Andy Roddick

Roddick considered quitting competitive tennis at age 17 when he had a losing streak in the juniors. His coach Tarik Benhabiles talked him into giving tennis four more months of undivided attention. Roddick finished as the No. 6 junior in the U.S. in 1999, and as the No. 1 junior in the world in 2000. He won six world junior singles titles and seven world junior doubles titles, and won the US Open and Australian Open junior singles titles in 2000.[9]

In March in Miami, in the first round, Roddick had his first ATP level victory as he beat No. 41 Fernando Vicente of Spain, 6–4, 6–0. In August in Washington, D.C., he beat No. 30 Fabrice Santoro of France, 4–6, 6–3, 6–3. Roddick played the Banana Bowl in the city of São Paulo and won, beating Joachim Johansson in the final.[10] Roddick also won the Australian Junior Open, defeating Mario Ančić in the final.

Entering the pros in 2001 at the age of 18, Roddick quickly showed his promise when he defeated 7-time Wimbledon champion and world No. 4 Pete Sampras in the third round of the Miami Masters 7–6, 6–3.[11] Later that year, he dispatched then World No. 1 Gustavo Kuerten of Brazil, 6–7, 6–4, 6–2, in August.[12] Earlier, at the 2001 French Open, Roddick defeated a French Open champion, Michael Chang, in a five set battle 5–7, 6–3, 6–4, 6–7⁽⁵⁾, 7–5 in the second round. During the ensuing Wimbledon, he further showed potential by taking a set from eventual winner Goran Ivanišević.

Roddick's breakthrough year was 2003, in which he defeated Younes El Aynaoui in the quarterfinals of the 2003 Australian Open. Roddick and the Moroccan battled for five hours, with the fifth set (21–19 in favor of Roddick) at the time the longest fifth set in a Grand Slam tournament during the open era, at 2 hours and 23 minutes. Despite a lackluster French Open, Roddick enjoyed success in the United Kingdom by winning Queen's Club, beating No. 2 Andre Agassi, 6–1, 6–7, 7–6, along the way, and reaching the Wimbledon semifinals, where he lost to eventual champion Roger Federer in straight sets. He avenged that loss in August, beating then No. 3 Federer in Montreal, 6–4, 3–6, 7–6.[13] It is one of three times that Roddick defeated Federer in an official ATP tournament.

Roddick's hard-court record in 2003 included his first Masters Series titles—coming at Canada and Cincinnati—and his only Grand Slam title. At the 2003 US Open, Roddick rallied from two sets down and a match point in the semifinals to beat David Nalbandian of Argentina, 6–7, 3–6, 7–6, 6–1, 6–3. He then defeated No. 3 Juan Carlos Ferrero in the final, 6–3, 7–6, 6–3. At the Tennis Masters Cup in Houston, he defeated No. 7 Carlos Moyá of Spain, and No. 4 Guillermo Coria of Argentina, before losing to Roger Federer in the semifinals. By the end of the year, at age 21, he was ranked No. 1, the first American to finish a year at No. 1 since Andre Agassi in 1999. He also became the youngest American to hold this rank since computer rankings were started in 1973.

Roddick's reign at No. 1 ended the following February, when Roger Federer ascended to the top position, after winning his first Australian Open; the 2004 Australian Open would be the only time in Roddick's career that he was the No. 1 seed in a Grand Slam. In April, Roddick again beat No. 6 Moyá. In June, Roddick advanced to his first Wimbledon final after taking the first set from defending champion Federer, losing in four sets. Roddick was knocked out during the 2004 US Open in a five-set quarterfinal against another big server, Joachim Johansson. In September, he beat No. 9 Marat Safin of Russia in Bangkok. At the 2004 Summer Olympics, Roddick lost to Chilean Fernando González, the eventual bronze medal winner, in the third round. In November he beat No. 7 Tim Henman of Great Britain, No. 4 Safin, and No. 6 Guillermo Coria. Later that year, Roddick teamed up with Mardy Fish and Bob and Mike Bryan on the U.S. Davis Cup team that lost to Spain in the final in Seville. Roddick lost his singles match against Rafael Nadal, who would in the following year win the French Open. Towards the end of 2004, Roddick fired his coach of 18 months, Brad Gilbert, and hired assistant Davis Cup coach Dean Goldfine. Roddick finished 2004 ranked as the world No. 2, U.S. No. 1, and player with the most aces (2,017). In 2004, Roddick saved fellow tennis player Sjeng Schalken and other guests (including close friends Ben Campezi and Dean Monroe) from a hotel fire.[14]

