Papaver somniferum

Papaver somniferum, commonly known as the opium poppy[2] or breadseed poppy,[3] is a species of flowering plant in the family Papaveraceae. It is the species of plant from which both opium and poppy seeds are derived and is also a valuable ornamental plant grown in gardens. Its native range was east of the Mediterranean Sea, but now is obscured by ancient introductions and cultivation, being naturalized across much of Europe and Asia.

Papaver somniferum
Scientific classification Edit this classification
Kingdom: Plantae
Clade: Tracheophytes
Clade: Angiosperms
Clade: Eudicots
Order: Ranunculales
Family: Papaveraceae
Genus: Papaver
Species:
P. somniferum
Binomial name
Papaver somniferum

This poppy is grown as an agricultural crop on a large scale, for one of three primary purposes. The first is to produce seeds that are eaten by humans, commonly known as poppy seed. The second is to produce opium for use mainly by the pharmaceutical industry.[4] The third is to produce other alkaloids, mainly thebaine and oripavine, that are processed by pharmaceutical companies into drugs such as hydrocodone and oxycodone.[4] Each of these goals has special breeds that are targeted at one of these businesses, and breeding efforts (including biotechnological ones) are continually underway.[4][5][6] A comparatively small amount of P. somniferum is also produced commercially for ornamental purposes.

Today many varieties have been bred that do not produce a significant quantity of opium.[3][5] The cultivar 'Sujata' produces no latex at all.[6] Breadseed poppy is more accurate as a common name today because all varieties of P. somniferum produce edible seeds. This differentiation has strong implications for legal policy surrounding the growing of this plant.[5]

Description

Papaver somniferum is an annual herb growing to about 100 centimetres (40 inches) tall. The plant is strongly glaucous, giving a greyish-green appearance, and the stem and leaves bear a sparse distribution of coarse hairs. The large leaves are lobed, the upper stem leaves clasping the stem,[7] the lowest leaves with a short petiole.[8]: 40  The flowers are up to 3–10 cm (1–4 in) diameter, normally with four white, mauve or red petals, sometimes with dark markings at the base. The fruit is a hairless, rounded capsule topped with 12–18 radiating stigmatic rays, or fluted cap.[9] All parts of the plant exude white latex when wounded.[7]: 93 [10]: 32 

The weed poppy Papaver rhoeas is a similar species.

  • Plant showing the typical glaucous appearance
    Plant showing the typical glaucous appearance
  • Flower
    Flower
  • Close-up of flower center
    Close-up of flower center
  • Capsule showing latex (opium) exuding from incision
    Capsule showing latex (opium) exuding from incision
  • Close-up of white poppy seeds
    Close-up of white poppy seeds

Metabolism

The alkaloids are organic nitrogenous compounds, derivatives of secondary metabolism, synthesized through the metabolic pathway of benzylisoquinoline.[11] First, the amino acid phenylalanine, through the enzyme phenylalanine hydroxylase, is transformed into tyrosine. Tyrosine can follow two different routes: by tyrosine hydroxylase it can form L-dopamine (L-DOPA), or it can be reduced to form 4-phenylhydroxyacetaldehyde (4-HPAA). Subsequently, L-DOPA reacts with 4-HPAA and, through a series of reactions, forms (S) -norcoclaurine, which carries the benzylisoquinoline skeleton that gives its name to this pathway. The conversion of (S) -norcoclaurin to (S) -reticuline is one of the key points, since from (S) -reticuline morphine can be formed through the morphinan route, noscapine through the path of the noscapina or berberina.[11]

Genome

The poppy genome contains 51,213 genes encoding proteins distributed 81.6% in 11 individual chromosomes and 18.4% remaining in unplaced scaffolds.[11] In addition, 70.9% of the genome is made up of repetitive elements, of which the most represented are the long terminal repeat retrotransposons. This enrichment of genes is related to the maintenance of homeostasis and a positive regulation of transcription.[11]

The analysis of synergy of the opium poppy reveals traces of segmental duplications 110 million years ago (MYA), before the divergence between Papaveraceae and Ranunculaceae, and an event of duplication of the complete genome makes 7.8 MYA.

The genes are possibly grouped as follows:[11]

  • The genes responsible for the conversion of (S) -reticuline to noscapine are found on chromosome 11.
  • The genes responsible for the conversion of (S) -reticuline to thebaine are found on chromosome 11.
  • The genes responsible for the conversion of thebaine are found in chromosome 1, chromosome 2, chromosome 7, and perhaps others.

