol for Early Pregnancy Loss and Medication Abortion". American family physician. 103 (8): 473–480. PMID 33856168.
  5. ↑ Corey, E.J. (2012). "Mifepristone". Molecules and Medicine. John Wiley & Sons. ISBN 9781118361733. Archived from the original on 2017-09-08.
  6. 1 2 Research, Center for Drug Evaluation and (24 March 2023). "Information about Mifepristone for Medical Termination of Pregnancy Through Ten Weeks Gestation". FDA. Archived from the original on 21 April 2023. Retrieved 10 September 2023.
  7. ↑ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
  8. ↑ "How Much Do Abortion Pills Cost?". GoodRx. Retrieved 10 September 2023.
  9. ↑ "How much does the abortion pill cost?". www.plannedparenthood.org. Archived from the original on 7 September 2023. Retrieved 10 September 2023.
  10. ↑ "Mifepristone and misoprostol: Recommended regimen". Ipas. Archived from the original on 22 April 2023. Retrieved 10 September 2023.
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