Roddick on his way to the first tournament win of 2005

Roddick's first 2005 tournament victory was the SAP Open in San Jose, California, where he became the first to win the event in consecutive years since Mark Philippoussis in 1999 and 2000. The top-seeded Roddick defeated Cyril Saulnier in 50 minutes, the event's first championship shutout set since Arthur Ashe beat Guillermo Vilas in 1975. In March, he defeated No. 7 Carlos Moyá. In April, Roddick won the U.S. Men's Claycourt Championships, reclaiming the title he won in 2001 and 2002. (He lost in 2003 to Agassi, and in 2004 to Tommy Haas.) At the Rome Masters in May, Roddick had match point in the round of 16 against Spain's Fernando Verdasco. Verdasco was attempting to save the match point on his second serve, when the linesman erroneously called the serve out. If this call had held, Roddick would have won the match. Roddick motioned to the umpire, pointing to the clear ball mark on the clay indicating that the ball was in, and the call was consequently changed. Verdasco went on to win the match. At the 2005 French Open, Roddick lost to unseeded Argentine José Acasuso in the second round, and at Wimbledon, Roddick lost to Federer in the final for the second consecutive year. In August, he defeated No. 3 Lleyton Hewitt at the Masters Series tournament in Cincinnati. At the US Open, Roddick was defeated by No. 70 Gilles Müller in the first round. Roddick's most recent US Open first-round loss had been in 2000. At the Grand Prix de Tennis de Lyon, Roddick defeated Gaël Monfils to wrap up a tournament without losing a set or getting his serve broken.

Roddick's first ATP event of the year was the Australian Open. There, he reached the fourth round, before being upset by unseeded and eventual finalist, Marcos Baghdatis. At the French Open, Roddick retired in the first round, after sustaining a foot injury during the match. Two weeks later at Wimbledon, Roddick was upset in the third round by British hopeful Andy Murray. This loss caused Roddick to fall below the top 10 for the first time since 2002. After Wimbledon, Roddick began working with a new coach, tennis legend Jimmy Connors. In his first event with his new coach, Roddick reached the final of Indianapolis, before losing to good friend and fellow American, James Blake. His resurgence finally came at the Cincinnati Masters, where he won the event by defeating Juan Carlos Ferrero in the final, making this the first masters event he won since 2004. At the US Open, Roddick easily won his first two matches against Florent Serra and Kristian Pless. He then played a thriller five-set match against Fernando Verdasco, winning 6–2 in the final set. Next, he beat Benjamin Becker, who was coming off a huge win against recently retired Andre Agassi. In the quarterfinals, Roddick beat Lleyton Hewitt, avenging his loss in 2001, 6–3, 7–5, 6–4. Now in the semifinals for the first time since he won in 2003, Roddick played Mikhail Youzhny and beat him, 6–7, 6–0, 7–6, 6–3. In the finals of a Grand Slam for the first time since Wimbledon a year prior, Roddick played No. 1 Federer. He lost, however, 2–6, 6–4, 5–7, 1–6. He then qualified for the year-ending Tennis Masters Cup, where he defeated No. 4 Ivan Ljubičić of Croatia, 6–4, 6–7, 6–1, but lost in the round robin to No. 1 Federer, 6–4, 6–7, 4–6, in a tough three-set battle, despite holding three match points in the second-set tiebreaker.

Roddick entered the 2007 Australian Open as the sixth seed. In his first-round match, he lost a marathon first-set tiebreak 20–18, but eventually won the match in four sets against wild card Jo-Wilfried Tsonga from France. Roddick defeated 26th-seeded Marat Safin in the third round, and ninth-seeded Mario Ančić in a five-set fourth-round match. Roddick won his quarterfinal match against fellow American Mardy Fish. His run was ended in the semifinals by No. 1 Federer, who defeated him in straight sets, making his head-to-head record against Federer 1–13. In first-round Davis Cup action, Roddick helped the US defeat the Czech Republic, winning his singles matches against Ivo Minář and Tomáš Berdych. Roddick reached at least the semifinals of his next two tournaments. He bowed out to Andy Murray in the semifinals of the SAP Open in San Jose, California, a reprise of 2006. Roddick then defeated Murray in the semifinals of the Regions Morgan Keegan Championships and the Cellular South Cup in Memphis, Tennessee, before losing in the final to defending champion Tommy Haas. Reaching the final, however, enabled Roddick to overtake Nikolay Davydenko for the No. 3 position, his first week inside the top three since March 6, 2006. At the first ATP Masters Series tournament of the year, after beating No. 8 Ivan Ljubičić, Roddick reached the semifinals of the Pacific Life Open in Indian Wells, California, but lost to No. 2 Rafael Nadal.