Taxonomy

Papaver somniferum was formally described by the Swedish botanist Carl Linnaeus in his seminal publication Species Plantarum in 1753 on page 508.[12][13]

Varieties and cultivars

P. somniferum has had a very long tradition of use, starting in the Neolithic. This long period of time allowed the development of a broad range of different forms. In total there are 52 botanical varieties.[14] Breeding of P. somniferum faces a challenge caused by the contradictory breeding goals for this species.[14] On one hand a very high content of alkaloids is requested for medical uses. The global demand for the alkaloids and the pharmaceutical derivatives has increased in the past years. Therefore, there is a need for the development of varieties with a high opium yield.[15] On the other hand, the food industry demands as low alkaloid contents as possible.[14]

There is one accepted subspecies, P. somniferum subsp. setigerum (DC.) Arcang.[12] There are also many varieties and cultivars. Colors of the flowers vary widely, as do other physical characteristics, such as number and shape of petals , number of flowers and fruits, number of seeds, color of seeds, and production of opium. Papaver somniferum var. paeoniflorum is a variety with flowers that are highly double, and are grown in many colors. P. somniferum var. laciniatum is a variety with flowers that are highly double and deeply lobed. The variety Sujata produces no latex and no commercial utility for opioid production.

Distribution and habitat

The native range of opium poppy is probably the Eastern Mediterranean, but extensive cultivation and introduction of the species throughout Europe since ancient times have obscured its origin. It has escaped from cultivation, or has been introduced and become naturalized extensively in all regions of the British Isles, particularly in the south and east[16] and in almost all other countries of the world with suitable, temperate climates.[17]

Ecology

Diseases

P. somniferum is susceptible to several fungal, insect and virus infections including seed borne diseases such as downy mildew and root rot. The use of pesticides in combination to cultural methods have been considered as major control measures for various poppy diseases.[18]

The fungal pathogen Peronospora arborescens, the causal agent of downy mildew, occurs preferentially during wet and humid conditions.[19] This oomycete penetrates the roots through oospores and infects the leaves as conidia in a secondary infection.[20] The fungus causes hypertrophy and curvature of the stem and flower stalks.[21] The symptoms are chlorosis and curling of the affected tissues with necrotic spots.[22] The leaf under-surface is covered with a downy mildew coating containing conidiospores that spread the infection further leading to plant damage and death.[23] Another downy mildew species, Peronospora somniferi, produces systemic infections leading to stunting and deformation of poppy plants.[24] Downy mildew can be controlled preventively at the initial stage of seed development through several fungicide applications.[19]

Leaf blight caused by the fungus Helminthosporium papaveris is one of the most destructive poppy diseases worldwide. The seed-borne fungus causes root rot in young plants and stunted stems in plants at a higher development stage, where leaf spots appear on the leaves and is being transmitted to capsules and seeds.[23] Early sowing of seeds and deep plowing of poppy residues can reduce fungal inoculum during the plant growing season in the following year on neighboring poppy stocks, respectively.[19]

Mosaic diseases in p. somniferum are caused by rattle virus and the Carlavirus.[18] In 2006, a novel virus tentatively called "opium poppy mosaic virus" (OPMV) from the genus Umbravirus was isolated from p. somniferum containing leaf mosaic and mottling symptoms, in New Zealand.[25]

Pests

There are only a few pests that can do harm to P. somniferum.[19]

Flea beetles perforate the leaves of young plants and aphids suck on the sap of the flower buds.[19] The poppy root weevil (Stenocarus ruficornis) is another significant pest. The insect lives in the soil and migrates in spring to the poppy fields after crop emergence. Adults damage the leaves of small plants by eating them. Female lay their eggs into the tissue of lower leaves. Insect larvae hatch and burrow into the soil to complete their life cycle on the poppy roots as adults.[26]

Cultivation

In the growth development of P. somniferum, six stages can be distinguished. The growth development starts with the growth of the seedlings. In a second step the rosette-type leaves and stalks are formed. After that budding (hook stage) takes place as a third step. The hook stage is followed by flowering. Subsequently, technical maturity is reached, which means that the plant is ready for cutting. The last step is biological maturity; dry seeds are ripened. The photoperiod seems to be the main determinant of flower development of P. somniferum.[27]

P. somniferum shows a very slow development in the beginning of its vegetation period. Due to this fact the competition of weeds is very high in early stages. It is very important to control weeds effectively in the first 50 days after sowing.[28] Additionally Papaver somniferum is rather susceptible to herbicides. The pre-emergence application of the herbicide chlortoluron has been shown to be effective in reducing weed levels.[28] However, in the last decade the weed management of Papaver somniferum has shifted from pre-emergence treatments to post-emergence treatments.[29] Especially the application of the two herbicides mesotrione and tembotrione has become very popular. The combined application of those two herbicides has been shown to be recommendable for effective weed management in Papaver somniferum.[29] Sowing time (autumn or spring), preceding crop and soil texture are important variables influencing the weed species composition. A highly abundant weed species in Papaver somniferum fields was shown to be Papaver rhoeas.[29][30] Papaver somniferum and Papaver rhoeas belong to the same plant family, which impedes the chemical control of this weed species.[30] Therefore, weed management represents a big challenge and requires technological knowledge from the farmer.[30] In order to increase the efficiency of weed control not only chemical weed control should be applied but also mechanical weed control.[30]

For P. somniferum, a growth density of 70 to 80 plants per square meter is recommended.[31]

Ornamental

Live plants and seeds of the opium poppy are widely sold by seed companies and nurseries in most of the western world, including the United States. Poppies are sought after by gardeners for the vivid coloration of the blooms, the hardiness and reliability of the poppy plants, the exotic chocolate-vegetal fragrance note of some cultivars, and the ease of growing the plants from purchased flats of seedlings or by direct sowing of the seed. Poppy seed pods are also sold for dried flower arrangements.

