Etonitazepipne

Etonitazepipne (N-piperidino etonitazene) is a benzimidazole derivative with opioid effects around 100 times more potent than morphine,[1] which has been sold over the internet as a designer drug.[2][3][4][5]

Etonitazepipne
Legal status
Legal status
Identifiers
  • 2-[(4-Ethoxyphenyl)methyl]-5-nitro-1-(2-piperidin-1-ylethyl)benzimidazole
CAS Number
PubChem CID
UNII
Chemical and physical data
FormulaC23H28N4O3
Molar mass408.502 g·mol−1
3D model (JSmol)
  • CCOC1=CC=C(C=C1)CC2=NC3=C(N2CCN4CCCCC4)C=CC(=C3)[N+](=O)[O-]
  • InChI=1S/C23H28N4O3/c1-2-30-20-9-6-18(7-10-20)16-23-24-21-17-19(27(28)29)8-11-22(21)26(23)15-14-25-12-4-3-5-13-25/h6-11,17H,2-5,12-16H2,1H3
  • Key:UMGXRAISFRUVKD-UHFFFAOYSA-N

See also

References
  1. Hunger A, Kebrle J, Rossi A, Hoffmann K (1960). "Benzimidazol-Derivate und verwandte Heterocyclen III. Synthese von 1-Aminoalkyl-2-benzyl-nitro-benzimidazolen". Helvetica Chimica Acta. 43 (4): 1032–1046. doi:10.1002/hlca.19600430412.
  2. "Alert from NDEWS Web Monitoring Team: Increase in discussion of etonitazepipne". National Drug Early Warning System. Weekly Briefing (43). 9 July 2021.
  3. "Warnings Etonitazepipne". Knowdrugs.app. 9 August 2021.
  4. Vandeputte, Marthe M.; Verougstraete, Nick; Walther, Donna; Glatfelter, Grant C.; Malfliet, Jeroen; Baumann, Michael H.; Verstraete, Alain G.; Stove, Christophe P. (April 2022). "First identification, chemical analysis and pharmacological characterization of N-piperidinyl etonitazene (etonitazepipne), a recent addition to the 2-benzylbenzimidazole opioid subclass". Archives of Toxicology. 96 (6): 1865–1880. doi:10.1007/s00204-022-03294-2. hdl:1854/LU-8751259. ISSN 1432-0738. PMID 35449307. S2CID 253718213.
  5. Calello, Diane P.; Aldy, Kim; Jefri, Mohamed; Nguyen, Tuyet-Anh T.; Krotulski, Alex; Logan, Barry; Brent, Jeffrey; Wax, Paul; Walton, Sara; Manini, Alex F. (June 2022). "Identification of a novel opioid, N-piperidinyl etonitazene (etonitazepipne), in patients with suspected opioid overdose". Clinical Toxicology. 60 (9): 1067–1069. doi:10.1080/15563650.2022.2084406. ISSN 1556-3650. PMC 9815205. PMID 35708103.



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