Roddick then played the Miami Masters, where he gave up in his quarterfinal match against Andy Murray due to a left hamstring injury. Roddick then helped the U.S. defeat Spain and advance to the Davis Cup semifinals, winning his lone singles match against Fernando Verdasco. However, Roddick re-aggravated his hamstring injury during the Davis Cup tie, and was subsequently forced to pull out of the U.S. Men's Clay Court Championships in Houston, Texas. Roddick also announced that he would withdraw from the Monte Carlo Masters, citing the injury. His next tournament was the Internazionali d'Italia. After a first-round bye, he won his first match against Gastón Gaudio, where he saved three break points and fired nine aces. However, he was unable to stop Juan Ignacio Chela in the third round. Roddick then withdrew from the Masters Series Hamburg tournament because, according to his website, he needed time to physically prepare himself for the upcoming French Open. Roddick was seeded third at the French Open, but was eliminated in the first round by Russian Igor Andreev in four sets. Roddick was victorious at the Stella Artois Championships for the fourth time, when he defeated Nicolas Mahut in the final. At Wimbledon, Roddick was seeded third and considered one of the pre-tournament favorites behind Federer and Nadal. He reached the quarterfinals after wins against Justin Gimelstob of the U.S., Danai Udomchoke of Thailand, Fernando Verdasco of Spain, and Paul-Henri Mathieu of France. In the quarterfinals, Roddick lost in five close sets to Richard Gasquet of France.

Roddick in Washington, 2007

During the summer hard-court season, Roddick played four tournaments in four weeks. Roddick made it to the semifinals of the Indianapolis Tennis Championships, where he was upset by Frank Dancevic of Canada. The next week, however, Roddick claimed his second ATP title of the year by winning the Legg Mason Tennis Classic in Washington, D.C. for the third time, when he beat American newcomer John Isner. He then lost in the quarterfinals of the Rogers Cup in Montreal to Novak Djokovic, and in the third round of the Western & Southern Financial Group Masters tournament in Cincinnati to David Ferrer of Spain. At the US Open, Roddick defeated Gimelstob in the first round. He won his next three matches, one in straight sets and the other two when his opponent retired. In the quarterfinals, Roddick once again lost to Federer, bringing his head-to-head record with Federer 1–14. There were no breaks of serve and only one break point total in the first two sets, that being on Federer's serve.

Roddick then set his sights on the Madrid Masters, but pulled out, citing a knee injury. At his next tournament two weeks later in Lyon, France, Roddick lost in the first round to Frenchman Fabrice Santoro. Roddick then withdrew from the Paris Masters, incurring a $22,600 fine for not fulfilling his media obligations at the tournament.[15] At the season-ending Tennis Masters Cup in Shanghai, Roddick defeated No. 4 Nikolay Davydenko in his first round-robin match, and then defeated No. 7 Fernando González in his next match to become the first player to qualify for the semifinals of the tournament. In his third and final round-robin match, Roddick lost once again to Federer for the 15th time in 16 career matches. In the semifinals, Roddick lost to sixth seed David Ferrer, who had won all three of his round-robin matches. This was Roddick's third semifinal finish in five years at the Tennis Masters Cup (he reached the semifinals in 2003 and 2004, withdrew in 2005, and failed to advance to the semifinals in 2006 after a 1–2 round-robin record). Roddick finished the year by helping the U.S. defeat Russia and win the 2007 Davis Cup, its 32nd Davis Cup victory, but first since 1995. Roddick won his rubber against Dmitry Tursunov, before James Blake and Bob and Mike Bryan completed the victory. Having secured the tie with an unassailable 3–0 lead, Roddick decided to sit out his second singles rubber of the tie.

Roddick started 2008 strongly, defeating Ivan Ljubičić and Safin to reach the AAMI Kooyong Classic final for the fourth consecutive season. In the final, he defeated Marcos Baghdatis to win the tournament for the third consecutive year. Roddick was seeded sixth in the 2008 Australian Open. In the first round, he defeated Lukáš Dlouhý of the Czech Republic. In the second round, he defeated German Michael Berrer in straight sets. He then lost to the 29th seed Philipp Kohlschreiber of Germany in the third round in a five-set match. Despite losing, Roddick served a career-high of 42 aces in the match. Roddick won his 24th career title and his third title of the year at the SAP Open in San Jose, California, defeating Czech Radek Štěpánek in straight sets. Roddick's next tournament was the Dubai Tennis Championships. He made it to the semifinals by defeating No. 2 Rafael Nadal of Spain, his first victory over Nadal since the second round of the 2004 US Open. The win also marked Roddick's first victory over a player ranked in the top two since June 2003. He progressed through to the final by defeating No. 3 and 2008 Australian Open singles champion Novak Djokovic in the semifinal. By making it to the final, he became the first American to reach the Barclays Dubai Tennis Championships final in the tournament's 16-year history. In the final he defeated Feliciano López to win his 25th career title. He never lost his serve during the entire tournament.