Though "opium poppy and poppy straw" are listed in Schedule II of the United States' Controlled Substances Act, P. somniferum can be grown legally in the United States as a seed crop or ornamental flower.[32] During the summer, opium poppies can be seen flowering in gardens throughout North America and Europe, and displays are found in many private plantings, as well as in public botanical and museum gardens such as United States Botanical Garden, Missouri Botanical Garden, and North Carolina Botanical Garden.

Many countries grow the plants, and some rely heavily on the commercial production of the drug as a major source of income. As an additional source of profit, the seeds of the same plants are sold for use in foods, so the cultivation of the plant is a significant source of income. This international trade in seeds of P. somniferum was addressed by a UN resolution "to fight the international trade in illicit opium poppy seeds" on 28 July 1998.

  • Red opium poppy flower
    Red opium poppy flower
  • Czech blue poppy flower
    Czech blue poppy flower
  • Czech blue poppy seeds
    Czech blue poppy seeds

Production
Poppy seed production – 2018
Country (tonnes)
 Turkey26,991
 Czech Republic13,666
 Spain12,360
World76,240
Source: FAOSTAT of the United Nations[33]

Food

In 2018, world production of poppy seeds for consumption was 76,240 tonnes, led by Turkey with 35% of the world total (table). Poppy seed production and trade are susceptible to fluctuations mainly due to unstable yields. The performance of most genotypes of "Papaver somniferum" is very susceptible to environmental changes[34] This behaviour led to a stagnation of the poppy seed market value between 2008–2009 as a consequence of high stock levels, bad weather and poor quality.[35] The world leading importer of poppy seed is India (16 000 tonnes), followed by Russia, Poland and Germany.[36]

Poppy seed oil remains a niche product due to the lower yield compared to conventional oil crops.[37]

Medicine

Australia (Tasmania), Turkey and India are the major producers of poppy for medicinal purposes and poppy-based drugs, such as morphine or codeine.[38][15] The New York Times reported, in 2014, that Tasmania was the largest producer of the poppy cultivars used for thebaine (85% of the world's supply) and oripavine (100% of the world's supply) production. Tasmania also had 25% of the world's opium and codeine production.[4]

Restrictions
Opium poppy fields near Metheringham, Lincolnshire, England

In most of Central Europe, poppy seed is commonly used for traditional pastries and cakes, and it is legal to grow poppies throughout the region, although Germany requires a licence.[39]

Since January 1999 in the Czech Republic, according to the 167/1998 Sb. Addictive Substances Act, poppies growing in fields larger than 100 square metres (120 sq yd) is obliged for reporting to the local Custom Office.[40][41] Extraction of opium from the plants is prohibited by law (§ 15 letter d/ of the act). It is also prohibited to grow varieties with more than 0.8% of morphine in dry matter of their capsules, excluding research and experimental purposes (§24/1b/ of the act). The name Czech blue poppy refers to blue poppy seeds used for food.

The United Kingdom does not require a licence for opium poppy cultivation, but does for extracting opium for medicinal products.[42]

In the United States, opium poppies and poppy straw are prohibited.[43] As the opium poppy is legal for culinary or esthetic reasons, poppies were once grown as a cash crop by farmers in California. The law of poppy cultivation in the United States is somewhat ambiguous.[44] The reason for the ambiguity is that the Opium Poppy Control Act of 1942 (now repealed)[45][46] stated that any opium poppies should be declared illegal, even if the farmers were issued a state permit. § 3 of the Opium Poppy Control Act stated:

It shall be unlawful for any person who is not the holder of a license authorizing him to produce the opium poppy, duly issued to him by the Secretary of the Treasury in accordance with the provisions of this Act, to produce the opium poppy, or to permit the production of the opium poppy in or upon any place owned, occupied, used, or controlled by him.

This led to the Poppy Rebellion, and to the Narcotics Bureau arresting anyone planting opium poppies and forcing the destruction of poppy fields of anyone who defied the prohibition of poppy cultivation.[47][48] Though the press of those days favored the Federal Bureau of Narcotics, the state of California supported the farmers who grew opium poppies for their seeds for uses in foods such as poppy seed muffins. Today, this area of law has remained vague and remains somewhat controversial in the United States.[49] The Opium Poppy Control Act of 1942 was repealed on 27 October 1970.[50][51]

Under the Federal Controlled Substances Act opium poppy and poppy straw are listed as Schedule II drugs under ACSN 9630. Most (all?) states also use this classification under the uniform penal code. Possession of a Schedule II drug is a federal and state felony.

