Bazedoxifene/conjugated estrogens
| Combination of | |
|---|---|
| Bazedoxifene | Selective estrogen receptor modulator |
| Conjugated estrogens | Estrogen |
| Names | |
| Trade names | Duavee, Duavive |
| Clinical data | |
| Main uses | Symptoms of menopause, osteoporosis after menopause[1] |
| Side effects | Muscle spasms, nausea, diarrhea, heart burn, dizziness, pain[1] |
| Pregnancy category | |
| Routes of use | By mouth |
| External links | |
| AHFS/Drugs.com | Monograph |
| US NLM | Bazedoxifene/conjugated estrogens |
| MedlinePlus | a614004 |
| Legal | |
| License data | |
| Legal status |
|
Bazedoxifene/conjugated estrogens, sold under the brand name Duavee and Duavive, is a combination medication used to treat symptoms of menopause and osteoporosis after menopause.[1] It is taken by mouth.[3] It should be used short term.[3]
Common side effects include muscle spasms, nausea, diarrhea, heart burn, dizziness, and pain.[1] Other side effects may include blood clots, stroke, and endometrial cancer.[1] It should not be used in pregnancy.[3] It contains bazedoxifene, a selective estrogen receptor modulator, and conjugated estrogens.[4]
The combination was approved for medical use in the United States in 2013 and Europe in 2014.[1][5] In the United States a month of medication costs about 180 USD as of 2022.[6]
Medical uses
Dosage
It is taken as one tablet of 0.45 mg conjugated estrogens and 20 mg bazedoxifene a day.[5]
Society and culture
Recall
In June 2020, Pfizer recalled two batches of Duavive, its oestrogen replacement product, as a result of concerns raised about faulty packaging.[7]
See also
References
- 1 2 3 4 5 6 "Selective Estrogen Receptor Modulators". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 11 January 2022. Retrieved 8 January 2022.
- 1 2 "Bazedoxifene / conjugated estrogens (Duavee) Use During Pregnancy". Drugs.com. 16 February 2019. Archived from the original on 26 June 2020. Retrieved 23 June 2020.
- 1 2 3 "DailyMed - DUAVEE- conjugated estrogens/bazedoxifene tablet, film coated". dailymed.nlm.nih.gov. Archived from the original on 10 May 2021. Retrieved 8 January 2022.
- ↑ "Bazedoxifene Monograph for Professionals". Drugs.com. Archived from the original on 19 April 2021. Retrieved 8 January 2022.
- 1 2 "Duavive EPAR". European Medicines Agency (EMA). Archived from the original on 2020-06-10. Retrieved 2020-06-10.
- ↑ "Conjugated Estrogens and Bazedoxifene Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 16 April 2016. Retrieved 8 January 2022.
- ↑ "Pfizer recalls 2 batches of Duavive". Zenopa. Archived from the original on 2020-09-27.
External links
| Identifiers: |
|---|
- "Bazedoxifene mixture with conjugated estrogens". Drug Information Portal. U.S. National Library of Medicine. Archived from the original on 2020-06-26. Retrieved 2021-05-07.