Following Roddick's quarterfinal match in Dubai, he announced that he had split with his coach of two years, Jimmy Connors. Connors had resigned a week earlier, saying he wanted to spend more time with his family.[16] Roddick would continue to be coached by his brother, John Roddick. He then fell to No. 2 Tommy Haas at the Pacific Life Open in the second round. At the 2008 Sony Ericsson Open, Roddick advanced to the semifinals after defeating No. 1 Roger Federer an hour after proposing to Brooklyn Decker, bringing his head-to-head record against Federer to 2–15. Roddick improved to 3–0 against top-3 players in 2008. Roddick lost in the semifinals to Nikolay Davydenko. Roddick's next tournament was the Masters tournament in Rome. There, he equaled his best result by reaching the semifinals, where he retired against Stanislas Wawrinka in the pair's first encounter, due to a back injury.

Roddick was forced to pull out of the French Open due to a shoulder injury. After a visit to a doctor in New York, it was determined this was nothing more than an inflammation of the rotator cuff. His first tournament after the shoulder injury was the Artois Championship, his annual Wimbledon preparation, where he was the defending champion. Roddick defeated Mardy Fish and Andy Murray, before losing to eventual champion Rafael Nadal in the semifinals. At Wimbledon, Roddick was beaten by Serbia's Janko Tipsarević in the second round. This was his earliest exit at Wimbledon. Roddick was beaten at the Rogers Cup in the third round by Marin Čilić. He was then forced to pull out of the Cincinnati Masters following a neck injury, which he said may have been caused by a poor sleeping posture. He stated in an interview that the neck injury had nothing to do with his shoulder injury. Roddick did not participate in the 2008 Summer Olympics, but chose to concentrate on the US Open.[17] Roddick then played in the smaller hard-court tournaments in the US Open Series, including those at Los Angeles and Washington, D.C. At the Countrywide Classic in Los Angeles, Roddick lost to Juan Martín del Potro in the final.

At the US Open, Roddick defeated Fabrice Santoro in the first round. Roddick then won his next three matches against Ernests Gulbis, Andreas Seppi, and Fernando González. In the quarterfinals, Roddick lost to No. 3 Novak Djokovic, bringing his head-to-head record with Djokovic to 1–2.

Capturing the 26th title of his career in China, 2008

Roddick captured his 26th ATP title in Beijing at the China Open in September. He defeated Dudi Sela of Israel in the final. In the third round of the Madrid Masters, he lost to Gaël Monfils in three sets. Two weeks later, Roddick reached the quarterfinals of the Paris Masters by defeating Gilles Simon, before losing to Jo-Wilfried Tsonga. Due to his performance in the tournament, Roddick qualified for the season-ending Tennis Masters Cup. At the Masters Cup in Shanghai, he played Andy Murray in his first round-robin match and lost. He was then scheduled to play Roger Federer, but retired due to an ankle injury and was replaced by Radek Štěpánek.

Roddick hired Larry Stefanki as his new coach and started working with him on December 1, 2008. Stefanki had previously trained John McEnroe, Marcelo Ríos, Yevgeny Kafelnikov, Fernando González, and Tim Henman. Under Stefanki's guidance, both Rios and Kafelnikov rose to the world No. 1 ranking, and Henman and González reached the top five, including a 2007 Australian Open runner-up finish by Gonzalez. Roddick began official tournament competition at the Qatar ExxonMobil Open. He defeated Gaël Monfils in the semifinals, before losing to Andy Murray in the final. At the 2009 Australian Open, Roddick defeated Xavier Malisse in the second round. After victories over Fabrice Santoro and 21st-seeded Tommy Robredo, Roddick played the defending champion and No. 3 Novak Djokovic in the quarterfinals. Djokovic retired in the fourth set while trailing, which allowed Roddick to reach the fourth Australian Open semifinal of his career. Roddick was defeated there by eventual runner-up Roger Federer in straight sets.

Roddick reached the fourth round of the French Open for the first time.