Canada forbids possessing, seeking or obtaining the opium poppy (Papaver somniferum), its preparations, derivatives, alkaloids and salts, although an exception is made for poppy seed.[52]

In some parts of Australia, P. somniferum is illegal to cultivate, but in Tasmania, some 50% of the world supply is cultivated.[53]

In New Zealand, it is legal to cultivate the opium poppy as long as it is not used to produce controlled drugs.[54]

In United Arab Emirates the cultivation of the opium poppy is illegal, as is possession of poppy seed. At least one man has been imprisoned for possessing poppy seed obtained from a bread roll.[55]

Burma bans cultivation in certain provinces. In northern Burma bans have ended a century-old tradition of growing the opium poppy. Between 20,000 and 30,000 former poppy farmers left the Kokang region as a result of the ban in 2002.[56] People from the Wa region, where the ban was implemented in 2005, fled to areas where growing opium is still possible.

In South Korea, the cultivation of the opium poppy is strictly prohibited.[57]

Uses

History
See also: Opium

Use of the opium poppy predates written history. The making and use of opium was known to the ancient Minoans.[58] Its sap was later named opion by the ancient Greeks. The English name is based on the Latin adaptation of the Greek form. Evidence of the early domestication of opium poppy has been discovered through small botanical remains found in regions of the Mediterranean and west of the Rhine River, predating circa 5000 BC.[59] These samples found in various Neolithic sites show the incredibly early cultivation and natural spread of the plant throughout western Europe.

Opium was used for treating asthma, stomach illnesses, and bad eyesight.

Opium became a major colonial commodity, moving legally and illegally through trade networks on the Indian subcontinent, Colonial America, Qing China and others.[60] Members of the East India Company saw the opium trade as an investment opportunity beginning in 1683.[61] In 1773, the Governor of Bengal established a monopoly on the production of Bengal opium, on behalf of the East India Company administration. The cultivation and manufacture of Indian opium was further centralized and controlled through a series of acts issued between 1797 and 1949.[61][62] East India Company merchants balanced an economic deficit from the importation of Chinese tea by selling Indian opium which was smuggled into China in defiance of Qing government bans. This trade led to the First and Second Opium Wars.[63][62][60][64]

Many modern writers, particularly in the 19th century, have written on the opium poppy and its effects, notably Thomas de Quincey in Confessions of an English Opium Eater.

The French Romantic composer Hector Berlioz used opium for inspiration, subsequently producing his Symphonie Fantastique. In this work, a young artist overdoses on opium and experiences a series of visions of his unrequited love.

In the US, the Drug Enforcement Administration raided Thomas Jefferson's Monticello estate in 1987. It removed the poppy plants that had been planted continually there since Jefferson was alive and using opium from them. Employees of the foundation also destroyed gift shop items like shirts depicting the poppy and packets of the heirloom seed.[65]

Poppy seeds and oil
Main article: Poppy seed
Dried blue, grey and white poppy seeds used for pastries in Germany
Polish makowiec, a nut roll filled with poppy seed paste

Poppy seeds from Papaver somniferum are an important food item and the source of poppy seed oil, an edible oil that has many uses. The seeds contain very low levels of opiates and the oil extracted from them contains even less.[66] Both the oil and the seed residue also have commercial uses.

The poppy press cake as a residue of the oil pressing can be used as fodder for different animals as e.g., poultry and fancy fowls. Especially in the time of the molt of the birds, the cake is nutritive and fits to their special needs. Next to the animal fodder, poppy offers other by-products. For example, the stem of the plant can be used for energy briquettes and pellets to heat.[19]

Poppy seeds are used as a food in many cultures. They may be used whole by bakers to decorate their products or milled and mixed with sugar as a sweet filling. They have a creamy and nut-like flavor, and when used with ground coconut, the seeds provide a unique and flavour-rich curry base. They can be dry roasted and ground to be used in wet curry (curry paste) or dry curry.[67]

When the European Union attempted to ban the cultivation of Papaver somniferum by private individuals on a small scale (such as personal gardens), citizens in EU countries where poppy seed is eaten heavily, such as countries in the Central-Eastern region, strongly resisted the plan, causing the EU to change course. Singapore, UAE, and Saudi Arabia are among nations that ban even having poppy seeds, not just growing the plants for them.[68] The UAE has a long prison sentence for anyone possessing poppy seeds.[69]

Opiates
Main article: Opium
Dried poppy seed pods and stems (plate), and seeds (bowl)

