CD164

Sialomucin core protein 24 also known as endolyn or CD164 (cluster of differentiation 164) is a protein that in humans is encoded by the CD164 gene.[5][6] CD164 functions as a cell adhesion molecule.

CD164
Identifiers
AliasesCD164, MGC-24, MUC-24, endolyn, DFNA66, CD164 molecule, MGC-24v
External IDsOMIM: 603356 MGI: 1859568 HomoloGene: 38129 GeneCards: CD164
Orthologs
SpeciesHumanMouse
Entrez

8763

53599

Ensembl

ENSG00000135535

ENSMUSG00000019818

UniProt

Q04900

Q9R0L9

RefSeq (mRNA)

NM_016898

RefSeq (protein)

NP_058594

Location (UCSC)Chr 6: 109.37 – 109.38 MbChr 10: 41.4 – 41.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sialomucins are a heterogeneous group of secreted or membrane-associated mucins that appear to play two key but opposing roles in vivo: first as cytoprotective or antiadhesive agents, and second as adhesion receptors. CD164 is a type I integral transmembrane sialomucin that functions as an adhesion receptor.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000135535 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000019818 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Watt SM, Bühring HJ, Rappold I, Chan JY, Lee-Prudhoe J, Jones T, Zannettino AC, Simmons PJ, Doyonnas R, Sheer D, Butler LH (August 1998). "CD164, a novel sialomucin on CD34(+) and erythroid subsets, is located on human chromosome 6q21". Blood. 92 (3): 849–66. doi:10.1182/blood.V92.3.849. PMID 9680353.
  6. Zannettino AC, Bühring HJ, Niutta S, Watt SM, Benton MA, Simmons PJ (October 1998). "The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as a potent negative regulator of hematopoiesis". Blood. 92 (8): 2613–28. doi:10.1182/blood.V92.8.2613. PMID 9763543.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.