His next tournament was the SAP Open. He snapped a three-match losing streak against Tommy Haas in the quarterfinals, before losing in the semifinals to Radek Štěpánek for the first time in his career. At the Regions Morgan Keegan Championships, Roddick defeated Australian Lleyton Hewitt in the semifinals to reach the final. He took his first title of the year by beating Štěpánek in the final. Roddick chose not to defend his Dubai title, with prize money of $2 million, to protest the refusal of the United Arab Emirates to grant Israeli Shahar Pe'er a visa for the Women's Tennis Association event.[18][19] "I really didn't agree with what went on over there", Roddick said.[18][19] Roddick played both of the spring ATP World Tour Masters 1000 events in the U.S. He was seeded seventh at the BNP Paribas Open in Indian Wells. He defeated defending champion Novak Djokovic in the quarterfinals. His run was ended by No. 1 Rafael Nadal in the semifinals. However, he won the doubles title with partner Mardy Fish. It was his fourth doubles title overall and his second partnering Fish. At the Miami Masters, Roddick beat ninth seed Gaël Monfils in the fourth round to secure a place in the quarterfinals, where he lost to Roger Federer.

After a break from tournament tennis to get married, Roddick returned to action at the ATP World Tour Masters 1000 clay-court event in Madrid. In his first match, Roddick survived two match points in the second-set tiebreaker to defeat Tommy Haas. In the quarterfinals, Roddick again lost to Federer. Roddick had his career-best result at the French Open, when he defeated Marc Gicquel in the third round. He lost in the fourth round to Monfils.

A twisted ankle forced Roddick to retire from his semifinal match against James Blake at 4–4 during the Aegon Championships, his first grass-court tournament that year. He was seeded sixth at Wimbledon. Roddick defeated Lleyton Hewitt in the quarterfinals, serving a career-high of 43 aces, and third-seeded Andy Murray in the semifinals.[20] He then lost to Federer for the third time in a Wimbledon final with a fifth set reaching 14–16, and he was praised for his performance.[21] Even though Roddick lost this match, he set a record for number of games won in a Wimbledon final at 39. This was his fourth meeting with Federer in a Grand Slam final, all won by Federer. The match set records for the longest men's Grand Slam final in history at 77 games and fifth set in a men's Grand Slam final.[22] Following the match, when asked to elaborate on his marathon performance, Roddick replied, "I lost."[23] On the strength of his Wimbledon performance, Roddick returned to the top five on July 13, 2009.

Roddick reached the final of Wimbledon but had a disappointing US Open.

Roddick returned to action as the top seed at the Legg Mason Tennis Classic. He defeated Benjamin Becker, and then Sam Querrey. He defeated Ivo Karlović in the quarterfinals, and John Isner in the semifinals. In the final, he lost to defending champion Juan Martín del Potro, despite saving three match points. Roddick played the next week at the ATP World Tour 1000 event in Rogers Cup, where he was seeded fifth. He defeated Igor Andreev, then No. 11 Fernando Verdasco, and in the quarterfinals defeated No. 4 Novak Djokovic, improving his career record against Djokovic to 4–2 (3–0 in 2009). He then lost to No. 6 Juan Martín del Potro in the semifinals, despite having a match point. The loss dropped his career record against del Potro to 0–3 (0–2 in 2009). Roddick next played at the ATP World Tour 1000 event in Cincinnati, where he was seeded fifth. He lost to Sam Querrey in his first match, after having received a bye in the first round. Roddick entered the US Open as the fifth seed. In his first-round match, he defeated the German veteran Björn Phau. He then faced Frenchman Marc Gicquel as his parents and newlywed wife watched from the stands. In the third round, he was eliminated by fellow American John Isner. He lost his serve only once during the match, as was the case in the Wimbledon final.

Roddick's next tournament was the 2009 China Open in Beijing, where he was the defending champion. In a shocking upset, he was defeated in the first round by Polish qualifier and No. 143 Łukasz Kubot. He also played doubles at the event with Mark Knowles. The pair reached the final, losing to Bob and Mike Bryan. Roddick was forced to retire from his first-round match at the 2009 Shanghai Masters against Stanislas Wawrinka while leading 4–3. It was later announced that Roddick would return to the United States to seek medical advice on a left-knee injury.[24] Once again, he qualified for the Year-End Masters in London, securing the sixth spot. However, Roddick withdrew from the 2009 Valencia Open 500, the 2009 BNP Paribas Masters, and the 2009 Barclays ATP World Tour Finals due to the injury he suffered at the Shanghai Masters. He finished 2009 as the No. 7 in the world.