The opium poppy, as its name indicates, is the principal source of opium, the dried latex produced by the seed pods. Opium contains a class of naturally occurring alkaloids known as opiates, that include morphine, codeine, thebaine, oripavine, papaverine and noscapine.[70][71] The specific epithet somniferum means "sleep-bringing", referring to the sedative properties of some of these opiates.[72]

The opiate drugs are extracted from opium. The latex oozes from incisions made on the green seed pods and is collected once dry. Tincture of opium or laudanum, consisting of opium dissolved in alcohol or a mixture of alcohol and water, is one of many unapproved drugs regulated by the U.S. Food and Drug Administration (FDA). Its marketing and distribution persists because its historical use preceded the Federal Food, Drug & Cosmetic Act of 1938.[73] Tincture of opium B.P., containing 1% w/v of anhydrous morphine, also remains in the British Pharmacopoeia,[74] listed as a Class A substance under the Misuse of Drugs Act 1971.

Morphine is the predominant alkaloid found in the cultivated varieties of opium poppy that are used for opium production.[75] Other varieties produce minimal opium or none at all, such as the latex-free Sujata type. Non-opium cultivars that are planted for drug production feature a high level of thebaine or oripavine. Those are refined into drugs like oxycodone. Raw opium contains about 8–14% morphine by dry weight, or more in high-yield cultivars.[76] It may be used directly or chemically modified to produce synthetic opioids such as heroin.

Culture

Opium poppies (flower and fruit) appear on the coat of arms of the Royal College of Anaesthetists.

