Burkhard Rost

Burkhard Rost is a scientist leading the Department for Computational Biology & Bioinformatics at the Faculty of Informatics of the Technical University of Munich (TUM).[10] Rost chairs the Study Section Bioinformatics Munich involving the TUM and the Ludwig Maximilian University of Munich (LMU) in Munich. From 2007-2014 Rost was President of the International Society for Computational Biology (ISCB).[6][11][12][13][14][15][16]

Burkhard Rost
Burkhard Rost speaking at ISMB
Born (1961-07-11) July 11, 1961
Germany
Alma materUniversity of Heidelberg[1]
Known for
SpouseKarima Djabali[3]
AwardsAlexander von Humboldt Professor, ISCB Fellows Award[4]
Scientific career
Fields
Institutions
ThesisNeural networks and evolution - advanced prediction of protein secondary structure (1994)
Doctoral advisorChris Sander[1][9]
Websitewww.rostlab.org

Career

Rost originally started his scientific career as theoretical physicist. After studying physics at the University of Giessen and physics, history, philosophy, and psychology at the University of Heidelberg, Rost received his PhD at the University Heidelberg for his work at the European Molecular Biology Laboratory (EMBL) in 1994.[1] Following research internships at EMBL and the European Bioinformatics Institute in Cambridge (UK), in 1998, he became assistant professor at the Department of Biochemistry and Molecular Biophysics in the College of Surgeons and Physicians of the CU Medical Center of Columbia University in the City of New York. In 2000, he became associate professor at Columbia University and in 2009 he accepted an appointment to the Chair of Bioinformatics at the Technical University of Munich. He is a member of the New York Academy of Sciences and has been President of ISCB, the International Society for Computational Biology from 2007-2014. As of 2021, Rost has authored or co-authored over 300 scientific publications with a Google Scholar h-index of 100.[6][11][12][13]

Research

Rost research has focused on combining Machine Learning and evolutionary information to predict aspects of critical importance to advance our understanding of evolution, protein structure and protein function. Examples of research carried out in his lab includes the prediction of enzymatic activity (ECGO), interaction partners (ISIS, DISIS, PiNAT), subcellular localization (LOCtree, LOCnet, PredictNLS), functional effects of point mutations/SNPs (SNAP), disordered regions (MD, NORSnet, Ucon), membrane spanning segments (PROF/PHDhtm), secondary structure (PROF/PHD, RePROF, DSSPcont),[17] solvent accessibility (PROF/PHD, RePROF), internal residue-residue contacts (PROFcon) and the clustering of proteins into families (CHOP).[18]

His current focus is on predicting the effects of individual mutations mostly on the level of non-synonymous changes in coding regions, i.e. single nucleotide changes (or Single Nucleotide Polymorphisms) that alter the amino acid sequence.

His group has been dedicated to making their tools available online as demonstrated through the first internet server for protein structure prediction and sequence analysis, Predictprotein,[2] that was launched in 1992, and has been continuously in service ever since. Rost's work has been published in leading peer reviewed scientific journals including Nature,[9][19][20][21] Science,[22] PLOS Genetics.[23]

ISCB

In 2007 Rost was elected president of the International Society for Computational Biology (ISCB), taking over from Michael Gribskov. Rost served as president until 2014; his successor was Alfonso Valencia.

Conferences

Rost has co-chaired the largest annual meeting in computational biology ISMB, Intelligent Systems for Molecular Biology, in 2007 (Vienna), 2008 (Toronto), 2011 (Vienna), 2012 (Long Beach).[24] He has initiated and been involved in the organization of several series of international conferences outside the usual northern hemisphere, namely ISCB Africa (2010: Bamako, Mali; 2011: Cape Town, South Africa; 2013: Tunis, Tunisia) in cooperation with the African Society for Bioinformatics and Computational Biology, ISCB Latin America (2010: Montevideo, Uruguay; 2012: Santiago de Chile, Chile; 2014: Rio de Janeiro, Brazil), and most recently ISCB Asia (2011: Kuala Lumpur, Malaysia; 2012: Shen Zhen, China).[25]

Rost has also been a co-organizer of the Critical Assessment of protein Structure Prediction (CASP) meetings from 2002-2008 (CASP4-CASP8).