Andy Roddick playing at Australian Open 2010

Roddick started his 2010 campaign at the Brisbane International as the top seed. In the final, Roddick defeated defending champion Radek Štěpánek for his first ATP Tour title since February 2009, and making 2010 his tenth consecutive season with at least one ATP singles title. Roddick teamed with James Blake in the men's doubles and made it to the semifinals, before losing to eventual champions Jérémy Chardy and Marc Gicquel. Roddick announced that he would not represent the United States in Davis Cup competition for the 2010 season. Roddick entered the Australian Open as the seventh seed. He lost in the quarterfinals to Marin Čilić, despite coming back from two sets down while battling an apparent shoulder injury.[25]

He then played in the SAP Open. In the semifinals, he lost the first set 2–6 to Sam Querrey, but came back winning the final two sets in tie-breaks and went to the final, where he lost to Fernando Verdasco. He then entered the Regions Morgan Keegan Championships, where he lost in the quarterfinals in a rematch of the San Jose semifinals to Sam Querrey. Playing in the BNP Paribas Open at Indian Wells, Roddick went to the semifinals, where he faced Robin Söderling, and despite a 0–2 record against him, won. Roddick lost to Ivan Ljubičić in the final. This was Roddick's first Masters Series final since the 2006 Cincinnati Masters. In the Sony Ericsson Open, Roddick defeated Igor Andreev, Sergiy Stakhovsky, Benjamin Becker, and Nicolás Almagro. In the semifinals he upset fourth-seed Rafael Nadal to reach his fourth final of the year. In the final, Roddick won his second Sony Ericsson Open title, after defeating Tomáš Berdych in straight sets. This was Roddick's 29th title in 49 finals, fifth ATP Masters 1000 title, and first Masters 1000 title since 2006.

Roddick did not fare well during the clay-court season, withdrawing from Rome due for personal reasons and from Madrid due to a stomach virus. Roddick then lost in the third round of the French Open to Teymuraz Gabashvili in straight sets. Failure at Roland Garros was followed by another disappointment when Roddick suffered his earliest ever exit in the 2010 Aegon Championships, a grass-court Wimbledon tune-up event. He was beaten by Dudi Sela in the third round. At Wimbledon, Roddick was seeded fifth, which was two spots higher than his ATP ranking of seven. He was defeated in the fourth round by No. 82 Lu Yen-hsun of Taiwan in five sets. Like his final match with Roger Federer the previous year, his serve was broken only once during the match, in the fifth set.

Andy Roddick playing at US Open 2010

Roddick next took a wild card to play in the Atlanta Tennis Championships, the first event of the US Open Series, where he was the top seed. He was eliminated in the semifinals by eventual champion Mardy Fish. His next tournament was the Legg Mason Tennis Classic, where he lost in the round of 16 to Gilles Simon. The only American man in the ATP top 10 prior to the tournament, the loss dropped him from the list. For the first time since the inception of the ATP world rankings, there was no American man in the top 10. Following the Washington tournament, Roddick withdrew from the Canada Masters due to illness, leading to a drop in ranking to No. 13, his lowest ranking since 2002. On August 14, 2010, Roddick revealed that he had been diagnosed with mononucleosis, although he said his doctor believed it was in its later stages and he would make a complete recovery soon.[26] At the Cincinnati Masters, he defeated No. 5 Robin Söderling to reach the quarterfinals, where he defeated second seed Novak Djokovic. The win was Roddick's fourth consecutive over Djokovic, raising his career head-to-head record against Djokovic to 5–2 and ensuring Roddick's return to the top 10. In the semifinals, Roddick faced Mardy Fish, but lost, failing to serve out the match at 5–3 in the second set. In the second round of the US Open, Roddick was beaten by Janko Tipsarević of Serbia in four sets.

He then played at the Rakuten Japan Open Tennis Championships, but lost in the semifinals to Gaël Monfils. Roddick was seeded tenth at the Shanghai Rolex Masters. In the first round, Roddick defeated Philipp Kohlschreiber after Kohlschreiber retired in the second set down 3–6, 1–2. Roddick second-round opponent was Guillermo García-López. Leading 6–3, 2–3, Roddick suffered a groin injury and was forced to retire from the match. At the Davidoff Swiss Indoors in Basel, Roddick was seeded fourth. He defeated Sam Querrey, Andrey Golubev, and David Nalbandian, earning a semifinal match against Roger Federer, their first meeting since the 2009 Wimbledon final. He lost to Federer in straight sets.