References
  1. Linnaeus, Carl von (1753). Species Plantarum. Vol. 1. Laurentius Salvius. p. 508.
  2. BSBI List 2007 (xls). Botanical Society of Britain and Ireland. Archived from the original (xls) on 26 June 2015. Retrieved 17 October 2014.
  3. "Breadseed or opium poppy, Papaver somniferum" (PDF). University of Wisconsin Extension, Master Gardener Program. Retrieved 21 November 2020.
  4. Bradsher, Keith (19 July 2014). "Shake-Up on Opium Island". The New York Times. Retrieved 8 January 2018.
  5. Gaevskii, A.V. (1999). "On the intraspecies classification of opium poppy (Papaver somniferum L.)". Khimiko-Farmatsevticheskii Zhurnal. 33 (3): 32–36. doi:10.1007/BF02508453. S2CID 9716321.
  6. Chaturvedi, Nidarshana (2014). "Latex-less opium poppy: cause for less latex and reduced peduncle strength)" (PDF). Physiologia Plantarum. 150 (3): 436–445. doi:10.1111/ppl.12086. PMID 24033330. Retrieved 7 January 2018.
  7. Stace, C. A. (2019). New Flora of the British Isles (Fourth ed.). Middlewood Green, Suffolk, U.K.: C & M Floristics. ISBN 978-1-5272-2630-2.
  8. Clapham, A.R.; Tutin, T.G.; Warburg, E.F. (1981). Excursion flora of the British Isles (3 ed.). Cambridge, U.K.: Cambridge University Press. ISBN 978-0521232906.
  9. Reader's Digest Field Guide to the Wild Flowers of Britain. Reader's Digest. 1981. p. 32. ISBN 9780276002175.
  10. Blamey, M.; Fitter, R.; Fitter, A (2003). Wild flowers of Britain and Ireland: The Complete Guide to the British and Irish Flora. London: A & C Black. ISBN 978-1408179505.
  11. Ye, Kai; Graham, Ian A.; Bowser, Tim A.; Lu, Ying; Teodor, Roxana; He, Zhesi; Ning, Zemin; Li, Yi; Yang, Xiaofei (19 October 2018). "The opium poppy genome and morphinan production" (PDF). Science. 362 (6412): 343–347. Bibcode:2018Sci...362..343G. doi:10.1126/science.aat4096. ISSN 0036-8075. PMID 30166436. S2CID 52137369.
  12. "Papaver somniferum L." Plants of the World Online. Royal Botanic Gardens, Kew. 16 May 2023. Retrieved 16 May 2023.
  13. Papaveraceae Papaver somniferum L. Vol. 1. ipni.org. Retrieved 1 November 2017.
  14. Dittbrenner, A. (2009). "Variability of alkaloid content in Papaver somniferum L ". Journal of Applied Botany and Food Quality. 107: 103–107.
  15. Yadav, Hemant K.; Shukla, S.; Singh, S. P. (16 August 2006). "Genetic Variability and Interrelationship Among Opium and its Alkaloids in Opium Poppy (Papaver Somniferum L.)". Euphytica. 150 (1–2): 207–214. doi:10.1007/s10681-006-9111-x. ISSN 0014-2336. S2CID 25242061.
  16. "BSBI Distribution Maps, Papaver somniferum". London, U.K.: Botanical Society of Britain and Ireland. 22 April 2016.
  17. "Papaver somniferum L." Copenhagen, Denmark: Global Biodiversity Information Facility, GBIF.org.
  18. Singh, Akanksha; Gupta, Rupali; Saikia, Shilpi K.; Pant, Aakanksha; Pandey, Rakesh (December 2016). "Diseases of medicinal and aromatic plants, their biological impact and management". Plant Genetic Resources. 14 (4): 370–383. doi:10.1017/S1479262116000307. ISSN 1479-2621. S2CID 88963681.
  19. Wilfried., Ahrens (2000). Mohn : Sorten, Anbau, Rezepte. Sneyd, Jan. Stuttgart (Hohenheim): Ulmer. ISBN 978-3800131129. OCLC 76179514.
  20. Voglmayr, Hermann; Montes-Borrego, Miguel; Landa, Blanca B. (7 May 2014). "Disentangling Peronospora on Papaver: Phylogenetics, Taxonomy, Nomenclature and Host Range of Downy Mildew of Opium Poppy (Papaver somniferum) and Related Species". PLOS ONE. 9 (5): e96838. Bibcode:2014PLoSO...996838V. doi:10.1371/journal.pone.0096838. ISSN 1932-6203. PMC 4013089. PMID 24806292.
  21. Bajpai, S.; Gupta, M. M.; Kumar, S. (September 1999). "Identification of Indian Landraces of Opium Poppy Papaver somniferum Resistant to Damping-off and Downy Mildew Fungal Diseases". Journal of Phytopathology. 147 (9): 535–538. doi:10.1046/j.1439-0434.1999.147009535.x. ISSN 0931-1785.
  22. Barnawal, D.; Pandey, S.S.; Bharti, N.; Pandey, A.; Ray, T.; Singh, S.; Chanotiya, C.S.; Kalra, A. (3 April 2017). "ACC deaminase-containing plant growth-promoting rhizobacteria protect Papaver somniferum from downy mildew". Journal of Applied Microbiology. 122 (5): 1286–1298. doi:10.1111/jam.13417. ISSN 1364-5072. PMID 28186676. S2CID 33398558.
  23. D., Kapoor, L. (1995). Opium poppy : botany, chemistry, and pharmacology. New York: Food Products Press. ISBN 978-1560249238. OCLC 30544395.{{cite book}}: CS1 maint: multiple names: authors list (link)
  24. Thangavel, T.; Wilson, C. R.; Jones, S.; Scott, J. B.; Voglmayr, H. (February 2017). "First Report of Systemic Downy Mildew of Opium Poppy Caused by Peronospora somniferi in Australia". Plant Disease. 101 (2): 392. doi:10.1094/pdis-06-16-0796-pdn. ISSN 0191-2917.
  25. Tang, Joe; Lebas, Bénédicte; Liefting, Lia; Veerakone, Stella; Wei, Ting; Ward, Lisa (29 October 2015). "Opium poppy mosaic virus, a new umbravirus isolated from Papaver somniferum in New Zealand". Archives of Virology. 161 (1): 197–201. doi:10.1007/s00705-015-2651-4. ISSN 0304-8608. PMID 26514844. S2CID 16114366.