Awards and honors

Rost was awarded the Professorship of the Alexander von Humboldt Foundation in 2009. He was made a Fellow of the ISCB in 2015.[26] In 2016, he was awarded the Outstanding Contribution to ISCB.[25]

References
  1. Rost, Burkhard (1994). Neuronale Netzwerke und evolutionäre Information : verbesserte Vorhersage der Sekundärstruktur von Proteinen (PhD thesis). Heidelberg University. OCLC 311916999.
  2. Rost, B.; Yachdav, G.; Liu, J. (2004). "The PredictProtein server". Nucleic Acids Research. 32 (Web Server issue): W321–W326. doi:10.1093/nar/gkh377. PMC 441515. PMID 15215403.
  3. "Hochdotierte Humboldt-Professur für neuen TUM-Spitzenforscher" [Highly endowed Humboldt Professorship for new top TUM researcher] (in German). 15 October 2008. Retrieved 21 May 2021.
  4. Category:Fellows of the International Society for Computational Biology
  5. Radivojac, P.; Clark, W. T.; Oron, T. R.; Schnoes, A. M.; Wittkop, T.; Sokolov, A.; Graim, K.; Funk, C.; Verspoor, K.; Ben-Hur, A.; Pandey, G.; Yunes, J. M.; Talwalkar, A. S.; Repo, S.; Souza, M. L.; Piovesan, D.; Casadio, R.; Wang, Z.; Cheng, J.; Fang, H.; Gough, J.; Koskinen, P.; Törönen, P.; Nokso-Koivisto, J.; Holm, L.; Cozzetto, D.; Buchan, D. W. A.; Bryson, K.; Jones, D. T.; et al. (2013). "A large-scale evaluation of computational protein function prediction". Nature Methods. 10 (3): 221–227. doi:10.1038/nmeth.2340. PMC 3584181. PMID 23353650.
  6. Burkhard Rost publications indexed by Google Scholar
  7. Rost, B.; Sander, C. (1994). "Combining evolutionary information and neural networks to predict protein secondary structure". Proteins: Structure, Function, and Genetics. 19 (1): 55–72. doi:10.1002/prot.340190108. PMID 8066087. S2CID 15203189.
  8. Rost, B.; Sander, C. (1993). "Prediction of Protein Secondary Structure at Better than 70% Accuracy". Journal of Molecular Biology. 232 (2): 584–599. CiteSeerX 10.1.1.17.1418. doi:10.1006/jmbi.1993.1413. PMID 8345525.
  9. Rost, B.; Sander, C. (1992). "Jury returns on structure prediction". Nature. 360 (6404): 540. Bibcode:1992Natur.360..540R. doi:10.1038/360540b0. PMID 1281284. S2CID 4234785.
  10. "Welcome to the Rostlab! | ROSTLAB.ORG". www.rostlab.org. Retrieved 21 May 2021.
  11. Burkhard Rost at DBLP Bibliography Server
  12. Burkhard Rost publications indexed by Microsoft Academic
  13. Burkhard Rost's publications indexed by the Scopus bibliographic database. (subscription required)
  14. Rost, B. (1999). "Twilight zone of protein sequence alignments". Protein Engineering. 12 (2): 85–94. doi:10.1093/protein/12.2.85. PMID 10195279.
  15. Bateman, A.; Kelso, J.; Mietchen, D.; MacIntyre, G.; Di Domenico, T. S.; Abeel, T.; Logan, D. W.; Radivojac, P.; Rost, B. (2013). "ISCB Computational Biology Wikipedia Competition". PLOS Computational Biology. 9 (9): e1003242. Bibcode:2013PLSCB...9E3242B. doi:10.1371/journal.pcbi.1003242. PMC 3777890. PMID 24068913.