At the BNP Paribas Masters, Roddick was the eighth seed and received a bye in the first round. He advanced to the quarterfinals with wins over Jarkko Nieminen and Ernests Gulbis in the second and third round, respectively. Roddick then fell to No. 5 Robin Söderling. With Fernando Verdasco failing to reach the final, Roddick automatically qualified for the Barclays ATP World Tour Finals for the eighth consecutive year. Though he had dropped out of the top 10 in the ATP rankings after his early exit from the US Open, his victory over Gulbis in Paris assured his return to the top 10 at year end, making him and Federer the only players to maintain year-end top-10 ATP rankings from 2002 through 2010. Roddick played his final tournament of the year at the Barclays ATP World Tour Finals. Roddick was placed in Group A with Rafael Nadal, Novak Djokovic, and Tomáš Berdych. In the tournament Roddick lost all of his round-robin matches. Roddick ended the year No. 8, his ninth consecutive season finishing in the top 10.

Roddick began his 2011 campaign in the Brisbane International as the second seed and the defending champion, where he was defeated by top seed Robin Söderling in the final. At the Australian Open, Roddick was the eighth seed. In the fourth round, Roddick lost to Stanislas Wawrinka in straight sets. He then won the 2011 Regions Morgan Keegan Championships, defeating Milos Raonic, after defeating Ričardas Berankis, Janko Tipsarević, Lleyton Hewitt, and Juan Martín del Potro. Roddick began his Davis Cup campaign for the United States against Chile. He faced Nicolás Massú in the opener and defeated him in four sets. He then faced Paul Capdeville to clinch the victory for the U.S., and he did so by winning in four sets. Roddick improved his record to 12–0 in Davis Cup clinchers.

At the BNP Paribas Open, he was beaten by Richard Gasquet in the fourth round. In the 2011 Sony Ericsson Open, as the defending champion, Roddick was upset by Pablo Cuevas in the second round. This loss dropped Roddick to No. 12 in the rankings and the second-ranked American behind compatriot Mardy Fish. Roddick then began his clay-court season at the Mutua Madrid Open, but he was upset in the first round by Italian qualifier Flavio Cipolla in three sets. Roddick continued to warm up for the 2011 French Open in Italy, playing the Internazionali BNL d'Italia, but lost in the first round for the second straight tournament to Gilles Simon. He teamed with Mardy Fish to play doubles in Rome, and they went to the final before Roddick had to withdraw because of a shoulder injury. Roddick also withdrew from the Nice Open in France and pulled out of the 2011 French Open, after failing to recover.

Andy Roddick at the Queen's Championships

Roddick returned to action at the Aegon Championships, where he was a four-time champion. In the semifinals, he played Andy Murray, their first meeting since the Wimbledon 2009 semifinals, but Roddick was defeated in straight sets. Roddick was seeded eighth for Wimbledon, and in the first round, he beat Andreas Beck of Germany in straight sets. In the second round, Roddick defeated Victor Hănescu, again in straight sets. In the third round, Roddick was beaten in straight sets by left-handed Spaniard Feliciano López. The upset loss to Lopez meant that Roddick failed to reach the quarterfinals of any Grand Slam since the 2010 Australian open. This was the longest Roddick had ever gone in his career without reaching the quarterfinals of a Grand Slam. In the Davis Cup quarterfinals match against Spain, Roddick drew David Ferrer first, but lost in three tight sets. Roddick was supposed to play Feliciano López in reverse singles, but after David Ferrer wrapped up the victory for Spain by defeating Mardy Fish, their match was cancelled.

Roddick withdrew from the Legg Masson Tennis Classic, and Rogers Cup, after partially tearing his oblique muscle while practicing. He returned to action after a couple of weeks' rest from his injury and played at the Western & Southern Open. He lost in the first round to Philipp Kohlschreiber. This loss made him drop out of the top 20 for the first time since August 2001. After suffering an early exit at Cincinnati, Roddick played at the Winston-Salem Open in North Carolina, where he was the top seed after the withdrawal of the top-ranked American Mardy Fish. Roddick lost in the semifinals to John Isner. Roddick was seeded 21st at the U.S. Open. He began his campaign with a four-set win over fellow American Michael Russell. He then defeated another American Jack Sock in straight sets. In the third round, he defeated Julien Benneteau, also in straight sets. He then backed it up with a four-set win over David Ferrer to advance to his first Grand Slam quarterfinal since the 2010 Australian Open. He eventually fell to No. 2 Rafael Nadal.