  26. Bečka, D.; Cihlář, P.; Vlažný, P.; Pazderů, K.; Vašák, J. (3 October 2014). "Poppy root weevils (Stenocarus ruficornis, Stephens 1831) control in opium poppy (Papaver somniferum L.)". Plant, Soil and Environment. 60 (10): 470–474. doi:10.17221/417/2014-pse. ISSN 1214-1178.
  27. Mahdavi-Damghani, Abdolmajid; Kamkar, Behnam; Al-Ahmadi, Majid Jami; Testi, Luca; Muñoz-Ledesma, Francisco J.; Villalobos, Francisco J. (October 2010). "Water stress effects on growth, development and yield of opium poppy (Papaver somniferum L.)". Agricultural Water Management. 97 (10): 1582–1590. doi:10.1016/j.agwat.2010.05.011. hdl:10261/94915. ISSN 0378-3774.
  28. Gaur, B. L.; Gupta, P. C.; Sharma, D. D. (January 1986). "Weed management in opium poppy Papaver somniferumL". Tropical Pest Management. 32 (4): 267–268. doi:10.1080/09670878609371076. ISSN 0143-6147.
  29. Pinke, Gyula; Tóth, Kálmán; Kovács, Attila J.; Milics, Gábor; Varga, Zoltán; Blazsek, Katinka; Gál, Katalin E.; Botta-Dukát, Zoltán (3 July 2014). "Use of mesotrione and tembotrione herbicides for post-emergence weed control in alkaloid poppy (Papaver somniferum)". International Journal of Pest Management. 60 (3): 187–195. doi:10.1080/09670874.2014.953622. ISSN 0967-0874. S2CID 83721260.
  30. PINKE, G; PÁL, R W; TÓTH, K; KARÁCSONY, P; CZÚCZ, B; BOTTA-DUKÁT, Z (16 September 2011). "Weed vegetation of poppy (Papaver somniferum) fields in Hungary: effects of management and environmental factors on species composition". Weed Research. 51 (6): 621–630. doi:10.1111/j.1365-3180.2011.00885.x. ISSN 0043-1737.
  31. "An overview of the Tasmanian poppy industry". Grains Research and Development Corporation. Retrieved 19 January 2020.
  32. "Culinary Poppy Cultivation". WSU Mount Vernon NWREC. Washington State University. Archived from the original on 21 April 2021. Retrieved 14 May 2021.
  33. "Poppy seed production in 2018, Crops/Regions/World list/Production Quantity (pick lists)". UN Food and Agriculture Organization, Corporate Statistical Database (FAOSTAT). 2019. Archived from the original on 22 November 2016. Retrieved 28 November 2020.
  34. Yadav, H.; Shukla, S.; Singh, S. (2007). "Assessment of genotype × environment interactions for yield and morphine content in opium poppy (Papaver somniferumL.)". Acta Agronomica Hungarica. 55 (3): 331–338. doi:10.1556/AAgr.55.2007.3.9.
  35. Procházka, Petr; Smutka, Lubos (30 June 2012). "Czech Republic as an Important Producer of Poppy Seed". AGRIS On-Line Papers in Economics and Informatics. 4 (2): 35–47. Retrieved 15 November 2018.
  36. Sergeeva, Anna. "Global Poppy Seed Market – The Czech Republic Is the Key Producing Country". Index Box. Retrieved 15 November 2018.
  37. Frick, Claudia; Hebeisen, Thomas (2005). "Mohn als alternative Ölpflanze". AGRARForschung. 12 (1): 4–9.
  38. Dicker, Jason. "The Poppy Industry in Tasmania". University of Tasmania. Archived from the original on 11 December 2011. Retrieved 2 September 2009.
  39. Ursula Heinzelmann (2008) Food Culture in Germany p. 48
  40. 167/1998 Sb. Zákon o návykových látkách a o změně některých dalších zákonů, Czech Republic, effective since 1 January 1999; § 29 effective since 1 January 1999; § 29
  41. Ohlašovací povinnost pěstitelů máku a konopí podle par. 29 zákona č. 167/1999 Sb., o návykových látkách, Celní správa (Custom Service of the Czech Republic), 19. 6. 2014
  42. Phillip, Rhodri, & Barry Wigmore (14 July 2007). "The painkilling fields: England's opium poppies that tackle the NHS morphine crisis". Evening Standard. Archived from the original on 5 May 2013. Retrieved 2 September 2009.{{cite web}}: CS1 maint: multiple names: authors list (link)
  43. "Authorized Sources of Narcotic Raw Materials, 21 CFR Part 1312; Docket No. DEA-282F, RIN 1117-AB03". Drug Enforcement Administration, US Department of Justice. 2008. Archived from the original on 3 November 2022. Retrieved 13 September 2017.
  44. "Bulletin on Narcotics – 1950 Issue 3 – 002". UNODC. Retrieved 30 December 2011.
  45. "Controlled Substances Import and Export Act". US Food and Drug Administration. Retrieved 30 December 2011.
  46. "21 U.S.C. § 188 : US Code – Section 188 TO 188N: Repealed. Pub. L. 91-513, title III, Sec. 1101(a)(7), Oct. 27, 1970, 84 Stat. 1292". Codes.lp.findlaw.com. Retrieved 30 December 2011.
  47. Harry J. Anslinger (1959). "The traffic in narcotic drugs: The implementation of treaty obligations in regulating the traffic in narcotic drugs" (PDF). The American University Law Review. 8: 112–116. Archived from the original (PDF) on 1 April 2012. Retrieved 31 October 2011.
  48. Young, Richard (September 1952). "The development of international law". American Bar Association Journal. 38: 778–80.
  49. Richter, Skip. "Poppin' Up Poppies". Texas Gardener. Archived from the original on 4 January 2019. Retrieved 20 May 2021.