  16. "Welcome to the Rostlab". rostlab.org. Archived from the original on 2014-12-21.
  17. Rost, B. (1996). PHD: Predicting one-dimensional protein structure by profile-based neural networks. Methods in Enzymology. Vol. 266. pp. 525–539. doi:10.1016/s0076-6879(96)66033-9. ISBN 9780121821678. PMID 8743704.
  18. Liu, J.; Rost, B. (2004-07-01). "CHOP: parsing proteins into structural domains". Nucleic Acids Research. 32 (Web Server): W569–W571. doi:10.1093/nar/gkh481. PMC 441619. PMID 15215452.
  19. Chen, Y. H.; Hu, L.; Punta, M.; Bruni, R.; Hillerich, B.; Kloss, B.; Rost, B.; Love, J.; Siegelbaum, S. A.; Hendrickson, W. A. (2010). "Homologue structure of the SLAC1 anion channel for closing stomata in leaves". Nature. 467 (7319): 1074–1080. Bibcode:2010Natur.467.1074C. doi:10.1038/nature09487. PMC 3548404. PMID 20981093.
  20. Cao, Y; Jin, X; Huang, H; Derebe, M. G.; Levin, E. J.; Kabaleeswaran, V; Pan, Y; Punta, M; Love, J; Weng, J; Quick, M; Ye, S; Kloss, B; Bruni, R; Martinez-Hackert, E; Hendrickson, W. A.; Rost, B; Javitch, J. A.; Rajashankar, K. R.; Jiang, Y; Zhou, M (2011). "Crystal structure of a potassium ion transporter, TrkH". Nature. 471 (7338): 336–40. Bibcode:2011Natur.471..336C. doi:10.1038/nature09731. PMC 3077569. PMID 21317882.
  21. Cao, Y.; Jin, X.; Levin, E. J.; Huang, H.; Zong, Y.; Quick, M.; Weng, J.; Pan, Y.; Love, J.; Punta, M.; Rost, B.; Hendrickson, W. A.; Javitch, J. A.; Rajashankar, K. R.; Zhou, M. (2011). "Crystal structure of a phosphorylation-coupled saccharide transporter". Nature. 473 (7345): 50–54. Bibcode:2011Natur.473...50C. doi:10.1038/nature09939. PMC 3201810. PMID 21471968.
  22. Carninci, P; Kasukawa, T; Katayama, S; Gough, J; Frith, M. C.; Maeda, N; Oyama, R; Ravasi, T; Lenhard, B; Wells, C; Kodzius, R; Shimokawa, K; Bajic, V. B.; Brenner, S. E.; Batalov, S; Forrest, A. R.; Zavolan, M; Davis, M. J.; Wilming, L. G.; Aidinis, V; Allen, J. E.; Ambesi-Impiombato, A; Apweiler, R; Aturaliya, R. N.; Bailey, T. L.; Bansal, M; Baxter, L; Beisel, K. W.; Bersano, T; et al. (2005). "The transcriptional landscape of the mammalian genome". Science. 309 (5740): 1559–63. Bibcode:2005Sci...309.1559F. doi:10.1126/science.1112014. PMID 16141072. S2CID 8712839.
  23. Liu, J.; Gough, J.; Rost, B. (2006). "Distinguishing Protein-Coding from Non-Coding RNAs through Support Vector Machines". PLOS Genetics. 2 (4): e29. doi:10.1371/journal.pgen.0020029. PMC 1449884. PMID 16683024.
  24. Linial, M.; Mesirov, J. P.; Morrison Mckay, B. J.; Rost, B. (2008). "ISMB 2008 Toronto". PLOS Computational Biology. 4 (6): e1000094. Bibcode:2008PLSCB...4E0094L. doi:10.1371/journal.pcbi.1000094. PMC 2427177. PMID 18584023.
  25. "2016 Outstanding Contribution to ISCB: Burkhard Rost". www.iscb.org. Retrieved 21 May 2021.
  26. "Meet the ISCB Fellows Class of 2015". International Society for Computational Biology. Archived from the original on 2015-02-20.
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