After this, he played at the China Open, where he lost to Kevin Anderson. Still in China, his next tournament was the Shanghai Rolex Masters, where he fell to Spaniard David Ferrer in the quarterfinals. After this, he played at the Swiss Indoors Basel, where he lost to Roger Federer in the quarterfinals. Going straight to Paris for the BNP Paribas Masters, he had a third-round loss to Andy Murray. This loss ended Roddick's 2011 season, which left him out of the top 10, after being there for nine consecutive years.

Roddick began his 2012 season at the 2012 Australian Open. In the first round, he beat Robin Haase in straight sets. In the second round, he was forced to retire against Australian Lleyton Hewitt while trailing, due to a hamstring injury. Following the injury, Roddick entered the SAP Open in San Jose, California. He beat Denis Kudla in the round of 16, but lost in the quarterfinals to Denis Istomin. Roddick traveled to Memphis to defend his title at the Regions Morgan Keegan Championships. His title defense was short-lived though, as he dropped his first-round match to Xavier Malisse. After the disappointment in Memphis, Roddick entered the Delray Beach International Tennis Championships, where he defeated Philipp Petzschner and Istomin in the first and second rounds, respectively, before falling to Kevin Anderson.

Andy Roddick at the Queen's Championships 2012 with Hewitt

In March, Roddick entered the first Masters 1000 event of the season at Indian Wells, where he received a first-round bye. He beat Łukasz Kubot in the second round, but then lost in the next round to No. 7 Tomáš Berdych. Later in the month, Roddick had better results at the Sony Ericsson Open, where he beat Gilles Müller in the second round. That win set up a third-round match with No. 3 Federer, this being the first time they played each other before the quarterfinals of any tournament. Roddick defeated Federer for only the third time in his career to reach the fourth round, but then lost to Juan Mónaco from Argentina. Roddick then elected not to play in the final three clay-court Masters events leading up to the French Open. At French Open, he fell to Nicolas Mahut in the first round in four sets. After this, Roddick played at Aegon Championships, where he lost in the second round to Édouard Roger-Vasselin, despite having a match point in the third set.

Roddick's next tournament was the Aegon International, where he received a wild card into the main draw as the sixth seed. In the first round, he led countryman Sam Querrey 5–2 in the first set when Querrey retired injured. Roddick then beat Jérémy Chardy and Fabio Fognini to set up a semifinal with qualifier Steve Darcis, which Roddick led 6–3, 3–1 when Darcis retired. Roddick then proceeded to defeat defending champion Andreas Seppi in the final for his 31st career title and first of 2012.[27] He thus became the only male tennis player besides Roger Federer to have won at least one title every year in the past 12 years. Roddick began his Wimbledon campaign with a first-round match against British wild-card entrant Jamie Baker. He beat German qualifier Björn Phau in the second round in straight sets. He lost to David Ferrer in the third round in four sets.

Roddick started the US Open Series at the BB&T Atlanta Open. He took a bye into the second round and avenged his loss at the French Open by defeating Nicolas Mahut. He then defeated countryman Michael Russell in the quarterfinals and upset top seed John Isner in the semifinals. He went on to defeat Gilles Müller in the final.[28] Roddick's London Olympics campaign began with a victory over Martin Kližan. In the second round, Roddick lost to No. 2 Novak Djokovic.[29] After the Olympics, Roddick decided not to play in Toronto and went straight to Cincinnati, where he lost in the first round to Frenchman Jérémy Chardy.

In the US Open, Roddick began his campaign with a victory over his countryman Rhyne Williams. On August 30, 2012, which was his thirtieth birthday, Roddick announced that he would retire after the tournament.[30] After announcing his retirement, Roddick defeated Australian Bernard Tomic and Italian Fabio Fognini before his final match on September 5, 2012, where he lost to Argentine Juan Martín del Potro in four sets in the fourth round of the tournament. Four days after his loss, Roddick was honored in a special ceremony in Arthur Ashe Stadium on his retirement, in which Andre Agassi participated. Due to his retirement, he ended the year at No. 39, the lowest he had been since 2000, the year he turned professional, when he only played five events.

Roddick played one tournament on tour, the 2015 BB&T Atlanta Open, where he competed in the men's doubles event with Mardy Fish. They lost in the quarterfinals.

Roddick was inducted into the International Tennis Hall of Fame on July 22, 2017, alongside Kim Clijsters of Belgium.[31]

• These records were attained in the Open Era of tennis.

In 2011, Roddick made a cameo appearance in the Adam Sandler comedy film Just Go with It with his real-life wife Brooklyn Decker.[85]