  50. "United States Code: Title 21,188 to 188n. Repealed. Pub. L. 91–513, title III, 1101(a)(7), Oct. 27, 1970, 84 Stat. 1292 | LII / Legal Information Institute". Law.cornell.edu. Retrieved 30 December 2011.
  51. "21 USC Chapter 6 – Narcotic Drugs 01/03/2007". Joffelaw.com. Archived from the original on 6 March 2014. Retrieved 30 December 2011.
  52. "Controlled Drugs and Substances Act 1996". Justice Laws Website, Government of Canada. 4 April 2018. Retrieved 20 June 2018.
  53. "Poppy Regulation Act". Department of Primary Industry and Resources, Northern Territory Government, Australia. 2016.
  54. Section 9(4) of the Misuse of Drugs Act states, "It shall be a defense to a charge under subsection (1) [Cultivation of prohibited plants] if the person charged proves that the prohibited plant to which the charge relates was of the species Papaver somniferum, and that it was not intended to be a source of any controlled drug or that it was not being developed as a strain from which a controlled drug could be produced.""New Zealand Legislation: Misuse of Drugs Act 1975". Retrieved 7 July 2012.
  55. McGrath, Ginny (8 February 2008). "Travellers who 'smuggle' poppy seeds face Dubai jail". The Times. UK. Archived from the original on 10 October 2011. Retrieved 2 September 2009.
  56. page 4 of the Drug Policy Briefing nr. 29 by the Transnational Institute
  57. 양귀비·대마 재배 땐 ‘큰일’…관상용 한포기도 절대 안돼
  58. Askitopoulou, Helen; Ramoutsaki, Ioanna A; Konsolaki, Eleni (2002). "Archaeological evidence on the use of opium in the Minoan world". International Congress Series. 1242: 23–29. doi:10.1016/S0531-5131(02)00769-0.
  59. Salavert, Aurélie; Zazzo, Antoine; Martin, Lucie; Antolín, Ferran; Gauthier, Caroline; Thil, François; Tombret, Olivier; Bouby, Laurent; Manen, Claire; Mineo, Mario; Mueller-Bieniek, Aldona (20 November 2020). "Direct dating reveals the early history of opium poppy in western Europe". Scientific Reports. 10 (1): 20263. Bibcode:2020NatSR..1020263S. doi:10.1038/s41598-020-76924-3. ISSN 2045-2322. PMC 7679390. PMID 33219318.
  60. Farooqui A (December 2016). "The Global Career of Indian Opium and Local Destinies" (PDF). Almanack (14): 52–73. doi:10.1590/2236-463320161404. Retrieved 5 September 2018.
  61. Asthana SN (1954). "The Cultivation of the Opium Poppy in India". Bulletin on Narcotics (3). Retrieved 5 September 2018.
  62. Deming S (2011). "The Economic Importance of Indian Opium and Trade with China on Britain's Economy, 1843–1890". Economic Working Papers. 25 (Spring). Archived from the original (PDF) on 12 November 2020. Retrieved 5 September 2018.
  63. Rinde M (2018). "Opioids' Devastating Return". Distillations. 4 (2): 12–23. Retrieved 23 August 2018.
  64. Mills JH (2016). Review of 'Opium and Empire in Southeast Asia: Regulating Consumption in British Burma'. doi:10.14296/RiH/2014/2010. ISBN 9780230296466. Retrieved 5 September 2018. {{cite book}}: |journal= ignored (help)
  65. "How the DEA Scrubbed Thomas Jefferson's Monticello Poppy Garden from Public Memory". AlterNet. 2 March 2010. Archived from the original on 4 December 2018. Retrieved 7 January 2018.
  66. "Papaver somniferum". www.hort.purdue.edu.
  67. "Mahanandi " Gasagasalu ~ Bendakaaya". Nandyala.org. Archived from the original on 3 November 2022. Retrieved 30 December 2011.
  68. "5 Recent Food Bans from Around the World". The Times of India. Retrieved 8 January 2018.
  69. "Travel Warning – Khas Khas (Poppy Seed) Imprisonment in UAE". Brett M.Christensen. Archived from the original on 19 June 2017. Retrieved 8 January 2018.
  70. Singh, A., I. M. Menendez-Perdomo, et al. (2019). "Benzylisoquinoline alkaloid biosynthesis in opium poppy: an update." Phytochem Rev 18(6): 1457-1482
  71. Menéndez-Perdomo I.M., Hagel J.M. and Facchini P.J. (2021). "Benzylisoquinoline alkaloid analysis using high-resolution Orbitrap LC-MSn." J Mass Spectrom 56 (2): e4683
  72. Bronwen Jean Bryant and Kathleen Mary Knights Pharmacology for Health Professionals, p. 290, at Google Books
  73. "Unapproved Drugs, What's the Big Deal?" (PDF). International Journal of Pharmaceutical Compounding, Winter 2006. Archived from the original (PDF) on 5 July 2010. Retrieved 3 January 2009.
  74. The Extra Pharmacopeia Martindale. Vol. 1, 24th edition. London: The Pharmaceutical Press, 1958, page 924.
  75. "International Narcotics Control Bureau, Technical Reports, 2008, Part IV, Statistical information on narcotic drugs" (PDF). Archived from the original (PDF) on 1 March 2012. Retrieved 30 December 2011.
  76. Kapoor L (1995). Opium Poppy: Botany, Chemistry, and pharmacology. United States: CRC Press. p. 164. ISBN 978-1-56024-923-8.

Further reading
  • Rätsch, Christian "The Encyclopedia of Psychoactive Plants, Enthnopharmacology and Its Applications" 1998/2005, Rochester, Vermont, Park Street Press, ISBN 978-0-89281-978-2
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